Genome Biology covers all areas of biology and biomedicine studied from a genomic and post-genomic perspective. Content includes research, new methods and software tools, and reviews, opinions and commentaries. Areas covered include, but are not limited to: sequence analysis; bioinformatics; insights into molecular, cellular and organismal biology; functional genomics; epigenomics; population genomics; proteomics; comparative biology and evolution; systems and network biology; genome editing and engineering; genomics of disease; and clinical genomics.
基因组生物学涵盖了从基因组和后基因组角度研究的生物学和生物医学的所有领域。内容包括研究，新方法和软件工具，以及评论，意见和评论。涵盖的领域包括但不限于：序列分析;生物信息学;深入了解分子、细胞和有机体生物学;功能基因组学;表观基因组学;群体基因组学;蛋白质组学;比较生物学和进化论;系统与网络生物学;基因组编辑和工程;疾病基因组学;和临床基因组学。
Current status and applications of genome-scale metabolic models
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1730-3
Accuracy assessment of fusion transcript detection via read-mapping and de novo fusion transcript assembly-based methods
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1842-9
scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1906-x
Structural variant calling: the long and the short of it
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1828-7
Epigenetic modifications of histones in cancer
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1870-5
scPred: accurate supervised method for cell-type classification from single-cell RNA-seq data
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1862-5
Identifying significantly impacted pathways: a comprehensive review and assessment
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1790-4
Genomic analyses of an extensive collection of wild and cultivated accessions provide new insights into peach breeding history
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1648-9
Robust taxonomic classification of uncharted microbial sequences and bins with CAT and BAT
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1817-x
Single-cell transcriptomics unveils gene regulatory network plasticity
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1713-4
MetaCell: analysis of single-cell RNA-seq data using K-nn graph partitions
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1812-2
Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1637-z
The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1835-8
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1776-2
Bridging the gap between reference and real transcriptomes
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1710-7
DeepImpute: an accurate, fast, and scalable deep neural network method to impute single-cell RNA-seq data
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1837-6
Microbial genomes from non-human primate gut metagenomes expand the primate-associated bacterial tree of life with over 1000 novel species
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1923-9
AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1783-3
Modulating chromatin accessibility by transactivation and targeting proximal dsgRNAs enhances Cas9 editing efficiency in vivo
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1762-8
Reproducible biomedical benchmarking in the cloud: lessons from crowd-sourced data challenges
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1794-0
TOAST: improving reference-free cell composition estimation by cross-cell type differential analysis
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1778-0
eIF4A2 drives repression of translation at initiation by Ccr4-Not through purine-rich motifs in the 5′UTR
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1857-2
The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1890-1
Genomic signatures accompanying the dietary shift to phytophagy in polyphagan beetles
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1704-5
An enhanced genetic model of colorectal cancer progression history
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1782-4
Multiplexed promoterless gene expression with CRISPReader
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1712-5
MPRAnalyze: statistical framework for massively parallel reporter assays
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1787-z
Interactive roles of chromatin regulation and circadian clock function in plants
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1672-9
DNA extraction for human microbiome studies: the issue of standardization
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1843-8
PIRCh-seq: functional classification of non-coding RNAs associated with distinct histone modifications
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1880-3
Genomics and data science: an application within an umbrella
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1724-1
Correction to: Rapid turnover of life-cycle-related genes in the brown algae
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1657-8
The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1814-0
PGG.SNV: understanding the evolutionary and medical implications of human single nucleotide variations in diverse populations
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1838-5
Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1921-y
HOPS: automated detection and authentication of pathogen DNA in archaeological remains
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1903-0
The bio.tools registry of software tools and data resources for the life sciences
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1772-6
The inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1696-1
Modeling double strand break susceptibility to interrogate structural variation in cancer
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1635-1
Population dynamics of the human gut microbiome: change is the only constant
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1775-3
Genome-wide analysis of DNA replication timing in single cells: Yes! We’re all individuals
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1719-y
TransLiG: a de novo transcriptome assembler that uses line graph iteration
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1690-7
Correction to: MicroPro: using metagenomic unmapped reads to provide insights into human microbiota and disease associations
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1826-9
SEPATH: benchmarking the search for pathogens in human tissue whole genome sequence data leads to template pipelines
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1819-8
I-Boost: an integrative boosting approach for predicting survival time with multiple genomics platforms
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1640-4
Graph genomes article collection
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1636-0
Correction to: Epigenetic signatures associated with imprinted paternally expressed genes in the Arabidopsis endosperm
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1803-3
Correction to: RNA G-quadruplexes at upstream open reading frames cause DHX36- and DHX9-dependent translation of human mRNAs
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1737-9
Correction to: scBFA: modeling detection patterns to mitigate technical noise in large-scale single-cell genomics data
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1822-0
How to meet your ‘silent partner’: tips for approaching editors at conferences
来源期刊：Genome BiologyDOI：10.1186/s13059-019-1820-2
