Nucleic Acids Research (NAR) publishes the results of leading edge research into physical, chemical, biochemical and biological aspects of nucleic acids and proteins involved in nucleic acid metabolism and/or interactions. It enables the rapid publication of papers under the following categories: Chemistry and synthetic biology; Computational biology; Gene regulation, chromatin and epigenetics; Genome integrity, repair and replication; Genomics; Molecular biology; Nucleic acid enzymes; RNA and Structural biology. A Survey and Summary section provides a format for brief reviews. The first issue of each year is devoted to biological databases, and an issue in July is devoted to papers describing web-based software resources of value to the biological community.NAR Methods Online provides a forum for the online publication of methods papers.
核酸研究(NAR)发布了涉及核酸代谢和/或相互作用的核酸和蛋白质的物理,化学,生化和生物学方面的前沿研究结果。它可以快速发表以下类别的论文:化学和合成生物学;计算生物学;基因调控,染色质和表观遗传学;基因组完整性,修复和复制;基因组学;分子生物学;核酸酶; RNA和结构生物学。调查和摘要部分提供了简要审查的格式。每年的第一期致力于生物数据库,7月的一期致力于描述对生物社区有价值的基于web的软件资源的论文。NAR方法在线为在线发布方法论文提供了一个论坛。
SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz382
Single-molecule imaging of DNA gyrase activity in living Escherichia coli
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gky1143
AnnoTree: visualization and exploration of a functionally annotated microbial tree of life
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz246
The International Genome Sample Resource (IGSR) collection of open human genomic variation resources
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz836
Updated MS²PIP web server delivers fast and accurate MS² peak intensity prediction for multiple fragmentation methods, instruments and labeling techniques
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz299
CancerSplicingQTL: a database for genome-wide identification of splicing QTLs in human cancer
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gky954
Next-level riboswitch development—implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz216
TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gky1019
PhaSepDB: a database of liquid–liquid phase separation related proteins
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz847
LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz655
DeepRibo: a neural network for precise gene annotation of prokaryotes by combining ribosome profiling signal and binding site patterns
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz061
miRPathDB 2.0: a novel release of the miRNA Pathway Dictionary Database
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz1022
Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz833
Cell-type-specific analysis of alternative polyadenylation using single-cell transcriptomics data
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz781
snoDB: an interactive database of human snoRNA sequences, abundance and interactions
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz884
INGA 2.0: improving protein function prediction for the dark proteome
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz375
DREAM and RB cooperate to induce gene repression and cell-cycle arrest in response to p53 activation
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz635
Data-driven characterization of molecular phenotypes across heterogeneous sample collections
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz281
Nucleotide excision repair of abasic DNA lesions
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz558
Long-read amplicon denoising
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz657
Exploring the effects of cosolutes and crowding on the volumetric and kinetic profile of the conformational dynamics of a poly dA loop DNA hairpin: a single-molecule FRET study
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gky1122
Thera-SAbDab: the Therapeutic Structural Antibody Database
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz827
Maturation of atypical ribosomal RNA precursors in Helicobacter pylori
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz258
Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz472
WITER: a powerful method for estimation of cancer-driver genes using a weighted iterative regression modelling background mutation counts
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz566
Conformational communication mediates the reset step in t6A biosynthesis
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz439
Determining the effects of DNA sequence on Hel308 helicase translocation along single-stranded DNA using nanopore tweezers
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz004
Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz542
MutationDistiller: user-driven identification of pathogenic DNA variants
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz330
Regulation of Rep helicase unwinding by an auto-inhibitory subdomain
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz023
Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz164
A kinetochore-based ATM/ATR-independent DNA damage checkpoint maintains genomic integrity in trypanosomes
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz476
Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz903
DNA replication initiation in Bacillus subtilis: structural and functional characterization of the essential DnaA–DnaD interaction
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gky1220
Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz725
OHNOLOGS v2: a comprehensive resource for the genes retained from whole genome duplication in vertebrates
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz909
PRECOG: PREdicting COupling probabilities of G-protein coupled receptors
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz392
Genome replication dynamics of a bacteriophage and its satellite reveal strategies for parasitism and viral restriction
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz1005
Pattern preferences of DNA nucleotide motifs by polyamines putrescine2+, spermidine3+ and spermine4+
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz434
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz1006
Transcriptional and post-transcriptional events trigger de novo infB expression in cold stressed Escherichia coli
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz187
Structure-guided post-SELEX optimization of an ochratoxin A aptamer
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz336
Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz143
HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz1129
A multi-axial RNA joint with a large range of motion promotes sampling of an active ribozyme conformation
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz098
RbfA and IF3 couple ribosome biogenesis and translation initiation to increase stress tolerance
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz1065
Phosphorylation orchestrates the structural ensemble of the intrinsically disordered protein HMGA1a and modulates its DNA binding to the NFκB promoter
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz614
A 5′ fragment of Xist can sequester RNA produced from adjacent genes on chromatin
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz432
High resolution discovery of chromatin interactions
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz051
Histone H4 H75E mutation attenuates global genomic and Rad26-independent transcription-coupled nucleotide excision repair
来源期刊:Nucleic Acids ResearchDOI:10.1093/nar/gkz453