Biochemistry为生物化学领域提供发表优秀、严谨、高影响力研究内容的国际平台。 研究范围包括对生物或细胞功能的化学、物理、机械和/或结构基础的研究，并包含化学生物学、合成生物学、疾病生物学、细胞生物学、核酸生物学、神经科学、结构生物学和生物物理学等领域。除了传统的研究文章外，Biochemistry还出版Communications, Viewpoints, 和Perspectives，以及From the Bench等报告生物化学界引人关注的新方法的文章。Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.
生物化学提供了一个国际论坛，发表特殊的，严格的，高影响力的研究，在所有的生物化学。这一广泛的范围包括对生物学或细胞功能的化学、物理、机械和/或结构基础的研究，并涵盖化学生物学、合成生物学、疾病生物学、细胞生物学、核酸生物学、神经科学、结构生物学和生物物理学领域。除了传统的研究文章外，《生物化学》还出版通讯、观点和展望，以及报告生物化学界特别感兴趣的新方法的来自实验室的文章。
Kinetics of Ligand-Protein Dissociation from All-Atom Simulations: Are We There Yet?
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b00977
Biaryl-Forming Enzymes from Aspergilli Exhibit Substrate-Dependent Stereoselectivity.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00291
An Open-Source Plate Reader.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b00952
PIP2 Influences the Conformational Dynamics of Membrane bound KRAS4b.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00395
Taking toll on membranes: curious cases of bacterial β-barrel pore-forming toxins.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00783
Structural Basis for Rare Earth Element Recognition by Methylobacterium extorquens Lanmodulin.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01019
Structure of a ferryl mimic in the archetypal iron(II)- and 2-(oxo)-glutarate-dependent dioxygenase, TauD.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00598
Eight-Letter DNA.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00274
A Disease-Causing Intronic Point Mutation C19G Alters Tau Exon 10 Splicing via RNA Secondary Structure Rearrangement.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00001
On Force and Form: Mechano-Biochemical Regulation of Extracellular Matrix.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00219
Nonphotosynthetic Biological CO2 Reduction.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b00937
A Lysine-Targeted Affinity Label for Serine-β-Lactamase Also Covalently Modifies New Delhi Metallo-β-lactamase-1 (NDM-1).
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00393
Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01231
Bacterial Tetrabromopyrrole Debrominase Shares a Reductive Dehalogenation Strategy with Human Thyroid Deiodinase.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00318
Role of Gln114 in Spectral Tuning of a Long-Wavelength Sensitive Visual Pigment.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00340
Structural and Antiviral Studies of the Human Norovirus GII.4 Protease.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01063
Insights into Thiotemplated Pyrrole Biosynthesis Gained from the Crystal Structure of Flavin-Dependent Oxidase in Complex with Carrier Protein.
来源期刊：BiochemistryDOI：10.2210/PDB6CY8/PDB
Detection of Incorporation of p-Coumaric Acid into Photoactive Yellow Protein Variants in Vivo.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00279
Identification of Filamin A Mechanobinding Partner I: Smoothelin Specifically Interacts with the Filamin A Mechanosensitive Domain 21.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00100
Incorporating 2-thiouracil into short dsRNA-binding PNAs for enhanced recognition of A-U pairs and for targeting a microRNA hairpin precursor.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00521
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b00950
3D protein structure determination using pseudocontact shifts of backbone amide protons generated by double-histidine Co2+-binding motifs at multiple sites.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00404
Multiplex Genome Engineering for Optimizing Bioproduction in Saccharomyces cerevisiae.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01086
Restoration of miRNA-149 Expression by TmPyP4 Induced Unfolding of Quadruplex within Its Precursor.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b00880
Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01122
Aerobic Enzymes and Their Radical SAM Enzyme Counterparts in Tetrapyrrole Pathways.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b00906
Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS.
来源期刊：BiochemistryDOI：10.2210/PDB6MRH/PDB
Water networks and correlated motions in mutant IDH1 are critical for allosteric inhibitor binding and activity.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b01023
Glycosaminoglycans Induce Amyloid Self-Assembly of a Peptide Hormone by Concerted Secondary and Quaternary Conformational Transitions.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01206
Munc13 Is a Molecular Target of Bryostatin 1.
来源期刊：BiochemistryDOI：10.1021/ACS.BIOCHEM.9B00427
Human Antibody Bispecifics through Phage Display Selection.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00037
A Fold-Independent Interface Residue Is Crucial for Complex Formation and Allosteric Signaling in Class I Glutamine Amidotransferases.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00286
Overexpression of Osmosensitive Ca2+-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00224
Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00130
Crossing the First Threshold: New Insights into the Influence of the Chemical Structure of Anionic Porphyrins on Plant Cell Wall Interactions and Photodynamic Cell Death Induction.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00107
New Insight Into the Mechanism of Anaerobic Heme Degradation.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00841
Calmodulin/Calcineurin Interaction Beyond the Calmodulin-binding Region Contributes to Calcineurin Activation.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00626
Combined Solution and Crystal Methods Reveal the Electrostatic Tethers That Provide a Flexible Platform for Replication Activities in the Bacteriophage T7 Replisome.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00525
Catalytic Cycle of Neisseria meningitidis CMP-Sialic Acid Synthetase Illustrated by High-Resolution Protein Crystallography.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00517
Synthesis and Target Identification of a Novel Electrophilic Warhead, 2-Chloromethylquinoline.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00359
Stiffness of cargo-motor linkage tunes Myosin VI motility and response to load.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00422
Structural and Functional Characterization of Sulfonium Carbon-Oxygen Hydrogen Bonding in the Deoxyamino Sugar Methyltransferase TylM1.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01141
A Microfluidic-Based Microscopy Platform for Continuous Interrogation of Trypanosoma brucei during Environmental Perturbation.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01269
TALEN-based chemically inducible, dimerization-dependent, sequence-specific nucleases.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00798
Structural Energy Landscapes and Plasticity of the Microstates of Apo E. coli cAMP Receptor Protein.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00895
Reversible membrane-tethering by ZipA determines FtsZ polymerization in two and three dimensions.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00378
Structural, Kinetic, and Mechanistic Analysis of an Asymmetric 4-Oxalocrotonate Tautomerase Trimer.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00303
Propagation of the Allosteric Signal in Phosphofructokinase from Bacillus stearothermophilus Examined by Methyl-TROSY NMR.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.9b00229
Synthetic Biology Approaches in Immunology.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01081
Deciphering the Enzymatic Function of the Bovine Enteric Infection-Related Protein YfeJ from Salmonella enterica Serotype Typhimurium.
来源期刊：BiochemistryDOI：10.1021/acs.biochem.8b01283
