ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application.ASSAY and Drug Development Technologies coverage includes:-Assay design, target development, and high-throughput technologies-Hit to Lead optimization and medicinal chemistry through preclinical candidate selection-Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis-Approaches to assays configured for gene families, inherited, and infectious diseases-Assays and strategies for adapting model organisms to drug discovery-The use of stem cells as models of disease-Translation of phenotypic outputs to target identification-Exploration and mechanistic studies of the technical basis for assay and screening artifacts
分析和药物开发技术提供了新的技术和强大的工具，使早期筛选的关键进展。这项发表在杂志上的研究为药物的发现和开发提供了重要的治疗方法和平台。这本着名的同行评审期刊以原创论文为特色，以应用为导向的技术评论，关于新的和新兴的研究领域的主题问题，以及方法学和技术应用的报告。分析和药物开发技术覆盖范围包括：-分析设计，靶点开发和高通量技术-通过临床前候选人选择实现领先优化和药物化学-实验室自动化，样品管理，生物信息学，数据挖掘，虚拟筛选和数据分析-为基因家族，遗传和传染性疾病配置的分析方法-使模式生物适应药物发现的分析和策略-使用干细胞作为疾病模型-将表型输出转化为靶点识别-分析和筛选伪像的技术基础的探索和机制研究
Coadministration of Polypeptide-k and Curcumin Through Solid Self-Nanoemulsifying Drug Delivery System for Better Therapeutic Effect Against Diabetes Mellitus: Formulation, Optimization, Biopharmaceutical Characterization, and Pharmacodynamic Assessment.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.902
High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.896
High-Content and High-Throughput In Vivo Drug Screening Platforms Using Microfluidics.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.908
Axitinib-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles for Age-Related Macular Degeneration: Formulation Development and In Vitro Characterization.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.920
Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform
来源期刊：Assay and Drug Development TechnologiesDOI：10.1089/adt.2018.882
High-Content Screening Identifies New Inhibitors of Connexin 43 Gap Junctions.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.927
High-Throughput Zika Viral Titer Assay for Rapid Screening of Antiviral Drugs.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.881
The Role of Polyethylene Glycol Size in Chemical Spectra, Cytotoxicity, and Release of PEGylated Nanoliposomal Cisplatin.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.923
Repositioning of Itraconazole for the Management of Ocular Neovascularization Through Surface-Modified Nanostructured Lipid Carriers.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.898
Molecular Docking and In Silico Cogitation Validate Mefenamic Acid Prodrugs as Human Cyclooxygenase-2 Inhibitor.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.943
Macrophage Cytological Profiling and Anti-Inflammatory Drug Discovery.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.894
In Vitro Evaluation of Small Molecule Delivery into Articular Cartilage: Effect of Synovial Clearance and Compressive Load.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.907
Quantitative Size-Based Analysis of Tumor Spheroids and Responses to Therapeutics.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.895
Automated Machine Learning Diagnostic Support System as a Computational Biomarker for Detecting Drug-Induced Liver Injury Patterns in Whole Slide Liver Pathology Images.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.919
Human-Derived Brain Models: Windows Into Neuropsychiatric Disorders and Drug Therapies.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.922
Quality by Design-Based Crystallization of Curcumin Using Liquid Antisolvent Precipitation: Micromeritic, Biopharmaceutical, and Stability Aspects.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.913
Discovery of Natural Steroid 5 Alpha-Reductase Inhibitors.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.870
Systematically Prioritizing Candidates in Genome-Based Drug Repurposing
来源期刊：Assay and Drug Development TechnologiesDOI：10.1089/adt.2019.950
Fenugreek Leaf Extract and Its Gel Formulation Show Activity Against Malassezia furfur.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.918
Developing a High-Throughput Assay for the Integral Membrane Glycerol 3-Phosphate Acyltransferase.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.935
A Nonradioactive High-Throughput Screening-Compatible Cell-Based Assay to Identify Inhibitors of the Monocarboxylate Transporter Protein 1.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.936
Drug Repurposing Approach for Developing Novel Therapy Against Mupirocin-Resistant Staphylococcus aureus.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.944
Analysis and Quantification of Oxidized Low-Density Lipoprotein-Induced Lipid Droplets in Macrophages Through High-Content Screening: Application for Antiatherogenic Drugs Discovery.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.930
Technology for Discovery of Antifibrotic Drugs: Phenotypic Screening for LARP6 Inhibitors Using Inverted Yeast Three Hybrid System.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.904
Development of Nanoemulsion Preconcentrate of Capsanthin with Improved Chemical Stability.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.916
High-Throughput Three-Dimensional Hydrogel Cell Encapsulation Assay for Measuring Matrix Metalloproteinase Activity.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.877
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.942
Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.941
Protective and Modulatory Effects of Trapa bispinosa and Trigonella foenum-graecum on Neuroblastoma Cells Through Neuronal Nitric Oxide Synthase.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.912
In Silico Screening to Identify Inhibitors of Growth Factor Receptor 2–Focal Adhesion Kinase Interaction for Therapeutic Treatment of Pathological Cardiac Hypertrophy
来源期刊：Assay and Drug Development TechnologiesDOI：10.1089/ADT.2018.887
Neural Progenitor Cell Derivation Methodologies for Drug Discovery Applications.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.921
The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.914
Single-Molecule Characterization of Drug Delivery Systems.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.903
Possible Antidiabetic and Antioxidative Activity of Hydro-Methanolic Extract of Musa balbisiana (Colla) Flower in Streptozotocin-Induced Diabetic Male Albino Wistar Strain Rat: A Genomic Approach.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2018.889
Literature Search and Review.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.29087.lit
Assays to Interrogate the Ability of Compounds to Inhibit the AF-2 or AF-1 Transactivation Domains of the Androgen Receptor.
来源期刊：Assay and drug development technologiesDOI：10.1089/adt.2019.940
