Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides.The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.
《生物有机与药物化学》是一个国际性的学术论坛，发表有关受体、通道、酶、核苷酸、脂类和糖类等关键生物靶点分子间相互作用的原创性研究论文和评论。该杂志的目的是促进对生命过程、生物体及其与化学试剂相互作用的分子水平的更好理解。一个特别的特点是，彩色插图将免费复制给作者，只要编辑同意颜色是必要的信息内容的插图。
Identification and design of novel small molecule inhibitors against MERS-CoV papain-like protease via high-throughput screening and molecular modeling
来源期刊：Bioorganic & Medicinal ChemistryDOI：10.1016/j.bmc.2019.03.050
Synthesis and characterization of pyridoxine, nicotine and nicotinamide salts of dithiophosphoric acids as antibacterial agents against resistant wound infection.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2018.11.017
New SIRT2 inhibitors: Histidine-based bleomycin spin-off.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.03.003
The design of 1,4-naphthoquinone derivatives and mechanisms underlying apoptosis induction through ROS-dependent MAPK/Akt/STAT3 pathways in human lung cancer cells.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.03.002
Betulinic acid induces apoptosis and inhibits metastasis of human colorectal cancer cells in vitro and in vivo.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.03.033
New hybrid trifluoromethylquinolines as antiplasmodium agents.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.044
Design, synthesis, in-silico studies and biological screening of quinazolinone analogues as potential antibacterial agents against MRSA.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.012
Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.07.035
Synthesis of amides from (E)-3-(1-chloro-3,4-dihydronaphthalen-2-yl)acrylic acid and substituted amino acid esters as NorA efflux pump inhibitors of Staphylococcus aureus.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2018.12.008
Design, synthesis and antimycobacterial activity of less lipophilic Q203 derivatives containing alkaline fused ring moieties.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.022
Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/J.BMC.2019.07.015
Novel alkoxyamide-based histone deacetylase inhibitors reverse cisplatin resistance in chemoresistant cancer cells.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115108
Veratric acid derivatives containing benzylidene-hydrazine moieties as promising tyrosinase inhibitors and free radical scavengers.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.04.016
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.03.060
Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.04.028
Enantioselective resolution of side-chain modified gem-difluorinated alcohols catalysed by Candida antarctica lipase B and monitored by capillary electrophoresis.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.02.022
Predictive models of aqueous solubility of organic compounds built on A large dataset of high integrity.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.037
Design, synthesis and antitumour and anti-angiogenesis evaluation of 22 moscatilin derivatives.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.04.027
Synthesis of N-hydroxycinnamoyl amide derivatives and evaluation of their anti-oxidative and anti-tyrosinase activities.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/J.BMC.2019.05.031
2-Aryladenine derivatives as a potent scaffold for A1, A3 and dual A1/A3 adenosine receptor antagonists: Synthesis and structure-activity relationships.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.06.034
Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115126
Design, synthesis and biological evaluation of novel aryl-acrylic derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.048
Design, synthesis and anti-inflammatory evaluation of novel pyrrolo[2,3-d]pyrimidin derivatives as potent JAK inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.07.037
Identification of potent pyrazole based APELIN receptor (APJ) agonists.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115237
Developing new hybrid scaffold for urease inhibition based on carbazole-chalcone conjugates: Synthesis, assessment of therapeutic potential and computational docking analysis.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115123
Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.013
Leucine ureido derivatives as aminopeptidase N inhibitors using click chemistry. Part II.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.041
Fluorogenic approach to evaluating prodrug hydrolysis and stability in live cells.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.030
Synthesis and bioactivity of 1,3-thiazolidine-2-thione derivatives against type III secretion system of Xanthomonas oryzae.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.06.019
Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.06.026
Use of a deoxynojirimycin-fluorophore conjugate as a cell-specific imaging probe targeting α-glucosidase on cell membranes.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.032
Identification of antimalarial leads with dual falcipain-2 and falcipain-3 inhibitory activity.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115155
Small-molecule inhibitors of nisin resistance protein NSR from the human pathogen Streptococcus agalactiae.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115079
Expansion of a novel lead targeting M. tuberculosis DHFR as antitubercular agents.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.02.053
Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.002
Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor.
来源期刊：Bioorganic & Medicinal ChemistryDOI：10.2210/PDB6MO7/PDB
Lead optimization of selective tubulin inhibitors as anti-trypanosomal agents.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.02.049
Development of novel macrocyclic small molecules that target CTG trinucleotide repeats.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.022
Tetrahydroquinoline units in flexible heteroarotinoids (Flex-Hets) convey anti-cancer properties in A2780 ovarian cancer cells.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115244
Modelling the binding mode of macrocycles: Docking and conformational sampling.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115143
Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115260
Discovery of pyrimidine nucleoside dual prodrugs and pyrazine nucleosides as novel anti-HCV agents.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.007
Chemical synthesis and functional characterization of a new class of ceramide analogues as anti-cancer agents.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.02.030
Reaction of thymidine and ascorbic acid induced by UV in the presence of salicylic acid.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115046
Design and synthesis of sulfonamidophenylethylamides as novel cardiac myosin activator.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.07.041
Discovery of 2,4-diamino-5-cyanopyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.01.019
Investigating the effect of radiosensitizer for Ursolic Acid and Kamolonol Acetate \u200c on HCT-116 cell line.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115152
Fluorine-18 (18F)-labeled retinoid\u202fx\u202freceptor (RXR) partial agonist whose tissue transferability is affected by other RXR ligands.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.05.045
Electron injection from mitochondrial transcription factor A to DNA associated with thymine dimer photo repair.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2018.11.044
Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors.
来源期刊：Bioorganic & medicinal chemistryDOI：10.1016/j.bmc.2019.115257
