Biochemical Pharmacology publishes original research findings, Commentaries and review articles related to the elucidation of cellular and tissue function(s) at the biochemical and molecular levels, the modification of cellular phenotype(s) by genetic, transcriptional/translational or drug/compound-induced modifications, as well as the pharmacodynamics and pharmacokinetics of xenobiotics and drugs, the latter including both small molecules and biologics.The journal's target audience includes scientists engaged in the identification and study of the mechanisms of action of xenobiotics, biologics and drugs and in the drug discovery and development process.All areas of cellular biology and cellular, tissue/organ and whole animal pharmacology fall within the scope of the journal. Drug classes covered include anti-infectives, anti-inflammatory agents, chemotherapeutics, cardiovascular, endocrinological, immunological, metabolic, neurological and psychiatric drugs, as well as research on drug metabolism and kinetics. While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review.While particular emphasis is placed on reporting the results of molecular and biochemical studies, research involving the use of tissue and animal models of human pathophysiology and toxicology is of interest to the extent that it helps define drug mechanisms of action, safety and efficacy.
生物化学药理学发表原始研究发现，评论和评论文章有关阐明细胞和组织功能（s）在生化和分子水平上，修饰细胞表型（s）通过遗传、转录/翻译或药物/化合物诱导的修饰，以及异生素和药物的药效学和药代动力学，后者包括小分子和生物学。该杂志的目标读者包括从事异生素、生物学和药物作用机制的鉴定和研究以及药物发现和开发过程的科学家。细胞生物学和细胞、组织/器官和整个动物药理学属于该杂志的范围。涵盖的药物类别包括抗感染药、抗炎药、化疗药、心血管药、内分泌药、免疫药、代谢药、神经药和精神病药，以及药物代谢和动力学研究。虽然药物化学是一个令人感兴趣的主题，但该领域的手稿必须包含足够的生物学数据，以表征所报告化合物的药理学特征。对主要集中在化学合成和分子建模方面的工作进行描述的提交材料将不会被考虑进行审查。虽然特别强调报告分子和生化研究的结果，但涉及使用人体病理生理学和毒理学的组织和动物模型的研究在一定程度上有助于确定药物的作用机制、安全性和有效性，因此也是令人感兴趣的。
A delicate balance - The BCL-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.01.015
Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2018.11.004
Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin‐1/NF‐&kgr;B/c‐Myc pathway
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2019.01.016
Mechanisms of aging and potential role of selected polyphenols in extending healthspan.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113719
Paricalcitol alleviates lipopolysaccharide‐induced depressive‐like behavior by suppressing hypothalamic microglia activation and neuroinflammation
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2019.01.021
Targeting the autotaxin - Lysophosphatidic acid receptor axis in cardiovascular diseases.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.03.035
Late autophagy inhibitor chloroquine improves efficacy of the histone deacetylase inhibitor SAHA and temozolomide in gliomas
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2019.03.015
Revisiting the combinatorial potential of cytokine subunits in the IL-12 family.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.03.026
Immune-mediated anti-tumor effects of metformin; targeting metabolic reprogramming of T cells as a new possible mechanism for anti-cancer effects of metformin.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113787
Anti‐tumor effect of sulfasalazine in neuroblastoma
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2019.01.007
Olesoxime in Neurodegenerative Diseases: Scrutinising a Promising Drug Candidate.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.07.002
Targeting ADP-ribosylation as an antimicrobial strategy
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2019.06.001
The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113687
Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.04.021
Small molecules for great solutions: Can nitric oxide-releasing nanomaterials overcome drug resistance in chemotherapy?
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113740
Olean-28,13b-olide 2 plays a role in cisplatin-mediated apoptosis and reverses cisplatin resistance in human lung cancer through multiple signaling pathways.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113642
Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.05.011
M3 Muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβ/AMPK pathway.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.08.015
Inhibition of human UDP-glucuronosyltransferase (UGT) enzymes by kinase inhibitors: Effects of dabrafenib, ibrutinib, nintedanib, trametinb and BIBF 1202.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.08.018
Tofacitinib and TPCA-1 exert chondroprotective effects on extracellular matrix turnover in bovine articular cartilage ex vivo.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2018.07.034
Synthesis and in vivo antitumor evaluation of an orally active potent phosphonamidate derivative targeting IDO1/IDO2/TDO.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.07.011
Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113641
Adenosinergic Signalling In Chondrogenesis And Cartilage Homeostasis: Friend Or Foe?
