Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.
当代生命科学的许多研究都致力于从分子尺度上理解基因与环境之间的关系--特别是包括蛋白质在内的细胞效应物的水平、修饰和相互作用的动态变化。《分子生物科学前沿》为基础研究和应用研究提供了一个国际出版平台;我们鼓励跨已建立和新兴的生物学领域的贡献。为此,该杂志借鉴了经验学科,如结构生物学、酶学、生物化学和生物物理学,并利用了技术进步,使代谢组学和蛋白质组学测量能够在大规模并行通量,并开发了强大和创新的计算生物学策略。我们也认识到来自医学和技术的影响,欢迎在分子遗传学、分子诊断和治疗学以及纳米技术方面的研究。我们的最终目标是全面阐述生物体中蛋白质、核酸、碳水化合物、脂质和小代谢物的分子调节机制。除了有趣的新发现,技术和应用,前沿分子生物科学将考虑新的可测试的假设,以激发不同的观点和刺激科学对话。计算机模拟、体外和体内方法的整合将有利于生命科学所有领域的努力。
Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00160
DNA Uptake by Type IV Filaments
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00001
Post-transcriptional Regulation of Colorectal Cancer: A Focus on RNA-Binding Proteins
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00065
Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00061
Integration of Random Forest Classifiers and Deep Convolutional Neural Networks for Classification and Biomolecular Modeling of Cancer Driver Mutations
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00044
Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00120
Immunometabolism and Sepsis: A Role for HIF?
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00085
Emerging Functions of Human IFIT Proteins in Cancer
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00148
Using Dimensionality Reduction to Analyze Protein Trajectories
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00046
100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00058
Site-Directed Fluorescence Approaches for Dynamic Structural Biology of Membrane Peptides and Proteins
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00096
Dynamics Insights Into the Gain of Flexibility by Helix-12 in ESR1 as a Mechanism of Resistance to Drugs in Breast Cancer Cell Lines
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00159
Understanding Ligand Binding to G-Protein Coupled Receptors Using Multiscale Simulations
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00029
Biofunctionalization of Silver Nanoparticles With Lactonase Leads to Altered Antimicrobial and Cytotoxic Properties
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00063
Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00018
Atomic Motif Recognition in (Bio)Polymers: Benchmarks From the Protein Data Bank
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00024
Impact of Cancer-Associated Fibroblast on the Radiation-Response of Solid Xenograft Tumors
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00070
Computational Studies of Cardiac and Skeletal Troponin
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00068
Structure and Gating Dynamics of Na+/Cl– Coupled Neurotransmitter Transporters
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00080
Adhesions Assemble!—Autoinhibition as a Major Regulatory Mechanism of Integrin-Mediated Adhesion
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00144
Yeast Models for the Study of Amyloid-Associated Disorders and Development of Future Therapy
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00015
Topological Constraints in Eukaryotic Genomes and How They Can Be Exploited to Improve Spatial Models of Chromosomes
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00127
N-glycomic Complexity in Anatomical Simplicity: Caenorhabditis elegans as a Non-model Nematode?
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00009
The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. Implications for Their Immunogenicity in Clinical Xenografting
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00057
MiR-92a Family: A Novel Diagnostic Biomarker and Potential Therapeutic Target in Human Cancers
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00098
The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00095
Contribution of Mitochondrial DNA Variation to Chronic Disease in East Asian Populations
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00128
Including Protons in Solid-State NMR Resonance Assignment and Secondary Structure Analysis: The Example of RNA Polymerase II Subunits Rpo4/7
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00100
Assembly of Spinach Chloroplast ATP Synthase Rotor Ring Protein-Lipid Complex
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00135
RARG Gene Dysregulation in Acute Myeloid Leukemia
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00114
Conservation of Prion-Like Composition and Sequence in Prion-Formers and Prion-Like Proteins of Saccharomyces cerevisiae
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00054
MARTINI-Based Protein-DNA Coarse-Grained HADDOCKing
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00102
Human Serine Racemase: Key Residues/Active Site Motifs and Their Relation to Enzyme Function
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00008
Spatial Organization of Proteasome Aggregates in the Regulation of Proteasome Homeostasis
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00150
Gender-Related Differences in Sickle Cell Disease in a Pediatric Cohort: A Single-Center Retrospective Study
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00140
Metabolic Insights Into the Effects of Nutrient Stress on Lactobacillus plantarum B21
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00075
Alternative Splicing of MXD3 and Its Regulation of MXD3 Levels in Glioblastoma
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00005
New Perspectives on Plant Adenylyl Cyclases
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00136
Phosphorylation and Alternative Translation on Wheat Germ Cell-Free Protein Synthesis of the DHBV Large Envelope Protein
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00138
Modeling Electrostatic Force in Protein-Protein Recognition
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00094
ALTernative Functions for Human FANCM at Telomeres
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00084
Protein Folding Modulation in Cells Subject to Differentiation and Stress
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00038
Structural Transition States Explored With Minimalist Coarse Grained Models: Applications to Calmodulin
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00104
Editorial: Aromatic Amino Acid Metabolism
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00022
Editorial: Bacterial Mechanisms of Antibiotic Resistance: A Structural Perspective
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00071
Association of Mental Health-Related Proteins DAXX, DRD3, and DISC1 With the Progression and Prognosis of Chondrosarcoma
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00134
Unraveling the Molecular Mechanism of Pre-mRNA Splicing From Multi-Scale Simulations
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00062
Harmonic Generation Microscopy 2.0: New Tricks Empowering Intravital Imaging for Neuroscience
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00099
Glucose-6-Phosphate Upregulates Txnip Expression by Interacting With MondoA
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00147
Ribosome Evolution and Structural Capacitance
来源期刊:Frontiers in Molecular BiosciencesDOI:10.3389/fmolb.2019.00123