ACS Synthetic Biology致力于发表合成生物学和生物系统的研究内容，包括综合、分子领域的高质量文章，促进人们对细胞、组织、器官机制和功能的认知。本期刊对新型遗传线路和基因产物的设计和合成研究特别感兴趣；同时也欢迎生物或生物杂交系统设计中的计算方法、以及合成生物学在各个领域的应用等。ACS Synthetic Biology is a monthly peer-reviewed journal dedicated to research across all areas of synthetic biology. The journal is particularly interested in studies on the design and synthesis of new biological or biohybrid systems; computational methods in the design of biological or biohybrid systems; and the application of synthetic biology in various areas.
该杂志特别感兴趣的是新的遗传电路和基因产物的设计和合成的研究;系统设计中的计算方法;以及理解疾病和代谢的综合应用方法。主题可能包括但不限于:遗传系统的设计和优化遗传电路设计及其将其组织为程序的原理计算方法以帮助遗传系统的设计量化遗传部分，电路和代谢通量的实验方法遗传零件库:它们的创建，分析和本体论表征蛋白质工程包括计算设计代谢工程和细胞制造，包括生物质转化天然产品的获取，工程和生产细胞编程的创新和创新应用医学应用，组织工程和治疗细胞的编程最小细胞设计和构造基因组学和基因组替代策略病毒工程合成生物的自动化和机器人组装平台dna合成方法宏基因组学和合成宏基因组分析生物信息学应用于基因发现，化学信息学，和途径构建基因优化方法用于转录和代谢组学的基因组规模测量系统生物学和方法集成多个数据来源体外和无细胞合成生物学和分子编程核酸工程。
Deconstructing Cell-Free Extract Preparation for in Vitro Activation of Transcriptional Genetic Circuitry.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00430
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00398
Engineering a Bifunctional Phr60-Rap60-Spo0A Quorum-Sensing Molecular Switch for Dynamic Fine-Tuning of Menaquinone-7 Synthesis in Bacillus subtilis.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00140
Opportunities at the Intersection of Synthetic Biology, Machine Learning, and Automation.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00540
Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00237
Engineering the S-Layer of Caulobacter crescentus as a Foundation for Stable, High-Density, 2D Living Materials.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00448
Model-assisted fine-tuning of central carbon metabolism in yeast through dCas9-based regulation.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00258
Machine Learning Applied to Predicting Microorganism Growth Temperatures and Enzyme Catalytic Optima.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00099
Pyruvate Carboxylase Variants Enabling Improved Lysine Production from Glucose Identified by Biosensor-Based High-Throughput Fluorescence-Activated Cell Sorting Screening.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00510
Biosynthesis and Heterologous Production of Argyrins.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00023
Pregnenolone overproduction in Yarrowia lipolytica by integrative components pairing of cytochrome P450scc system.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00018
3D Printing for the Fabrication of Biofilm-Based Functional Living Materials.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00192
Systematic evaluation of CRISPRa and CRISPRi modalities enables development of a multiplexed, orthogonal gene activation and repression system.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00527
Altering the Substrate Specificity of Acetyl-CoA Synthetase by Rational Mutagenesis of the Carboxylate Binding Pocket.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00008
An Expanded Synthetic Biology Toolkit for Gene Expression Control in Acetobacteraceae.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00168
Comparison of Integrases Identifies Bxb1-GA Mutant as the Most Efficient Site-Specific Integrase System in Mammalian Cells.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00089
Synthetic Biology Tools for the Fast-Growing Marine Bacterium Vibrio natriegens.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00176
Highly Efficient Single-Pot Scarless Golden Gate Assembly.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00480
Ligase-Mediated Threose Nucleic Acid Synthesis on DNA Templates.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00511
Reversible Gene Regulation in Mammalian Cells Using Riboswitch-Engineered Vesicular Stomatitis Virus Vector.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00177
Spatiotemporal Gene Repression System in the Heterocyst-Forming Multicellular Cyanobacterium Anabaena sp. PCC 7120.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00496
Point-of-Use Detection of Environmental Fluoride via a Cell-Free Riboswitch-Based Biosensor.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00347
Robust characterization of two distinct glutarate sensing transcription factors of Pseudomonas putida L-lysine metabolism.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00255
Building an Inducible T7 RNA Polymerase/T7 Promoter Circuit in Synechocystis sp. PCC6803.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00515
miRNA-Mediated Regulation of Synthetic Gene Circuits in the Green Alga Chlamydomonas reinhardtii.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00393
Systematic Evaluation of Genetic and Environmental Factors Affecting Performance of Translational Riboswitches
来源期刊：ACS Synthetic BiologyDOI：10.1021/acssynbio.9b00017
Driving the Scalability of DNA-Based Information Storage Systems.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00100
Saturation mutagenesis genome engineering of infective ΦX174 bacteriophage via unamplified oligo pools and golden gate assembly.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00411
Improved Efficiency of the Desulfurization of Oil Sulfur Compounds in Escherichia coli Using a Combination of Desensitization Engineering and DszC Overexpression.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00126
Optimization of Recombinant Membrane Protein Production in the Engineered Escherichia coli Strains SuptoxD and SuptoxR.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00120
Designing Spatially Distributed Gene Regulatory Networks To Elicit Contrasting Patterns
来源期刊：ACS Synthetic BiologyDOI：10.1021/acssynbio.8b00377
Combinatorial Sensor Design in Caulobacter crescentus for Selective Environmental Uranium Detection.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00484
Knock-Down of a ligIV Homologue Enables DNA Integration via Homologous Recombination in the Marine Diatom Phaeodactylum tricornutum.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00234
A broad-host-range CRISPRi toolkit for silencing gene expression in Burkholderia.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00232
Riboswitch Signal Amplification by Controlling Plasmid Copy Number.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00454
Biosynthetic Routes for Producing Various Fucosyl-Oligosaccharides.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00436
A Toolkit for Rapid Modular Construction of Biological Circuits in Mammalian Cells.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00322
CF-targeter: a rational biological cell factory targeting platform for biosynthetic target chemicals.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00070
Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi
来源期刊：ACS Synthetic BiologyDOI：10.1021/acssynbio.9b00106
Identification of Three Antimicrobials Activating Serotonin Receptor 4 in Colon Cells
来源期刊：ACS Synthetic BiologyDOI：10.1021/acssynbio.9b00310
Recombination-independent genome editing through CRISPR/Cas9-enhanced targetron delivery.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00293
Construction of Bacterial Cells with an Active Transport System for Unnatural Amino Acids.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00076
Synthetic Genetic Circuits for Self-Actuated Cellular Nanomaterial Fabrication Devices.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00235
Inducible Gene Switches with Memory in Human T Cells for Cellular Immunotherapy
来源期刊：ACS Synthetic BiologyDOI：10.1021/acssynbio.8b00512
Genetic selection for small molecule production in competitive microfluidic droplets.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00226
Microfluidic Synchronizer Using a Synthetic Nanoparticle-Capped Bacterium.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00058
Amelioration of diabetes in a murine model upon transplantation of pancreatic β-cells with optogenetic control of cyclic AMP.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00262
sboljs: Bringing the Synthetic Biology Open Language to the Web Browser.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.8b00338
Development of a highly sensitive whole-cell biosensor for arsenite detection through engineered promoter modifications.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00093
Construction of a Quadrangular Tetramer and a Cage-Like Hexamer from Three-Helix Bundle-Linked Fusion Proteins.
来源期刊：ACS synthetic biologyDOI：10.1021/acssynbio.9b00019
