Pharmaceutical Research, an official journal of the American Association of Pharmaceutical Scientists, is committed to publishing novel research that is mechanism-based, hypothesis-driven and addresses significant issues in drug discovery, development and regulation. Current areas of interest include, but are not limited to:-(pre)formulation engineering and processing-computational biopharmaceutics-drug delivery and targeting-molecular biopharmaceutics and drug disposition (including cellular and molecular pharmacology)-pharmacokinetics, pharmacodynamics and pharmacogenetics.Research may involve nonclinical and clinical studies, and utilize both in vitro and in vivo approaches. Studies on small drug molecules, pharmaceutical solid materials (including biomaterials, polymers and nanoparticles) biotechnology products (including genes, peptides, proteins and vaccines), and genetically engineered cells are welcome.
《药学研究》是美国药学科学家协会的官方期刊，致力于发表以机制为基础、以假设为驱动、解决药物发现、开发和监管中重大问题的新颖研究。目前感兴趣的领域包括但不限于：-（预）制剂工程和加工-计算生物药剂学-药物递送和靶向-分子生物药剂学和药物处置（包括细胞和分子药理学）-药物动力学、药效学和药物遗传学。研究可能涉及非临床和临床研究，并利用体外和体内方法。欢迎开展药物小分子、药用固体材料（包括生物材料、聚合物和纳米颗粒）、生物技术产品（包括基因、多肽、蛋白质和疫苗）、基因工程细胞等方面的研究。
An Effective Technology for the Development of Immediate Release Solid Dosage Forms Containing Low-Dose Drug: Fused Deposition Modeling 3D Printing
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2655-y
Surface Modification of Polymeric Nanoparticles with M2pep Peptide for Drug Delivery to Tumor-Associated Macrophages
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2596-5
Sizing up the Next Generation of Nanomedicines
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2736-y
The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2629-0
Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2651-2
ApoE-2 Brain-Targeted Gene Therapy Through Transferrin and Penetratin Tagged Liposomal Nanoparticles
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2691-7
A Single Hydrogen to Fluorine Substitution Reverses the Trend of Surface Composition Enrichment of Sorafenib Amorphous Solid Dispersion upon Moisture Exposure
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2632-5
Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2665-9
A Multifunctional Hydrogel Delivers Gold Compound and Inhibits Human Lung Cancer Xenograft
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2581-z
Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2615-6
Why Wait? The Case for Treating Tuberculosis with Inhaled Drugs
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2704-6
Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2666-8
Multi-Solvent Microdroplet Evaporation: Modeling and Measurement of Spray-Drying Kinetics with Inhalable Pharmaceutics
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2630-7
Efficacy of Surface-Modified PLGA Nanoparticles as a Function of Cervical Cancer Type
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2602-y
Nanomedicines for Infectious Diseases
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2603-x
Heat Enhanced Follicular Delivery of Isotretinoin to the Skin
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2659-7
In vitro Pharmacokinetic Cell Culture System that Simulates Physiologic Drug and Nanoparticle Exposure to Macrophages
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2576-9
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2613-8
Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide Delivery
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2682-8
Formation of Protein Corona on Nanoparticle Affects Different Complement Activation Pathways Mediated by C1q
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2747-8
Functional and Nonclinical Similarity of ABP 980, a Biosimilar of Trastuzumab
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2702-8
Polyelectrolyte Carboxymethyl Cellulose for Enhanced Delivery of Doxorubicin in MCF7 Breast Cancer Cells: Toxicological Evaluations in Mice Model
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2598-3
Utilization of In Vitro, In Vivo and In Silico Tools to Evaluate the pH-Dependent Absorption of a BCS Class II Compound and Identify a pH-Effect Mitigating Strategy
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2698-0
E-Jet 3D-Printed Scaffolds as Sustained Multi-Drug Delivery Vehicles in Breast Cancer Therapy
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2687-3
Octreotide Nanoparticles Showed Affinity for In Vivo MIA Paca-2 Inducted Pancreas Ductal Adenocarcinoma Mimicking Pancreatic Polypeptide-Secreting Tumor of the Distal Pancreas (PPoma)
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2678-4
Mucins are Involved in the Intestinal Permeation of Lipophilic Drugs in the Proximal Region of Rat Small Intestine
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2701-9
Surface Composition and Formulation Heterogeneity of Protein Solids Produced by Spray Drying
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2738-9
Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2586-7
How Full-Length FVIII Benefits from Its Heterogeneity – Insights into the Role of the B-Domain
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2599-2
A Comprehensive Preclinical Evaluation of Intravenous Etoposide Lipid Emulsion
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2637-0
A Sialylated-Bortezomib Prodrug Strategy Based on a Highly Expressed Selectin Target for the Treatment of Leukemia or Solid Tumors
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2714-4
Challenging the CNS Targeting Potential of Systemically Administered Nanoemulsion Delivery Systems: a Case Study with Rapamycin-Containing Fish Oil Nanoemulsions in Mice
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2667-7
Minimum Interfacial Bonding Strength for Bilayer Tablets Determined Using a Survival Test
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2675-7
Proton Oriented-“Smart Depot” for Responsive Release of Ca2+ to Inhibit Peptide Acylation in PLGA Microspheres
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2640-5
Challenges and Opportunities for Patient Centric Drug Product Design: Industry Perspectives
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2616-5
Mathematical Modeling and Simulation to Investigate the CNS Transport Characteristics of Nanoemulsion-Based Drug Delivery Following Intranasal Administration
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2610-y
Ophthalmic Drug Discovery and Development: Regulatory Aspects of Patient Focused Drug Development in Ophthalmology
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2577-8
A Flow Cytometric Method to Quantify the Endosomal Escape of a Protein Toxin to the Cytosol of Target Cells
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2725-1
Differentiating the Effects of Oxidative Stress Tests on Biopharmaceuticals
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2627-2
On-Demand Manufacturing of Direct Compressible Tablets: Can Formulation Be Simplified?
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2716-2
Thrifty, Rapid Intestinal Monolayers (TRIM) Using Caco-2 Epithelial Cells for Oral Drug Delivery Experiments
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2712-6
Editorial to Theme Issue on Cell Based Therapeutics
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2573-z
The Duration of Nerve Block from Local Anesthetic Formulations in Male and Female Rats
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2715-3
Does Older Age Lead to Higher Risk for Neutropenia in Patients Treated with Paclitaxel?
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2697-1
Correction to: Evaluation of Wound Healing Potential of β-Chitin Hydrogel/Nano Zinc Oxide Composite Bandage
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2623-6
Correction to: Multi-Solvent Microdroplet Evaporation: Modeling and Measurement of Spray-Drying Kinetics with Inhalable Pharmaceutics
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2648-x
Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2706-4
Application of Magnetic Resonance to Assess Lyophilized Drug Product Reconstitution
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2591-x
Pharmacokinetic and Pharmacodynamic Properties of a Micro-Dose Nasal Spray Formulation of Desmopressin (AV002) in Healthy Water-Loaded Subjects
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2628-1
Correction to: Pharmacokinetic and Tissue Distribution Profile of Long Acting Tenofovir Alafenamide and Elvitegravir Loaded Nanoparticles in Humanized Mice Model
来源期刊：Pharmaceutical ResearchDOI：10.1007/s11095-019-2638-z
