Molecular Pharmaceutics收录从分子机理来理解药物输送和药物输送系统的原创性研究成果。包括小分子、成像剂、蛋白质、肽、疫苗、基于细胞和基因的疗法，以及它们的表征，配方和递送。Molecular Pharmaceutics publishes original research that contributes significantly to the molecular mechanistic understanding of drug delivery and drug delivery systems. Modalities of interest include small molecules, imaging agents, proteins, peptides, vaccines, cell and gene-based therapies, and their characterization, formulation, and delivery. Scientific areas within the scope of the journal include:Modelling and simulation to aid mechanistic insights into drug deliveryMolecular understanding of formulationsFormulation performance under physiological conditionsMaterials science as it relates to drug, excipients and drug delivery system efficacy.Emerging techniques and technologies for drug delivery including theranostics, precision medicine and artificial intelligenceTheoretical and experimental peer-reviewed full-length research papers, critical reviews, perspectives, and communications are welcomed. Submission of a manuscript to Molecular Pharmaceutics implies that the same work has not been previously published, including as part of a public electronic database (preprint servers like bioRxiv and ChemRxiv are permissible), and is not under consideration for publication elsewhere. In addition, there must be no legal restrictions to publication, e.g., patent activities, at the time of submission.
《分子药剂学》发表的原创研究结果对药物输送和药物输送系统的分子机理理解有重要贡献。该杂志鼓励在药物发现和药物开发的界面上描述研究的贡献。该杂志范围内的科学领域包括物理和药物化学，生物化学和生物物理学，分子和细胞生物学，以及聚合物和材料科学，因为它们与药物和药物输送系统的功效有关。关于调节药物或药物产品的活性和功效的机制药物递送和药物靶向研究属于分子药剂学的范围。欢迎理论和实验同行评审的研究文章、交流、评论和观点。
Gold Nanoparticles in Cancer Treatment.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00810
Selective Cytotoxicity to HER2 Positive Breast Cancer Cells by Saporin-Loaded Nanobody-Targeted Polymeric Nanoparticles in Combination with Photochemical Internalization
来源期刊：Molecular PharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01318
Lipolysis-Permeation Setup for Simultaneous Study of Digestion and Absorption in Vitro
来源期刊：Molecular PharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00811
Cell Permeable NBD Peptide-Modified Liposomes by Hyaluronic Acid Coating for the Synergistic Targeted Therapy of Metastatic Inflammatory Breast Cancer.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01123
Synthesis of CSK-DEX-PLGA Nanoparticles for the Oral Delivery of Exenatide to Improve Its Mucus Penetration and Intestinal Absorption.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00809
Novel Hydrogel-Forming Microneedle Array for Intradermal Vaccination in Mice Using Ovalbumin as a Model Protein Antigen.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00895
An Integrated Transfer Learning and Multitask Learning Approach for Pharmacokinetic Parameter Prediction
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00816
Nanoparticle-Induced Controlled Drug Delivery Using Chitosan-Based Hydrogel and Scaffold: Application to Bone Regeneration.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00995
Radioiodinated Portable Albumin Binder as a Versatile Agent for in Vivo Imaging with Single-Photon Emission Computed Tomography.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01116
Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a Design of Experiment Approach
来源期刊：Molecular PharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00159
Rational design of PLGA nanoparticles vaccine delivery systems to improve immune responses.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00860
Sulfonamide-Derived Four-Component Molecular Hybrids as Novel DNA-Targeting Membrane Active Potentiators against Clinical Escherichia coli.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01021
In vitro and in vivo behavior of liposomes decorated with PEGs with different chemical features.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00887
Synthesis and Aggregation of a Porphyrin-Cored Hyperbranched Polyglycidol and Its Application as a Macromolecular Photosensitizer for Photodynamic Therapy.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01119
Near-Infrared Fluorescent Peptides with High Tumor Selectivity: Novel Probes for Image-Guided Surgical Resection of Orthotopic Glioma.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00888
Multifunctional Nanocomposites Based on Liposomes and Layered Double Hydroxides Conjugated with Glycylsarcosine for Efficient Topical Drug Delivery to the Posterior Segment of the Eye.
