Molecular Pharmacology publishes findings derived from the application of innovative structural biology, biochemistry, biophysics, physiology, genetics, and molecular biology to basic pharmacological problems that provide mechanistic insights that are broadly important for the fields of pharmacology and toxicology. Relevant topics include:Molecular Signaling / Mechanism of Drug ActionChemical Biology / Drug DiscoveryStructure of Drug-Receptor ComplexSystems Analysis of Drug ActionDrug Transport / Metabolism
《分子药理学》发表的研究成果来自于创新的结构生物学、生物化学、生物物理学、生理学、遗传学和分子生物学在基本药理学问题上的应用，这些研究提供了对药理学和毒理学领域具有广泛重要性的机制见解。相关主题包括：分子信号/药物作用机制化学生物学/药物发现药物-受体复合物的结构药物作用系统分析药物转运/代谢
A Biased View of μ-Opioid Receptors?
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.115956
Cannabinoid CB2 Agonist AM1710 Differentially Suppresses Distinct Pathological Pain States and Attenuates Morphine Tolerance and Withdrawal
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.113233
Context-Dependent Signaling of CXC Chemokine Receptor 4 and Atypical Chemokine Receptor 3
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115477
Human GPRC6A Mediates Testosterone-Induced Mitogen-Activated Protein Kinases and mTORC1 Signaling in Prostate Cancer Cells
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115014
Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114256
CXCR4/ACKR3 Phosphorylation and Recruitment of Interacting Proteins: Key Mechanisms Regulating Their Functional Status
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115360
Analysis of GABAA Receptor Activation by Combinations of Agonists Acting at the Same or Distinct Binding Sites
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.113464
Inhibition of the Warm Temperature–Activated Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116962
Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116616
Steady-State Activation and Modulation of the Concatemeric α1β2γ2L GABAA Receptor
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116913
Rationale for Using Irreversible Epidermal Growth Factor Receptor Inhibitors in Combination with Phosphatidylinositol 3-Kinase Inhibitors for Advanced Head and Neck Squamous Cell Carcinoma
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115162
A Mechanism-Based Approach to P2X7 Receptor Action
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115022
The L46P Mutant Confers a Novel Allosteric Mechanism of Resistance Toward the Influenza A Virus M2 S31N Proton Channel Blockers
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116640
Arylamine N-Acetyltransferase 1 Regulates Expression of Matrix Metalloproteinase 9 in Breast Cancer Cells: Role of Hypoxia-Inducible Factor 1-α
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.117432
CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116855
Calcium-Sensing Receptor Internalization Is β-Arrestin–Dependent and Modulated by Allosteric Ligands
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116772
Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.117259
Preferred Formation of Heteromeric Channels between Coexpressed SK1 and IKCa Channel Subunits Provides a Unique Pharmacological Profile of Ca2+-Activated Potassium Channels
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115634
A Small-Molecule Compound Selectively Activates K2P Channel TASK-3 by Acting at Two Distant Clusters of Residues
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115303
Understanding Peptide Binding in Class A G Protein-Coupled Receptors
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.115915
Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114066
Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin-Induced CYP3A4 and MDR1 Gene Expression
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114587
Development of a Photoswitchable Lithium-Sensitive Probe to Analyze Nonselective Cation Channel Activity in Migrating Cancer Cells
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115428
Thyrotropin Receptor: Allosteric Modulators Illuminate Intramolecular Signaling Mechanisms at the Interface of Ecto- and Transmembrane Domain
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116947
Ligand-Free Estrogen Receptor α (ESR1) as Master Regulator for the Expression of CYP3A4 and Other Cytochrome P450 Enzymes in the Human Liver
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116897
Nonclassical Ligand-Independent Regulation of Go Protein by an Orphan Class C G-Protein–Coupled Receptor
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.113019
Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114363
Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115386
TRESK (K2P18.1) Background Potassium Channel Is Activated by Novel-Type Protein Kinase C via Dephosphorylation
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116269
An Unexpected Role of Cholesterol Sulfotransferase and its Regulation in Sensitizing Mice to Acetaminophen-Induced Liver Injury
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114819
Modulation of Burst Firing of Neurons in Nucleus Reticularis of the Thalamus by GluN2C-Containing NMDA Receptors
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116780
Coordinated Transcriptional Regulation of Cytochrome P450 3As by Nuclear Transcription Factor Y and Specificity Protein 1
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114439
T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116319
Dantrolene Requires Mg2+ and ATP To Inhibit the Ryanodine Receptor
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116475
Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115196
Impact of Phosphodiesterase 4 Inhibition on the Operational Efficacy, Response Maxima, and Kinetics of Indacaterol-Induced Gene Expression Changes in BEAS-2B Airway Epithelial Cells: A Global Transcriptomic Analysis
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115311
CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.117333
Loss-of-Function Mutations in Human Regulator of G Protein Signaling RGS2 Differentially Regulate Pharmacological Reactivity of Resistance Vasculature
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116822
Conformational Changes in the 5-HT3A Receptor Extracellular Domain Measured by Voltage-Clamp Fluorometry
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116657
Selective Inhibition of Spindle Microtubules by a Tubulin-Binding Quinazoline Derivative
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116624
Activity of Adenylyl Cyclase Type 6 Is Suppressed by Direct Binding of the Cytoskeletal Protein 4.1G
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116426
Characterization and optimization of the novel TRPM2 antagonist tatM2NX.
来源期刊：Molecular pharmacologyDOI：10.1124/mol.119.117549
Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116483
Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.113647
Differential Regulation of Human Ether-à-Go-Go–Related Gene (hERG) Current and Expression by Activation of Protein Kinase C
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.115188
Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116871
Notice of Withdrawal
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.113407withdrawal
Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2
来源期刊：Molecular PharmacologyDOI：10.1124/mol.119.116798
Re: Dasmahapatra G, Almenara JA, and Grant S, “Flavopiridol and Histone Deacetylase Inhibitors Promote Mitochondrial Injury and Cell Death in Human Leukemia Cells that Overexpress Bcl-2.” Mol Pharmacol January 2006 69:288–298; doi:10.1124/mol.105.016154
来源期刊：Molecular PharmacologyDOI：10.1124/mol.105.016154retraction
Chronic Menthol Does Not Change Stoichiometry or Functional Plasma Membrane Levels of Mouse α3β4-Containing Nicotinic Acetylcholine Receptors
来源期刊：Molecular PharmacologyDOI：10.1124/mol.118.114769
