Nature Chemical Biology is an international monthly journal that provides a high-visibility forum for the publication of top-tier original research and commentary for the chemical biology community. Chemical biology combines the scientific ideas and approaches of chemistry, biology and allied disciplines to understand and manipulate biological systems with molecular precision. The journal publishes papers from the expanding community of chemical biologists, including contributions from chemists who are applying the principles and tools of chemistry to biological questions and from biologists who are interested in understanding and controlling biological processes at the molecular level.
《自然化学生物学》是一份国际性月刊，为化学生物学界提供了一个高知名度的论坛，发表顶级原创研究和评论。化学生物学结合了化学、生物学和相关学科的科学思想和方法，以分子精度理解和操纵生物系统。该杂志发表来自不断扩大的化学生物学家社区的论文，包括将化学原理和工具应用于生物学问题的化学家和对在分子水平上理解和控制生物过程感兴趣的生物学家的贡献。
Pharmacological targeting of the unfolded protein response for disease intervention
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0326-2
MCC950 closes the active conformation of NLRP3 to an inactive state
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0278-6
S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0323-5
Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0304-8
Automated structure prediction of trans-acyltransferase polyketide synthase products
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0313-7
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0263-0
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0411-6
Engineering of an oleaginous bacterium for the production of fatty acids and fuels
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0295-5
De-Novo-Designed Translation-Repressing Riboregulators for Multi-Input Cellular Logic
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0388-1
A dimerization-based fluorogenic dye-aptamer module for RNA imaging in live cells
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0381-8
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0227-4
Accurate annotation of human protein-coding small open reading frames
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0425-0
A family of radical halogenases for the engineering of amino-acid-based products
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0355-x
Sequential assembly of the septal cell envelope prior to V snapping in Corynebacterium glutamicum
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-018-0206-1
Near-equilibrium glycolysis supports metabolic homeostasis and energy yield
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0364-9
Glycan sulfation patterns define autophagy flux at axon tip via PTPRσ-cortactin axis
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0274-x
Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0386-3
A ligand gated strand displacement mechanism for ZTP riboswitch transcription control
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0382-7
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0370-y
Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-018-0205-2
A programmable DNA-origami platform for studying lipid transfer between bilayers
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0325-3
Versatile biomanufacturing through stimulus-responsive cell–material feedback
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0357-8
Discovery of a first-in-class EZH2 selective degrader
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0421-4
Structural basis of a small molecule targeting RNA for a specific splicing correction
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0384-5
A basic motif anchoring ISWI to nucleosome acidic patch regulates nucleosome spacing
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0413-4
Pass-back chain extension expands multi-modular assembly line biosynthesis
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0385-4
Side-chain determinants of biopolymer function during selection and replication
来源期刊：Nature chemical biologyDOI：10.1038/s41589-019-0229-2
A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0365-8
Axonal iron transport in the brain modulates anxiety-related behaviors
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0371-x
Molecular basis for interactions between an acyl carrier protein and a ketosynthase
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0301-y
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0424-1
Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0380-9
Complete reconstitution of the diverse pathways of gentamicin B biosynthesis.
来源期刊：Nature Chemical BiologyDOI：10.2210/PDB5Z83/PDB
Dynamics of transcription–translation coordination tune bacterial indole signaling
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0430-3
Stick it to E3s
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0312-8
A newborn RNA switches its fate
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0391-6
Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0329-z
Extracellular phosphorylation in axon pathfinding
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0383-6
HIV seals an envelope
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0238-1
Publisher Correction: PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0255-0
Disorder guides order
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0398-z
An inside job
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0395-2
Understanding the language of drugged plants
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0389-0
Poked to death
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0397-0
Breaking up is hard to do
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0351-1
Cannabinoids on the rise
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0280-z
Processing for destruction
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0428-x
A super-powered S-layer
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0236-3
T(oo)bAd
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0347-x
Snappy cell division in Actinobacteria
来源期刊：Nature Chemical BiologyDOI：10.1038/s41589-019-0226-5
