Biopharmaceutics & Drug Dispositionpublishes original review articles, short communications, and reports in biopharmaceutics, drug disposition, pharmacokinetics and pharmacodynamics, especially those that have a direct relation to the drug discovery/development and the therapeutic use of drugs. These includes:- animal and human pharmacological studies that focus on therapeutic response. pharmacodynamics, and toxicity related to plasma and tissue concentrations of drugs and their metabolites,- in vitro and in vivo drug absorption, distribution, metabolism, transport, and excretion studies that facilitate investigations related to the use of drugs in man- studies on membrane transport and enzymes, including their regulation and the impact of pharmacogenomics on drug absorption and disposition,- simulation and modeling in drug discovery and development- theoretical treatises- includes themed issues and reviewsand exclude manuscripts on- bioavailability studies reporting only on simple PK parameters such as Cmax, tmax and t1/2 without mechanistic interpretation- analytical methods
生物药剂学与药物处置发表生物药剂学、药物处置、药代动力学和药效学方面的原创综述文章、短通讯和报告，特别是与药物发现/开发和药物治疗使用直接相关的文章。这些研究包括：-关注治疗反应的动物和人体药理学研究。药效学和与药物及其代谢物的血浆和组织浓度相关的毒性，-体外和体内药物吸收、分布、代谢、转运和排泄研究，其促进与药物在人体中的使用相关的研究-对膜转运和酶的研究，包括它们的调节和药物基因组学对药物吸收和处置的影响，-药物发现和开发中的模拟和建模-理论论文-包括主题问题和综述，但不包括手稿-仅报告简单PK参数（如Cmax、tmax和t1/2）而无机制解释的生物利用度研究-分析方法
TGF‐β1 elevates P‐gp and BCRP in hepatocellular carcinoma through HOTAIR/miR‐145 axis
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2172
Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator‐activated receptor‐alpha modulator, in rats and monkeys
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2165
Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2171
In Vitro and In Vivo Methods to Assess Pharmacokinetic Drug-Drug Interactions in Drug Discovery and Development.
来源期刊：Biopharmaceutics & drug dispositionDOI：10.1002/bdd.2212
Interaction of platinum agents, cisplatin, carboplatin and oxaliplatin against albumin in vivo rats and in vitro study using inductively coupled plasma‐mass spectrometory
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2197
Identification of specific UGT1A9‐mediated glucuronidation of licoricidin in human liver microsomes
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2169
Screening of ten cytochrome P450 enzyme activities with 12 probe substrates in human liver microsomes using cocktail incubation and liquid chromatography–tandem mass spectrometry
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2174
Use of generally recognized as safe or dietary compounds to inhibit buprenorphine metabolism: potential to improve buprenorphine oral bioavailability
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2166
Hydrogel increases diclofenac skin permeation and absorption
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2194
Effect of endogenous multidrug resistance 1 and P‐glycoprotein expression on anticancer drug resistance in colon cancer cell lines
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2167
A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2173
Application of data mining approach to identify drug subclasses based on solubility and permeability
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2170
Minimal impact of hepatic- and renal- impairment on plasma protein binding of lenvatinib, and identification of its major plasma binding protein.
来源期刊：Biopharmaceutics & drug dispositionDOI：10.1002/bdd.2204
Species differences in metabolism of a new antiepileptic drug candidate, DSP‐0565 [2‐(2′‐fluoro[1,1′‐biphenyl]‐2‐yl)acetamide]
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2180
Application of a physiologically based pharmacokinetic model for the prediction of mirabegron plasma concentrations in a population with severe renal impairment
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2181
Theoretical consideration of the properties of intestinal flow models on route‐dependent drug removal: Segregated Flow (SFM) vs. Traditional (TM)
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2184
Pharmacokinetic interference of doxorubicin with tolbutamide due to reduced metabolic clearance with increased serum unbound fraction in rats
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2195
Pharmacokinetic profile analyses for inhaled drugs in humans using the lung delivery and disposition model.
来源期刊：Biopharmaceutics & drug dispositionDOI：10.1002/bdd.2210
Strain‐specific altered nicotine metabolism in 3,3′‐diindolylmethane (DIM) exposed mice
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2182
Prediction of clinical effects of infliximab administered for inflammatory bowel disease based on pharmacokinetic and pharmacodynamic modeling
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2198
Pharmacokinetic modeling of the blood‐stable camptothecin analog AR‐67 in two different formulations
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2199
Black tea extract and theaflavin derivatives affect the pharmacokinetics of rosuvastatin by modulating organic anion transporting polypeptide (OATP) 2B1 activity.
来源期刊：Biopharmaceutics & drug dispositionDOI：10.1002/bdd.2202
Biopharmaceutics classification and intestinal absorption of chikusetsusaponin IVa
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2200
Exploring the compatibility mechanism of ShengDiHuang Decoction based on the in situ single-pass intestinal perfusion model.
来源期刊：Biopharmaceutics & drug dispositionDOI：10.1002/bdd.2211
Dasotraline as a Selective Cytochrome 2B6 Inhibitor for Reaction Phenotyping.
来源期刊：Biopharmaceutics & drug dispositionDOI：10.1002/bdd.2207
Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2209
Evaluation of food effect on the oral absorption of clarithromycin from immediate release tablet using physiological modelling
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2176
Metabolite profiling of guanfacine in plasma and urine of healthy Japanese subjects after oral administration of guanfacine extended‐release tablets
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2201
Identification of sulfonyl‐loxoprofen as novel phase 2 conjugate in rat
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2196
Pharmacokinetics and tissue distribution of 3,4‐diaminopyridine in rats
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2203
Irinotecan‐induced gastrointestinal damage impairs the absorption of dabigatran etexilate
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2205
Issue Information
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2144
Association between the pharmacokinetics of capecitabine and the plasma dihydrouracil to uracil ratio in rat: A surrogate biomarker for dihydropyrimidine dehydrogenase activity
来源期刊：Biopharmaceutics & Drug DispositionDOI：10.1002/bdd.2168
