The Annual Review of Pharmacology and Toxicology, in publication since 1961, covers the significant developments in the fields of pharmacology and toxicology, including receptors, transporters, enzymes, and chemical agents; drug development science; systems such as the immune system, central and autonomic nervous systems, gastrointestinal system, cardiovascular system, endocrine system, and pulmonary system; and special topics.
《药理学和毒理学年度回顾》自1961年出版以来，涵盖了药理学和毒理学领域的重大发展，包括受体、转运蛋白、酶和化学试剂;药物开发科学;系统如免疫系统、中枢和自主神经系统、胃肠系统、心血管系统、内分泌系统和肺系统;和专题。
Therapeutic Oligonucleotides: State of the Art.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021050
Environmental Obesogens: Mechanisms and Controversies.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021304
Modulating NRF2 in Disease: Timing Is Everything.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021856
The Exposome: Molecules to Populations.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021315
Pharmacologic Targeting of Hypoxia-Inducible Factors.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021637
Organoids for Drug Discovery and Personalized Medicine.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021108
Metals and Mechanisms of Carcinogenesis.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021031
Molecular Pharmacology and Neurobiology of Rapid-Acting Antidepressants.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010617-052811
Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021358
The Placebo Effect in Pain Therapies.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021542
The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021701
Lipid-Dependent Regulation of Ion Channels and G Protein-Coupled Receptors: Insights from Structures and Simulations.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023411
Therapeutic Approaches to the Treatment of Tinnitus.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021556
Emerging Pharmacological Targets for the Treatment of Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Type 2 Diabetes.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010716-104727
Novel Clinical Toxicology and Pharmacology of Organophosphorus Insecticide Self-Poisoning.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021842
Systems Pharmacology: Defining the Interactions of Drug Combinations.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021511
Beyond THC and Endocannabinoids.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021441
Muscle Wasting Diseases: Novel Targets and Treatments.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021041
Assessment of Pharmacokinetic Drug-Drug Interactions in Humans: In Vivo Probe Substrates for Drug Metabolism and Drug Transport Revisited.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021909
Big Data and Artificial Intelligence Modeling for Drug Discovery.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023324
Applications of Immunopharmacogenomics: Predicting, Preventing, and Understanding Immune-Mediated Adverse Drug Reactions.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021818
Challenges in Orphan Drug Development: Identification of Effective Therapy for Thyroid-Associated Ophthalmopathy.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010617-052509
Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023420
Proteasome Inhibitor Drugs.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023603
Recent Developments in Understanding Barrier Mechanisms in the Developing Brain: Drugs and Drug Transporters in Pregnancy, Susceptibility or Protection in the Fetal Brain?
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021430
Surviving in the Valley of Death: Opportunities and Challenges in Translating Academic Drug Discoveries.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021625
Targeting the Trafficking of Kidney Water Channels for Therapeutic Benefit.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023654
Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023309
Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023537
(Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023711
Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023703
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021807
Role of Cell Death in Toxicology: Does It Matter How Cells Die?
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021725
Structural Basis for Allosteric Modulation of Class B G Protein-Coupled Receptors.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023301
Moving from the Trial to the Real World: Improving Medication Adherence Using Insights of Implementation Science.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021348
β2 Adrenergic Receptor Complexes with the L-Type Ca2+ Channel CaV1.2 and AMPA-Type Glutamate Receptors: Paradigms for Pharmacological Targeting of Protein Interactions.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023404
Gene-Based Dose Optimization in Children.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023459
Artificial Intelligence in Drug Treatment.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023746
G Protein-Coupled Receptor Pharmacology at the Single-Molecule Level.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023348
Barriers to Ensuring Access to Affordable Prescription Drugs.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010919-023518
Drug Therapies for Chronic Cholestatic Liver Diseases.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021059
Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain.
来源期刊：Annual review of pharmacology and toxicologyDOI：10.1146/annurev-pharmtox-010818-021712
