Basic & Clinical Pharmacology and Toxicology is an independent journal, publishing original scientific research in all fields of toxicology, basic and clinical pharmacology. This includes experimental animal pharmacology and toxicology and molecular (-genetic), biochemical and cellular pharmacology and toxicology. It also includes all aspects of clinical pharmacology: pharmacokinetics, pharmacodynamics, therapeutic drug monitoring, drug/drug interactions, pharmacogenetics/-genomics, pharmacoepidemiology, pharmacovigilance, pharmacoeconomics, randomized controlled clinical trials and rational pharmacotherapy. For all compounds used in the studies, the chemical constitution and composition should be known, also for natural compounds.
基础与临床药理学和毒理学是一个独立的杂志，发表原创的科学研究，在所有领域的毒理学，基础和临床药理学。这包括实验动物药理学和毒理学以及分子（遗传）、生化和细胞药理学和毒理学。它还包括临床药理学的所有方面：药物动力学、药效学、治疗药物监测、药物/药物相互作用、药物遗传学/基因组学、药物流行病学、药物警戒、药物经济学、随机对照临床试验和合理药物治疗。对于研究中使用的所有化合物，化学结构和组成应该是已知的，对于天然化合物也是如此。
Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long‐term impairment of the GIP system
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13289
Neurotoxic effects of mercury exposure in dental personnel.
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13199
Are radio‐contrast agents commonly used in discography toxic to the intact intervertebral disc tissue cells?
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13112
Protective effect of isochlorogenic acid B on liver fibrosis in non‐alcoholic steatohepatitis of mice
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13122
Cryptotanshinone ameliorates renal ischaemia–reperfusion injury by inhibiting apoptosis and inflammatory response
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13275
Apelin peptides linked to anti‐serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13227
Association between dopamine receptor gene polymorphisms and effects of risperidone treatment: A systematic review and meta‐analysis
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13111
Immunological and pathological effects of electronic cigarettes.
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13225
MKP‐1 promotes anti‐inflammatory M(IL‐4/IL‐13) macrophage phenotype and mediates the anti‐inflammatory effects of glucocorticoids
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13163
Come Fly with Me: an overview of dopamine receptors in Drosophila melanogaster.
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13277
Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13235
Lamotrigine drug interactions in combination therapy and the influence of therapeutic drug monitoring on clinical outcomes in paediatric patients
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13203
Aspirin for the prevention and treatment of pre‐eclampsia: A matter of COX‐1 and/or COX‐2 inhibition?
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13308
Hypoxic augmentation: the tale of a strange contraction.
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13295
Statin use and peripheral nerve function—A prospective follow‐up study
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13320
Porcine cytochrome 2A19 and 2E1
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13121
Signalling pathways involved in p47phox‐dependent reactive oxygen species in platelets of endotoxemic rats
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13148
Correlation of registered drug packs with Maastricht V/Florence Consensus Report and national treatment guidelines for management of Helicobacter pylori infection
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13322
Electronic assessment of cardiovascular potentially inappropriate medications in an administrative population database
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13095
Identification of compounds that inhibit the binding of Keap1a/Keap1b Kelch DGR domain with Nrf2 ETGE/DLG motifs in zebrafish
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13222
Lung alveolar tissue destruction and protein citrullination in diesel exhaust‐exposed mouse lungs
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13213
Evaluation of DNA damage in spinal cord and mutagenic effect of a Phα1β recombinant toxin with analgesic properties from the Phoneutria nigriventer spider
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13171
Progression-free survival in oncology: Caveat emptor!
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13168
MIDD0301 – A first‐in‐class anti‐inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13206
Association between genetic polymorphisms of SLCO1B1 and susceptibility to methimazole‐induced liver injury
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13284
Population pharmacokinetics and dosing regimen optimisation of lopinavir in Chinese adults infected with HIV
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13154
Optimal teicoplanin loading regimen to rapidly achieve target trough plasma concentration in critically ill patients
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13338
Treatment with lecinoxoids attenuates focal and segmental glomerulosclerosis development in nephrectomized rats
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13114
The predictive value of scores based on peripheral complete blood cell count for long‐term neurological outcome in acute carbon monoxide intoxication
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13157
Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13339
Stanozolol promotes lipid deposition in the aorta through an imbalance in inflammatory cytokines and oxidative status in LDLr knockout mice fed a normal diet
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13143
Extracorporeal treatments in poisonings from four non‐traditionally dialysed toxins (acetaminophen, digoxin, opioids and tricyclic antidepressants): A combined single‐centre and national study
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13135
Patient‐ and health care‐related factors associated with initiation of potentially inappropriate medication in community‐dwelling older persons
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13096
Drugs for hyperlipidaemia may slow down the progression of hearing loss in the elderly: A drug repurposing study
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13150
Effect of glutathione S‐transferase genetic polymorphisms on busulfan pharmacokinetics and veno‐occlusive disease in hematopoietic stem cell transplantation: A meta‐analysis
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13185
Pre‐clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion‐induced toxicity
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13359
Prevalence and determinants of uptake of folic acid in peri‐conceptional period in a rural lower‐middle‐income country, Ghana
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13331
Duplicated tramadol use in chronic low back pain: A nationwide cross‐sectional study
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13324
Discontinuation of antidepressants in suicides findings from the Friuli Venezia Giulia Region, Italy, 2005‐2014
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13140
Optimizing spontaneous adverse drug reaction reporting in public healthcare setting in Namibia
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13325
A data science approach to the selection of most informative readouts of the human intradermal capsaicin pain model to assess pregabalin effects
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13337
The effect of perazine on the CYP2D6 and CYP2C19 phenotypes as measured by the dextromethorphan and mephenytoin tests in psychiatric patients
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13373
Differences in preventing new‐onset cardiovascular events with statin therapy in seniors aged 75 years and over: A cohort study in the South Korean National Health Insurance Database
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13229
Doxazosin down‐regulates sodium‐glucose cotransporter‐2 and exerts a renoprotective effect in rat models of acute renal injury
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13371
Drug information centre queries and responses about drug interactions over 10 years—A descriptive analysis
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13294
Post‐marketing assessment of generic tamoxifen in Brazilian breast cancer patients
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13368
Is an increased PaO2 in a normobaric state safe in acute CO poisoning?
来源期刊：Basic & clinical pharmacology & toxicologyDOI：10.1111/bcpt.13361
Genetic insight into cytochrome P450 in Chinese from the Chinese Millionome Database
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13356
Sotalol, unlike the other beta‐blockers, increases the QTc interval and risk of torsades de pointes ventricular tachycardia in severe poisonings
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13333
Population pharmacokinetic‐pharmacodynamic modelling of liquid and controlled‐release formulations of oxycodone in healthy volunteers
来源期刊：Basic & Clinical Pharmacology & ToxicologyDOI：10.1111/bcpt.13330
