Physical Biology publishes articles in the broad interdisciplinary field bridging biology with the physical sciences and engineering. This journal focuses on research in which quantitative approaches – experimental, theoretical and modeling – lead to new insights into biological systems at all scales of space and time, and all levels of organizational complexity.Physical Biology accepts contributions from a wide range of biological sub-fields, including topics such as:molecular biophysics, including single molecule studies, protein-protein and protein-DNA interactionssubcellular structures, organelle dynamics, membranes, protein assemblies, chromosome structureintracellular processes, e.g. cytoskeleton dynamics, cellular transport, cell divisionsystems biology, e.g. signaling, gene regulation and metabolic networkscells and their microenvironment, e.g. cell mechanics and motility, chemotaxis, extracellular matrix, biofilmscell-material interactions, e.g. biointerfaces, electrical stimulation and sensing, endocytosiscell-cell interactions, cell aggregates, organoids, tissues and organsdevelopmental dynamics, including pattern formation and morphogenesisphysical and evolutionary aspects of disease, e.g. cancer progression, amyloid formationneuronal systems, including information processing by networks, memory and learningpopulation dynamics, ecology, and evolutioncollective action and emergence of collective phenomena.
《物理生物学》在广泛的跨学科领域发表文章,将生物学与物理科学和工程学联系起来。物理生物学接受来自广泛生物学子领域的贡献,包括以下主题:分子生物物理学,包括单分子研究、蛋白质-蛋白质和蛋白质-DNA相互作用亚细胞结构、细胞器动力学、膜、蛋白质组装、染色体结构细胞内过程,如细胞骨架动力学、细胞转运、细胞分裂系统生物学,如信号传导、基因调控和代谢网络细胞及其微环境,如细胞力学和运动性、趋化性、胞外基质、生物膜细胞-材料相互作用,如生物界面、电刺激和传感、内吞细胞-细胞相互作用、细胞聚集体、类器官、组织和器官发育动力学,包括模式形成和形态发生疾病的物理和进化方面,如癌症进展、淀粉样蛋白形成神经元系统,包括网络信息处理、记忆和学习群体动力学、生态学和进化集体行动和集体现象的出现。
Intermediate cell states in epithelial-to-mesenchymal transition
来源期刊:Physical biologyDOI:10.1088/1478-3975/aaf928
Stability and mean residence times for hybrid epithelial/mesenchymal phenotype.
来源期刊:Physical biologyDOI:10.1088/1478-3975/aaf7b7
Testing the gene expression classification of the EMT spectrum.
来源期刊:Physical biologyDOI:10.1088/1478-3975/aaf8d4
Modelling cell-free RNA and protein synthesis with minimal systems.
来源期刊:Physical biologyDOI:10.1088/1478-3975/aaf33d
Towards control of cellular decision-making networks in the epithelial-to-mesenchymal transition.
来源期刊:Physical biologyDOI:10.1088/1478-3975/aaffa1
Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic intervention.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab157a
Quantitative imaging of gene-expressing liposomes reveals rare favorable phenotypes.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab0c62
A possible role for epigenetic feedback regulation in the dynamics of the Epithelial-Mesenchymal Transition (EMT).
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab34df
Fight against background noise in stimulated emission depletion nanoscopy.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab255c
Androgen receptor nuclear localization correlates with AR-V7 mRNA expression in circulating tumor cells (CTCs) from metastatic castration resistance prostate cancer patients.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab073a
Mapping spatio-temporal dynamics of single biomolecules in living cells.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab5167
DCA for genome-wide epistasis analysis: the statistical genetics perspective.
来源期刊:Physical biologyDOI:10.1088/1478-3975/aafbe0
Biomechanical regulation of EMT and epithelial morphogenesis in amniote epiblast.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab1048
The transmembrane protein fibrocystin/polyductin regulates cell mechanics and cell motility.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab39fa
Constraining the complexity of promoter dynamics using fluctuations in gene expression.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab4e57
Effects of spatial dimensionality and steric interactions on microtubule-motor self-organization
来源期刊:Physical BiologyDOI:10.1088/1478-3975/ab0fb1
Evaluating single-particle tracking by photo-activation localization microscopy (sptPALM) in Lactococcus lactis.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab0162
On the origin of the tensile strength of insect swarms.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab12b9
Landscape perspectives of tumor, EMT, and development.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2029
Power series method for solving TASEP-based models of mRNA translation.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab57a0
Misalignment between the magnetic dipole moment and the cell axis in the magnetotactic bacterium Magnetospirillum magneticum AMB-1.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2858
From molecules to multispecies ecosystems: the roles of structure in bacterial biofilms.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab1384
A simplified approach for the determination of fitting constants in Oliver - Pharr method regarding biological samples.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab252e
Phage therapy administered noninvasively could be effective in thin tubes subject to episodic flow despite washout: a simulation study
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2ea0
Statistical mechanical properties of sequence space determine the efficiency of the various algorithms to predict interaction energies and native contacts from protein coevolution.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab1c15
Multiparametric topological analysis of reconstructed rat brain arterial system.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2704
Tripartite cell networks for glucose homeostasis.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2a9d
Emergent membrane morphologies in relaxed and tense membranes in presence of reversible adhesive pinning interactions.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab48d5
Phase transitions in mutualistic communities under invasion.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab0946
The rise of bottom-up synthetic biology and cell-free biology.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab1bed
Decoding the grammar of transcriptional regulation from RNA polymerase measurements: models and their applications.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab45bf
Aggregation dynamics of active cells on non-adhesive substrate.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab1e76
Impulsive signaling model of cytoneme-based morphogen gradient formation.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2c5a
Growth-dependent drug susceptibility can prevent or enhance spatial expansion of a bacterial population.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab131e
Using Flow Cytometry and Multistage Machine Learning to Discover Label-Free Signatures of Algal Lipid Accumulation
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2c60
Symmetry considerations elucidate the roles of global shape and local interactions in the equilibrium fluctuations and cooperativity of protein assemblies.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab1051
A computational approach for detecting micro-domains and confinement domains in cells: a simulation study.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab5e1d
Microrheology of interphase chromosomes with spatial constraints: A computational study.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab39c1
Computation capacities of a broad class of signaling networks are higher than their communication capacities
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab4345
Pulling-force generation by ensembles of polymerizing actin filaments.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab59bd
Stochastic models of polymerization based axonal actin transport.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab29cd
Protrusion membrane pearling emerges during three-dimensional cell division.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab4549
Terasaki spiral ramps and intracellular diffusion.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab4080
Determining the binding parameters from co-sedimentation assays.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab2c82
Brownian-like deviation of neighboring cells in the early embryogenesis of the zebrafish.
来源期刊:Physical biologyDOI:10.1088/1478-3975/aaf92d
Cell migration driven by substrate deformation gradients.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab39c7
Diffusion analysis of single particle trajectories in a Bayesian nonparametrics framework.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab64b3
Finite element modelling of discontinuous action potential propagation in larval zebrafish and human cardiac tissue.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab4d62
Stochastic cell renewal process and lengthening of cell cycle.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab576c
Stochastic modeling of gene expression: application of ensembles of trajectories.
来源期刊:Physical biologyDOI:10.1088/1478-3975/ab3ea5