来源期刊：Molecular pharmaceuticsDOI：10.1021/ACS.MOLPHARMACEUT.8B01136
Mechanism of Supersaturation Suppression in Dissolution Process of Acidic Drug Salt.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00006
Host-Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2-Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01212
Paclitaxel-Loaded Folate-Coated pH-Sensitive Liposomes Enhance Cellular Uptake and Antitumor Activity.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00329
Nanoconfinement Effects on the Glass Transition and Crystallization Behaviors of Nifedipine.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01172
In Situ Characterization of the Microstructural Evolution of Biopharmaceutical Solid-State Formulations with Implications for Protein Stability.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00935
Targeted Lipid Nanoemulsions Encapsulating Epigenetic Drugs Exhibit Selective Cytotoxicity on CDH1-/FOXM1+ Triple Negative Breast Cancer Cells.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01065
Measuring the pancreatic beta cell mass in vivo with exendin SPECT during hyperglycemia and severe insulitis.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00728
Interplay of supersaturation and solubilization: Lack of correlation between concentration-based supersaturation measurements and membrane transport rates in simulated and aspirated human fluids.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00956
Combination Chemotherapy of L1210 Tumors in Mice with Pretubulysin and Methotrexate Lipo-Oligomer Nanoparticles.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00038
A New Methodology to Create Polymeric Nanocarriers Containing Hydrophilic Low Molecular-Weight Drugs: A Green Strategy Providing a Very High Drug Loading.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00097
Quantitative Imaging of the Hypoxia-Related Marker CAIX in Head and Neck Squamous Cell Carcinoma Xenograft Models
来源期刊：Molecular PharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00950
Detecting functional and accessible folate receptor expression in cancer and polycystic kidneys.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00624
111In-Labeled Glycoprotein Nonmetastatic b (GPNMB) Targeted Gemini Surfactant-Based Nanoparticles against Melanoma: In Vitro Characterization and in Vivo Evaluation in Melanoma Mouse Xenograft Model.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00831
Enhanced Reactive Oxygen Species Levels by Active Benzothiazole Complex mediated Fenton Reaction for Highly Effective Anti-tumor Therapy.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00819
Bifunctional Fusion Proteins Derived from Tumstatin and 4-1BBL for Targeted Cancer Therapy.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01190
Revealing Intermolecular Hydrogen Bonding Structure and Dynamics in a Deep Eutectic Pharmaceutical by Magic-Angle Spinning NMR Spectroscopy
来源期刊：Molecular PharmaceuticsDOI：10.1021/acs.molpharmaceut.9b01075
Impact of a Single Hydrogen Substitution by Fluorine on the Molecular Interaction and Miscibility between Sorafenib and Polymers.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b00970
Lung Tissue Delivery of Virus-Like Particles Mediated by Macrolide Antibiotics.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00180
Hydrophilic Small Molecules That Harness Transthyretin To Enhance the Safety and Efficacy of Targeted Chemotherapeutic Agents.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00432
Incorporation of complexation into coamorphous system dramatically enhances dissolution and eliminates gelation of amorphous lurasidone hydrochloride.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00772
Inhibiting hypoxia and chemotherapy-induced cancer cell metastasis under valid therapeutic effect by an assistance of biomimetic oxygen delivery.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00663
Enhanced oral bioavailability of 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) from its (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL) based prodrugs.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00637
A Novel Conjugate of Bis[((4-Bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex, Exhibits Specific Subcellular Localization in Mitochondria.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00608
Geometry of a TLR2-Agonist-Based Adjuvant Can Affect the Resulting Antigen-Specific Immune Response.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00026
Exendin-4 derivatives with an albumin-binding moiety show decreased renal retention and improved GLP-1 receptor targeting.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00271
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00472
Development of Arginine Anchored Nano-Globule with Retrograde Trafficking Inhibitor (Retro-2) for the Treatment of Enterohemorrhagic Escherichia coli outbreak.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00727
Vitamin E-conjugated phosphopeptide inhibitor of the polo-box domain of polo-like kinase 1.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00757
Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.8b01124
Optimizing lysosomal activation of antibody-drug conjugates (ADCs) by incorporation of novel cleavable dipeptide linkers.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00696
In situ Crystal Growth Rate Distributions of Active Pharmaceutical Ingredients.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00937
Investigations of albumin-insulin detemir complexes using molecular dynamics simulations and free energy calculations.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00839
Development of a Liposomal Formulation of Acetyltanshinone IIA for Breast Cancer Therapy.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00493
MRI Assessment of Prostate-Specific Membrane Antigen (PSMA) Targeting by a PSMA-Targeted Magnetic Nanoparticle: Potential for Image-Guided Therapy.
来源期刊：Molecular pharmaceuticsDOI：10.1021/acs.molpharmaceut.9b00036
