Bioorganic & Medicinal Chemistry Letters presents preliminary experimental or theoretical research results of outstanding significance and timeliness on all aspects of science at the interface of chemistry and biology and on major advances in drug design and development. The journal publishes articles in the form of communications reporting experimental or theoretical results of special interest, and strives to provide maximum dissemination to a large, international audience.
《生物有机与药物化学快报》介绍了在化学和生物学的界面上的科学的各个方面以及药物设计和开发的主要进展方面具有突出意义和及时性的初步实验或理论研究结果。该杂志以通讯的形式发表文章，报告特别感兴趣的实验或理论结果，并努力向大量的国际读者提供最大限度的传播。
Cyclin dependent kinase (CDK) inhibitors as anticancer drugs: Recent advances (2015-2019).
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126637
Quercetin-3-oleoyl derivatives as new GPR40 agonists: Molecular docking studies and functional evaluation.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.05.018
Dual inhibition of Kif15 by oxindole and quinazolinedione chemical probes.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.12.008
Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.03.044
Synthesis and evaluation of a novel quinoline-triazole analogs for antitubercular properties via molecular hybridization approach.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126671
Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.03.050
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.11.044
Discovery of novel 2,3-dihydro-1H-inden-1-amine derivatives as selective monoamine oxidase B inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.02.030
Design, synthesis and biological evaluation of benzimidazole derivatives as novel human Pin1 inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/J.BMCL.2018.11.045
Essential ingredients for rational drug design.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126674
Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.03.048
Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.12.039
Synthesis and in vitro activity of asymmetric indole-based bisamidine compounds against Gram-positive and Gram-negative pathogens.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126887
Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.08.010
Biotinylated-spiperone ligands for quantum dot labeling of the dopamine D2 receptor in live cell cultures.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.02.024
19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.08.020
Diarylcarbonates are a new class of deubiquitinating enzyme inhibitor.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.11.055
Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents
来源期刊：Bioorganic & Medicinal Chemistry LettersDOI：10.1016/j.bmcl.2019.01.035
Structure-based design and discovery of potent and selective lysine-specific demethylase 1 (LSD1) inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.11.001
Synthesis and antitumor activity of daunorubicin conjugates with of 3,4-methylendioxybenzaldehyde.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.08.021
Synthesis and antileishmanial evaluation of thiazole orange analogs.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126725
Incorporation of privileged structures into 3-O-β-chacotriosyl ursolic acid can enhance inhibiting the entry of the H5N1 virus.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.07.028
Novel sulfonamides against Botrytis cinerea with no positive cross-resistance to commercial fungicides: Design, synthesis and SAR study.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126859
Evaluation of quinoxaline compounds as ligands of a site adjacent to S2 (AS2) of cruzain.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.06.046
Upregulation of p53 through induction of MDM2 degradation: Amino acid prodrugs of anthraquinone analogs.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126786
2,4,5-Tris(alkoxyaryl)imidazoline derivatives as potent scaffold for novel p53-MDM2 interaction inhibitors: Design, synthesis, and biological evaluation.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.06.007
Discovery and optimization of covalent Bcl-xL antagonists.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126682
Microwave-assisted synthesis and in vitro stability of N-benzylamide non-steroidal anti-inflammatory drug conjugates for CNS delivery.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.04.016
Functional expression of a highly-reducing polyketide synthase of Emericella variecolor IFM42010, an asteltoxin-producing strain, resulted in production of two polyenoic β-ketolactones with opposite stereochemistry.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126686
Chemically synthesized LYRM03 could inhibit the metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.05.027
Synthesis, fungicidal activity and SAR of 3,4-dichloroisothiazole-based cycloalkylsulfonamides.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.03.047
Serendipitous discovery of aryl boronic acids as β-lactamase inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126795
Prodrugs of the cancer cell selective anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131) are orally efficacious in a mouse model of resistant colon cancer.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.11.053
Synthesis and biological evaluation of 3-amino-, 3-alkoxy- and 3-aryloxy-6-(hetero)arylpyridazines as potent antitumor agents.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.12.050
Identification of BR101549 as a lead candidate of non-TZD PPARγ agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.12.043
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.07.013
Discovery of 1,8-disubstituted-[1,2,3]triazolo[4,5-c]quinoline derivatives as a new class of Hippo signaling pathway inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.08.001
Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126788
Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126818
Synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel FMS inhibitors.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.11.037
Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126812
SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.06.032
Design, synthesis and biological evaluation of mogrol derivatives as a novel class of AMPKα2β1γ1 activators.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126790
Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.03.052
Synthesis of 2-arylhydrazinylidene-3-oxo-4,4,4-trifluorobutanoic acids as new selective carboxylesterase inhibitors and radical scavengers.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126716
Synthesis and biological evaluation of Vinpocetine derivatives.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/J.BMCL.2019.05.052
Facile synthesis of carbon-11-labeled sEH/PDE4 dual inhibitors as new potential PET agents for imaging of sEH/PDE4 enzymes in neuroinflammation.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.04.036
Targeting TRAIL.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.07.053
Synthesis and antitumor activity of bis(arylsulfonyl)dihydroimidazolinone derivatives.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2019.126776
The role of N-terminal heterocycles in hydrogen bonding to α-chymotrypsin.
来源期刊：Bioorganic & medicinal chemistry lettersDOI：10.1016/j.bmcl.2018.12.032