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113784
The pyrrolopyrimidine colchicine‐binding site agent PP‐13 reduces the metastatic dissemination of invasive cancer cells in vitro and in vivo
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2018.12.004
15-Deoxy-Δ-12, 14-prostaglandin J2 acts cooperatively with prednisolone to reduce TGF-β-induced pro-fibrotic pathways in human osteoarthritis fibroblasts.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.03.039
High-content Analysis of Constitutive Androstane Receptor (CAR) Translocation Identifies Mosapride Citrate as a CAR Agonist that Represses Gluconeogenesis.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.07.013
A novel iron(II) phenanthroline complex exhibits anticancer activity against TFR1-overexpressing esophageal squamous cell carcinoma cells through ROS accumulation and DNA damage.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.05.013
Modulation of Sirt1/NF-κB interaction of evogliptin is attributed to inhibition of vascular inflammatory response leading to attenuation of atherosclerotic plaque formation.
来源期刊：Biochemical PharmacologyDOI：10.1016/J.BCP.2019.08.008
Oxyresveratrol drives caspase-independent apoptosis-like cell death in MDA-MB-231 breast cancer cells through the induction of ROS.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113724
Generation of endoplasmic reticulum stress and inhibition of autophagy by plitidepsin induces proteotoxic apoptosis in cancer cells.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113744
NG2-glia cell proliferation and differentiation by glial growth factor 2 (GGF2), a strategy to promote functional recovery after ischemic stroke.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113720
The regulatory roles of calcium channels in tumors.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.08.005
Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.06.011
S-nitrosoglutathione prevents cognitive impairment through epigenetic reprogramming in ovariectomised mice.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.07.022
Inorganic polyphosphate protects against lipopolysaccharide‐induced lethality and tissue injury through regulation of macrophage recruitment
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2018.11.017
Impairment of chemical hypoxia-induced sphingosine kinase-1 expression and activation in rheumatoid arthritis synovial fibroblasts: A signature of exhaustion?
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.02.009
Protein-protein interactions of drug uptake transporters that are important for liver and kidney.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.07.026
The marmoset cytochrome P450 superfamily: sequence/phylogenetic analyses, genomic structure, and catalytic function.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113721
Acute Acetaminophen Intoxication Induces Direct Neurotoxicity in Rats Manifested as Astrogliosis and Decreased Dopaminergic Markers in Brain Areas Associated With Locomotor Regulation.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113662
Serine residues in the &agr;4 nicotinic acetylcholine receptor subunit regulate surface &agr;4&bgr;2* receptor expression and clustering
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2018.11.008
Mechanisms of Gemcitabine Oral Absorption as Determined by In Situ Intestinal Perfusions in Mice.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.06.013
Atypical Michaelis-Menten kinetics in cytochrome P450 enzymes: a focus on substrate inhibition.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.08.017
The role of α7nAChR in controlling the anti-inflammatory/anti-arthritic action of Galantamine.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113665
Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.03.014
WNK4-SPAK modulates lipopolysaccharide-induced macrophage activation.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113738
RJT-101, a novel camptothecin derivative, is highly effective in the treatment of melanoma through DNA damage by targeting Topoisomerase 1.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113716
Inhibition of lipolysis: a novel explanation for the hypothermic actions of Acetaminophen in Non-Febrile Rodents.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113774
Orabase-formulated Gentian Violet Effectively Improved Oral Potentially Malignant Disorder in vitro and in vivo.
来源期刊：Biochemical pharmacologyDOI：10.1016/j.bcp.2019.113713
Kick and Kill Approach: How Far are we from HIV Cure?
来源期刊：Biochemical PharmacologyDOI：10.35248/2167-0501.19.8.e188
The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions
来源期刊：Biochemical PharmacologyDOI：10.1016/j.bcp.2019.02.018
