Bioorganic Chemistry publishes research that addresses biological questions at the molecular level, using organic chemistry and principles of physical organic chemistry. The scope of the journal covers a range of topics at the organic chemistry-biology interface, including: enzyme catalysis, biotransformation and enzyme inhibition; nucleic acids chemistry; medicinal chemistry; natural product chemistry, natural product synthesis and natural product biosynthesis; antimicrobial agents; lipid and peptide chemistry; biophysical chemistry; biological probes; bio-orthogonal chemistry and biomimetic chemistry.For manuscripts dealing with synthetic bioactive compounds, the Journal requires that the molecular target of the compounds described must be known, and must be demonstrated experimentally in the manuscript. For studies involving natural products, if the molecular target is unknown, some data beyond simple cell-based toxicity studies to provide insight into the mechanism of action is required. Studies supported by molecular docking are welcome, but must be supported by experimental data. The Journal does not consider manuscripts that are purely theoretical or computational in nature.The Journal publishes regular articles, short communications and reviews. Reviews are normally invited by Editors or Editorial Board members. Authors of unsolicited reviews should first contact an Editor or Editorial Board member to determine whether the proposed article is within the scope of the Journal.
生物有机化学发表的研究，解决生物学问题的分子水平，使用有机化学和物理有机化学的原则。该杂志涵盖有机化学-生物学界面的一系列主题，包括：酶催化、生物转化和酶抑制;核酸化学;药物化学;天然产物化学、天然产物合成和天然产物生物合成;抗微生物剂;脂质和肽化学;生物物理化学;生物探针;生物正交化学和仿生化学。对于涉及合成生物活性化合物的手稿，该杂志要求所述化合物的分子靶标必须是已知的，并且必须在手稿中进行实验证明。对于涉及天然产物的研究，如果分子靶标未知，则需要一些简单的基于细胞的毒性研究以外的数据，以深入了解作用机制。分子对接支持的研究是受欢迎的，但必须有实验数据支持。《日刊》不考虑纯理论或计算性质的稿件。 《日刊》定期发表文章、短通讯和评论。评论通常由编辑或编委会成员邀请。主动评论的作者应首先联系编辑或编辑委员会成员，以确定拟议的文章是否在杂志的范围内。
Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.12.011
Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.12.040
Synthesis, biological evaluation and molecular docking studies of bis-chalcone derivatives as xanthine oxidase inhibitors and anticancer agents.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103149
Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their β1,4-GalT inhibitory and anti-cancer properties.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.11.047
Synthesis, molecular modeling and BACE-1 inhibitory study of tetrahydrobenzo[b] pyran derivatives.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.11.023
Click chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.01.070
Design, synthesis and bioactivity evaluation of coumarin-chalcone hybrids as potential anticancer agents.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103530
Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.02.043
Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.02.037
A molecular hybrid producing simultaneously singlet oxygen and nitric oxide by single photon excitation with green light.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.12.027
Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103565
Biological evaluation and structure activity relationship of 9-methyl-1-phenyl-9H-pyrido[3,4-b]indole derivatives as anti-leishmanial agents
来源期刊：Bioorganic ChemistryDOI：10.1016/j.bioorg.2018.11.037
Bioactive scalemic caged xanthones from the leaves of Garcinia bracteata.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.10.041
Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.02.014
Design, synthesis and anticervical cancer activity of new benzofuran-pyrazol-hydrazono- thiazolidin-4-one hybrids as potential EGFR inhibitors and apoptosis inducing agents.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103035
2-Aryl-quinazolin-4(3H)-ones as an inhibitor of leishmania folate pathway: In vitro biological evaluation, mechanism studies and molecular docking.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.10.028
NO inhibitory phytochemicals as potential anti-inflammatory agents from the twigs of Trigonostemon heterophyllus.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.03.029
Synthesis and evaluation of novel α-substituted chalcones with potent anti-cancer activities and ability to overcome multidrug resistance.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.03.014
Switching of Trp-214 intrinsic rotamer population in human serum albumin: An insight into the aftermath of embracing therapeutic bioorganic luminophore azapodophyllotoxin into sudlow site I.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.11.015
Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103434
Synthesis and biological evaluation of new bisindole-imidazopyridine hybrids as apoptosis inducers.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.03.061
Side-chain cleaved phytoecdysteroid metabolites as activators of protein kinase B.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.10.049
Oleanolic acid oxime derivatives and their conjugates with aspirin modulate the NF-κB-mediated transcription in HepG2 hepatoma cells.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103326
Dihydrofolate reductase inhibition effect of 5-substituted pyrido[2,3-d]pyrimidines: Synthesis, antitumor activity and molecular modeling study.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103076
Discovery of guaiane-type sesquiterpenoids from the roots of Daphne genkwa with neuroprotective effects.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103545
Design, synthesis, biological evaluation and molecular modeling study of new thieno[2,3-d]pyrimidines with anti-proliferative activity on pancreatic cancer cell lines.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103472
Structure-based design and synthesis of new 4-methylcoumarin-based lignans as pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) inhibitors.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.102991
Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.102996
Syntheses and evaluation of new Quinoline derivatives for inhibition of hnRNP K in regulating oncogene c-myc transcription.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2018.12.020
Design and synthesis of novel parabanic acid derivatives as anticonvulsants.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103473
Natural flavonoid α-glucosidase inhibitors from Retama raetam: Enzyme inhibition and molecular docking reveal important interactions with the enzyme active site.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.03.079
Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.102948
Design, synthesis and evaluation of d-amino acid-containing peptidomimetics targeting the polo-box domain of polo-like kinase 1.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.02.022
Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103421
Development of carbapenem-based fluorogenic probes for the clinical screening of carbapenemase-producing bacteria.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103405
Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.01.013
Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103261
Design, synthesis and anti-HBV activity of NVR3-778 derivatives.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103363
The anti-cancer compound Schweinfurthin A targets Osh2 and disrupts lipid metabolism in the yeast model.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103471
Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs.
来源期刊：Bioorganic chemistryDOI：10.1016/J.BIOORG.2019.103163
Synthesis and in vitro antitumor activity of novel acylspermidine derivative N-(4-aminobutyl)-N-(3-aminopropyl)-8-hydroxy-dodecanamide (AAHD) against HepG2 cells.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.102937
Hydrolysis of surfactin over activated carbon.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.03.070
Neurological and psychiatric management using COMT inhibitors: A review.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103418
Exploring calixarene-based clusters for efficient functional presentation of Streptococcus pneumoniae saccharides.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103305
Discovery and optimization of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one derivatives as mTORC1/mTORC2 dual inhibitors.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103232
A solid-phase method for synthesis of dimeric and trimeric ligands: Identification of potent bivalent ligands of 14-3-3σ.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103141
Two novel classes of fused azaisocytosine-containing congeners as promising drug candidates: Design, synthesis as well as in vitro, ex vivo and in silico studies.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103480
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
来源期刊：Bioorganic chemistryDOI：10.1016/J.BIOORG.2019.103135
Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103445
Variedly connected 1,8-naphthalimide-7-chloroquinoline conjugates: Synthesis, anti-mycobacterial and cytotoxic evaluation.
来源期刊：Bioorganic chemistryDOI：10.1016/j.bioorg.2019.103241
