Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research. We propagate work that challenges standard conjecture and builds on previous studies, in particular those that lead to establishing new paradigms in the etio-pathogenesis, diagnosis, treatment, or prevention of cancers, and in processes that drive metastatic spread, and provide important insights into cancer biology beyond what has been revealed thus far.
Oncogene的目标是通过发表杰出的研究成果，在我们对导致癌症的过程的知识方面取得实质性进展。我们推广挑战标准猜想的工作，并建立在以前的研究基础上，特别是那些导致建立新的模式，在病因-发病机制，诊断，治疗，或预防癌症，在过程中，推动转移扩散，并提供重要的见解，癌症生物学超出了迄今为止所揭示的。
The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment
来源期刊：OncogeneDOI：10.1038/s41388-019-0684-y
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma
来源期刊：OncogeneDOI：10.1038/s41388-018-0657-6
Cancer extracellular vesicles contribute to stromal heterogeneity by inducing chemokines in cancer-associated fibroblasts
来源期刊：OncogeneDOI：10.1038/s41388-019-0832-4
Pan-cancer analysis of clinical relevance of alternative splicing events in 31 human cancers
来源期刊：OncogeneDOI：10.1038/s41388-019-0910-7
Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab
来源期刊：OncogeneDOI：10.1038/s41388-019-0675-z
BRAFV600E-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts
来源期刊：OncogeneDOI：10.1038/s41388-019-0919-y
MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-0760-3
Neurotransmitters: emerging targets in cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1006-0
Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells
来源期刊：OncogeneDOI：10.1038/s41388-019-0890-7
Dissecting mechanisms of resistance to targeted drug combination therapy in human colorectal cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-0780-z
Inducible formation of leader cells driven by CD44 switching gives rise to collective invasion and metastases in luminal breast carcinomas
来源期刊：OncogeneDOI：10.1038/s41388-019-0899-y
Cancer-induced inflammation and inflammation-induced cancer in colon: a role for S1P lyase
来源期刊：OncogeneDOI：10.1038/s41388-019-0758-x
MHC class I dysfunction of glioma stem cells escapes from CTL-mediated immune response via activation of Wnt/β-catenin signaling pathway
来源期刊：OncogeneDOI：10.1038/s41388-019-1045-6
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation
来源期刊：OncogeneDOI：10.1038/s41388-019-0798-2
Interferon-stimulated gene 15 modulates cell migration by interacting with Rac1 and contributes to lymph node metastasis of oral squamous cell carcinoma cells
来源期刊：OncogeneDOI：10.1038/s41388-019-0731-8
Precision medicine by designer interference peptides: applications in oncology and molecular therapeutics
来源期刊：OncogeneDOI：10.1038/s41388-019-1056-3
An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells
来源期刊：OncogeneDOI：10.1038/s41388-019-0729-2
Chemotherapy impacts on the cellular response to CDK4/6 inhibition: distinct mechanisms of interaction and efficacy in models of pancreatic cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1102-1
Midkine (MDK) growth factor: a key player in cancer progression and a promising therapeutic target
来源期刊：OncogeneDOI：10.1038/s41388-019-1124-8
Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
来源期刊：OncogeneDOI：10.1038/s41388-019-1047-4
A drug library screen identifies Carbenoxolone as novel FOXO inhibitor that overcomes FOXO3-mediated chemoprotection in high-stage neuroblastoma
来源期刊：OncogeneDOI：10.1038/s41388-019-1044-7
HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1065-2
RNA-binding Motif Protein 10 Induces Apoptosis and Suppresses Proliferation by Activating p53
来源期刊：OncogeneDOI：10.1038/s41388-019-1034-9
Hepatoma-derived growth factor participates in Helicobacter Pylori-induced neutrophils recruitment, gastritis and gastric carcinogenesis
来源期刊：OncogeneDOI：10.1038/s41388-019-0886-3
Cellular prion protein transcriptionally regulated by NFIL3 enhances lung cancer cell lamellipodium formation and migration through JNK signaling
来源期刊：OncogeneDOI：10.1038/s41388-019-0994-0
Oncogenic HOXB8 is driven by MYC-regulated super-enhancer and potentiates colorectal cancer invasiveness via BACH1
来源期刊：OncogeneDOI：10.1038/s41388-019-1013-1
Invasion and metastasis: the elusive hallmark of cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1110-1
Signal transducer and activator of transcription (STAT)-5: an opportunity for drug development in oncohematology
来源期刊：OncogeneDOI：10.1038/s41388-019-0752-3
Centrosome loss results in an unstable genome and malignant prostate tumors
来源期刊：OncogeneDOI：10.1038/s41388-019-0995-z
PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells
来源期刊：OncogeneDOI：10.1038/s41388-019-1064-3
Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model
来源期刊：OncogeneDOI：10.1038/s41388-019-0880-9
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm
来源期刊：OncogeneDOI：10.1038/s41388-019-0895-2
Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F
来源期刊：OncogeneDOI：10.1038/s41388-019-1009-x
Proteomic analysis reveals a role for PAX8 in peritoneal colonization of high grade serous ovarian cancer that can be targeted with micelle encapsulated thiostrepton
来源期刊：OncogeneDOI：10.1038/s41388-019-0842-2
Metabolic targeting of HIF-1α potentiates the therapeutic efficacy of oxaliplatin in colorectal cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-0999-8
A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism
来源期刊：OncogeneDOI：10.1038/s41388-019-1051-8
EZH2 targeting in medulloblastoma reduces tumor growth through epigenetic reactivation of the BAI1/p53 tumor suppressor pathway
来源期刊：OncogeneDOI：10.1038/s41388-019-1036-7
Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases
来源期刊：OncogeneDOI：10.1038/s41388-019-0850-2
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1060-7
SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis
来源期刊：OncogeneDOI：10.1038/s41388-019-1041-x
A novel conditional NPM-ALK-driven model of CD30+ T-cell lymphoma mediated by a translational stop cassette
来源期刊：OncogeneDOI：10.1038/s41388-019-1058-1
BMP10 suppresses hepatocellular carcinoma progression via PTPRS–STAT3 axis
来源期刊：OncogeneDOI：10.1038/s41388-019-0943-y
Correction: USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation
来源期刊：OncogeneDOI：10.1038/s41388-019-0831-5
Comparison of the different mechanisms of cytotoxicity induced by Checkpoint Kinase I inhibitors when used as single agents or in combination with DNA damage
来源期刊：OncogeneDOI：10.1038/s41388-019-1079-9
Abstracts from the 2nd International Norges Teknisk-Naturvitenskapelige Universitet (NTNU) Symposium: Day 2—biomarkers in precision diagnosis and treatment
来源期刊：OncogeneDOI：10.1038/s41388-019-1048-3
Correction: Primary tumor-derived exosomes facilitate metastasis by regulating adhesion of circulating tumor cells via SMAD3 in liver cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-0830-6
Correction: The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor
来源期刊：OncogeneDOI：10.1038/s41388-019-0874-7
TFAP2C regulates carbonic anhydrase XII in human breast cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1062-5
Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-0835-1
Correction: Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancer
来源期刊：OncogeneDOI：10.1038/s41388-019-1049-2
