Fluids and Barriers of the CNS is an open access, peer-reviewed journal that considers manuscripts on all CNS fluids and barrier systems in health and disease.Homeostatic maintenance of the internal environment of the nervous system through normal functioning of brain fluids and barriers is vital for health of the organism. The cerebrospinal fluid (CSF), its composition, circulation and absorption, has multiple roles in both normal and abnormal brain function and is closely associated with the parenchymal interstitial fluid and the neurovascular unit at the blood-brain barrier. The CNS fluids and barrier systems including the blood-CSF barrier, the blood-brain barrier, the blood-retinal barrier and the blood-nerve barriers, perform functions such as fluid secretion, chemical signalling, physical and chemical buffering, specialised directional transport and facilitation of immune surveillance.
中枢神经系统的液体和屏障是一个开放获取，同行评审的杂志，考虑手稿的所有中枢神经系统液体和屏障系统的健康和疾病。稳态维持神经系统的内部环境通过正常功能的脑液和屏障是至关重要的有机体的健康。脑脊液（CSF ）的组成、循环和吸收在正常和异常脑功能中具有多重作用，并且与实质间质液和血脑屏障上的神经血管单元密切相关。CNS液体和屏障系统包括血- CSF屏障、血-脑屏障、血-视网膜屏障和血-神经屏障，执行诸如液体分泌、化学信号传导、物理和化学缓冲、专门定向运输和促进免疫监视的功能。
Claudin-5: gatekeeper of neurological function
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0123-z
Analysis of convective and diffusive transport in the brain interstitium
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0126-9
Claudin-12 is not required for blood–brain barrier tight junction function
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0150-9
Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0132-y
An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0145-6
Cerebrospinal fluid dynamics and intracranial pressure elevation in neurological diseases
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0129-6
Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0136-7
Hydraulic resistance of periarterial spaces in the brain
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0140-y
The need for mathematical modelling of spatial drug distribution within the brain
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0133-x
The role of mutations associated with familial neurodegenerative disorders on blood–brain barrier function in an iPSC model
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0139-4
Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0160-7
Spinal CSF flow in response to forced thoracic and abdominal respiration
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0130-0
Streptococcus agalactiae disrupts P-glycoprotein function in brain endothelial cells
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0146-5
Preclinical update on regulation of intracranial pressure in relation to idiopathic intracranial hypertension
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0155-4
The Kuopio idiopathic normal pressure hydrocephalus protocol: initial outcome of 175 patients
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0142-9
Comorbidity of diabetes mellitus in idiopathic normal pressure hydrocephalus: a systematic literature review
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0125-x
Enhanced xeno-free differentiation of hiPSC-derived astroglia applied in a blood–brain barrier model
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0147-4
Opposing CSF hydrodynamic trends found in the cerebral aqueduct and prepontine cistern following shunt treatment in patients with normal pressure hydrocephalus
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0122-0
Effect of extradural constriction on CSF flow in rat spinal cord
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0127-8
B waves: a systematic review of terminology, characteristics, and analysis methods
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0153-6
The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0134-9
A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0137-6
Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0152-7
Repeated lumbar punctures within 3 days may affect CSF biomarker levels
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0157-2
Enhanced in vitro model of the CSF dynamics
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0131-z
Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0148-3
The year in review: progress in brain barriers and brain fluid research in 2018
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0124-y
Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0158-1
The human central nervous system discharges carbon dioxide and lactic acid into the cerebrospinal fluid
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0128-7
Human ES-derived MSCs correct TNF-α-mediated alterations in a blood–brain barrier model
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0138-5
Effect of blood contamination of cerebrospinal fluid on amino acids, biogenic amines, pterins and vitamins
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0154-5
The legacy of Malcolm Beverley Segal (1937–2019) on the science and fields concerned with choroid plexus and cerebrospinal fluid physiology
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0161-6
In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0143-8
Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0159-0
Abstracts from the 13th International Conference on Cerebral Vascular Biology (CVB 2019)
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0135-8
Abstracts from the 22nd International Symposium on Signal Transduction at the Blood–Brain Barriers
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0149-2
Correction to: A26 Cerebrospinal fluid outflow resistance is increased following small-moderate ischaemic stroke
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0144-7
Abstracts from Hydrocephalus 2019: The Eleventh Meeting of the International Society for Hydrocephalus and Cerebrospinal Fluid Disorders
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0156-3
Correction to: An isogenic neurovascular unit model comprised of human induced pluripotent stem cell-derived brain microvascular endothelial cells, pericytes, astrocytes, and neurons
来源期刊：Fluids and Barriers of the CNSDOI：10.1186/s12987-019-0151-8
