Science Translational Medicine Mission: To promote human health by providing a forum for communication and cross-fertilization among basic, translational, and clinical research practitioners and trainees from all relevant established and emerging disciplines.Scope: Cardiovascular disease, immunology/vaccines, metabolism/diabetes/obesity, neuroscience/neurology/psychiatry, cancer, infectious diseases, policy, behavior, bioengineering, chemical genomics/drug discovery, imaging, applied physical sciences, medical nanotechnology, drug delivery, biomarkers, gene therapy/regenerative medicine, toxicology and pharmacokinetics, data mining, cell culture, animal and human studies, medical informatics, and other interdisciplinary approaches to medicine.
科学转化医学使命：通过为基础、转化和临床研究从业人员以及来自所有相关已建立和新兴学科的受训人员提供交流和相互促进的论坛，促进人类健康。心血管疾病、免疫学/疫苗、代谢/糖尿病/肥胖、神经科学/神经病学/精神病学、癌症、传染病、政策、行为、生物工程、化学基因组学/药物发现、成像、应用物理科学、医学纳米技术、药物递送、生物标记、基因治疗/再生医学、毒理学和药代动力学、数据挖掘、细胞培养、动物和人类研究、医学信息学、和其他跨学科的医学方法。
The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau5907
Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aao5253
Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau5758
Reproducing human and cross-species drug toxicities using a Liver-Chip
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax5516
Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw5680
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aav2685
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau3776
Challenges for mesenchymal stromal cell therapies
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aat2189
Sensitization to immune checkpoint blockade through activation of a STAT1/NK axis in the tumor microenvironment
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aav7816
Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau5266
Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau2086
Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aav0537
Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aar6659
Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aas9292
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau3174
Shaping of infant B cell receptor repertoires by environmental factors and infectious disease
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aat2004
Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aat9321
Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw7736
Clinical implications of tumor-intrinsic mechanisms regulating PD-L1
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aav4810
Estimating cholera incidence with cross-sectional serology
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau6242
TGF-β type 2 receptor–mediated modulation of the IL-36 family can be therapeutically targeted in osteoarthritis
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aan2585
Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau6039
Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau8866
DNA vaccination before conception protects Zika virus–exposed pregnant macaques against prolonged viremia and improves fetal outcomes
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay2736
A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aar3558
Sodium chloride is an ionic checkpoint for human TH2 cells and shapes the atopic skin microenvironment
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau0683
An antibody-drug conjugate directed to the ALK receptor demonstrates efficacy in preclinical models of neuroblastoma
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau9732
Enhancing safety of cytomegalovirus-based vaccine vectors by engaging host intrinsic immunity
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw2603
Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax9487
Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aau7411
Cognitive refractory state caused by spontaneous epileptic high-frequency oscillations in the human brain
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax7830
Twists and turns to translating 4-1BB cancer immunotherapy
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax4738
Yin Yang 1 protein ameliorates diabetic nephropathy pathology through transcriptional repression of TGFβ1
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw2050
A once-a-month oral contraceptive
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay2602
Antigenic competition in CD4+ T cell responses in a randomized, multicenter, double-blind clinical HIV vaccine trial
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw1673
The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aav4881
Neurogenesis takes a hit in Alzheimer’s disease
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax1726
Exacting Edward Jenner’s revenge: The quest for a new tuberculosis vaccine
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax4219
Doubling-down on prion protein function in Alzheimer’s disease
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay3567
Somatic mutations are improving their bad rap
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax4871
Comment on “An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness”
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aav4538
From mini-brains to neural networks
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay3570
A new player in hunger games
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay3569
p21: One protein to rule cell fate
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay3568
A randomized clinical efficacy study targeting mPGES1 or EP4 in dogs with spontaneous osteoarthritis
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw9993
A gut reaction to exercise
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaz9765
Squeezing inspiration from embryonic hearts
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw5317
A primate resource for autism research
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aay3571
A killer sidekick for antitumor T cells
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aaw5325
Demystifying anhedonia in childhood with large-scale networks
来源期刊：Science Translational MedicineDOI：10.1126/scitranslmed.aax1723
