Molecular Neurodegeneration is an open access, peer-reviewed journal that encompasses all aspects of neurodegeneration research at the molecular and cellular levels.Neurodegenerative diseases collectively refer to neurological disorders that result from neurodegeneration and include, but are not limited to, Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion diseases. These diseases, which are often associated with advanced aging and display varying degrees of dementia, have become a significant public health issue as humans live longer and the aging population grows larger. Recent advances in the molecular and cellular mechanisms underlying the pathogenesis of these neurodegenerative disorders have allowed for a better understanding of the disease mechanisms.
《分子神经退行性变》是一本开放获取、同行评审的期刊，涵盖了神经退行性变研究在分子和细胞水平的所有方面。神经退行性疾病统称为神经退行性疾病，包括但不限于阿尔茨海默病、帕金森病、亨廷顿病和朊病毒疾病。随着人类寿命延长和老龄化人口增加，这些疾病通常与晚期衰老有关，并表现出不同程度的痴呆，已成为一个重要的公共卫生问题。这些神经退行性疾病发病机制的分子和细胞机制的最新进展使人们能够更好地理解疾病机制。
The neuropathological diagnosis of Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0333-5
Alpha-synuclein structure and Parkinson’s disease – lessons and emerging principles
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0329-1
Dementia with Lewy bodies: an update and outlook
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0306-8
Dural lymphatics regulate clearance of extracellular tau from the CNS
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0312-x
Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0323-7
Glial phagocytic clearance in Parkinson’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0314-8
Glucose transporter 1 critically controls microglial activation through facilitating glycolysis
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0305-9
Glucocerebrosidase and its relevance to Parkinson disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0336-2
α-synuclein in the pathophysiology of Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0320-x
Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0310-z
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0344-2
Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0324-6
Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0339-z
Impaired dopamine metabolism in Parkinson’s disease pathogenesis
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0332-6
Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0335-3
Differences in neurotropism and neurotoxicity among retrograde viral tracers
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0308-6
Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0315-7
Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0311-y
Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0307-7
Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0309-5
The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0318-4
Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0317-5
TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0319-3
Application of CRISPR genetic screens to investigate neurological diseases
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0343-3
Neurofilament light chain is a promising serum biomarker in spinocerebellar ataxia type 3
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0338-0
Pineal gland dysfunction in Alzheimer’s disease: relationship with the immune-pineal axis, sleep disturbance, and neurogenesis
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0330-8
Wild-type Cu/Zn-superoxide dismutase is misfolded in cerebrospinal fluid of sporadic amyotrophic lateral sclerosis
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0341-5
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0337-1
Targeting tauopathy with engineered tau-degrading intrabodies
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0340-6
Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0342-4
Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0316-6
Neuroimaging Biomarkers for Alzheimer’s Disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0325-5
Organotypic brain slice cultures to model neurodegenerative proteinopathies
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0346-0
Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0327-3
Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0322-8
Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0353-1
Generating microglia from human pluripotent stem cells: novel in vitro models for the study of neurodegeneration
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0347-z
A CRISPR monkey model unravels a unique function of PINK1 in primate brains
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0321-9
Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0313-9
A circuit view of deep brain stimulation in Alzheimer’s disease and the possible mechanisms
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0334-4
Targeted disruption of dual leucine zipper kinase and leucine zipper kinase promotes neuronal survival in a model of diffuse traumatic brain injury
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0345-1
Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0352-2
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0351-3
Correction to: Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0331-7
BrightFocus Alzheimer’s Fast Track 2019
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0348-y
The 5th International Conference on Molecular Neurodegeneration: Overlapping Pathologies and Common Mechanisms
来源期刊：Molecular NeurodegenerationDOI：10.1186/s13024-019-0328-2
