Molecular Cancer Research publishes articles describing novel basic cancer research discoveries of broad interest to the field. Studies must be of demonstrated significance, and the journal prioritizes analyses performed at the molecular and cellular level that reveal novel mechanistic insight into pathways and processes linked to cancer risk, development, and/or progression. Areas of emphasis include all cancer-associated pathways (including cell-cycle regulation; cell death; chromatin regulation; DNA damage and repair; gene and RNA regulation; genomics; oncogenes and tumor suppressors; signal transduction; and tumor microenvironment), in addition to studies describing new molecular mechanisms and interactions that support cancer phenotypes. For full consideration, primary research submissions must provide significant novel insight into existing pathway functions or address new hypotheses associated with cancer-relevant biologic questions.
《分子癌症研究》发表文章描述了该领域广泛感兴趣的新的基础癌症研究发现。研究必须具有证明的意义，该杂志优先考虑在分子和细胞水平上进行的分析，这些分析揭示了与癌症风险、发展和/或进展相关的通路和过程的新机制。重点领域包括所有癌症相关途径（包括细胞周期调控;细胞死亡;染色质调节; DNA损伤与修复;基因和RNA调节;癌基因和肿瘤抑制因子;信号转导;和肿瘤微环境），以及描述支持癌症表型的新分子机制和相互作用的研究。为了充分考虑，初步研究提交必须提供对现有通路功能的重要新见解或解决与癌症相关生物学问题相关的新假设。
Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1147
MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0910
The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0191
SPHK1 Is a Novel Target of Metformin in Ovarian Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0409
O-GlcNAcylation Enhances Double-Strand Break Repair, Promotes Cancer Cell Proliferation, and Prevents Therapy-Induced Senescence in Irradiated Tumors
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1025
Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0407
Sophoridine Inhibits Human Colorectal Cancer Progression via Targeting MAPKAPK2
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0553
AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1372
Dual TGFβ/BMP Pathway Inhibition Enables Expansion and Characterization of Multiple Epithelial Cell Types of the Normal and Cancerous Breast
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0165
Characterization of HCC Mouse Models: Towards an Etiology-Oriented Subtyping Approach
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1045
Evaluation of Tumor Cell–Tumor Microenvironment Component Interactions as Potential Predictors of Patient Response to Napabucasin
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1242
Targeting IDH1 as a Prosenescent Therapy in High-grade Serous Ovarian Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1233
Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0638
BRD4 Regulates Metastatic Potential of Castration-Resistant Prostate Cancer through AHNAK
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1279
Identification of Genes Regulating Breast Cancer Dormancy in 3D Bone Endosteal Niche Cultures
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0956
HBx-K130M/V131I Promotes Liver Cancer in Transgenic Mice via AKT/FOXO1 Signaling Pathway and Arachidonic Acid Metabolism
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1127
Loss of MAP3K7 Sensitizes Prostate Cancer Cells to CDK1/2 Inhibition and DNA Damage by Disrupting Homologous Recombination
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1335
Prostate Tumor Cell–Derived IL1β Induces an Inflammatory Phenotype in Bone Marrow Adipocytes and Reduces Sensitivity to Docetaxel via Lipolysis-Dependent Mechanisms
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0540
RAIN Is a Novel Enhancer-Associated lncRNA That Controls RUNX2 Expression and Promotes Breast and Thyroid Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0564
Identification and Characterization of Oncogenic SOS1 Mutations in Lung Adenocarcinoma
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0316
β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1352
The Pioneering Role of GATA2 in Androgen Receptor Variant Regulation Is Controlled by Bromodomain and Extraterminal Proteins in Castrate-Resistant Prostate Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1231
Galectin-3 Interacts with C/EBPβ and Upregulates Hyaluronan-Mediated Motility Receptor Expression in Gastric Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0811
UBE2C Is Upregulated by Estrogen and Promotes Epithelial–Mesenchymal Transition via p53 in Endometrial Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0561
Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0048
TFE3 Xp11.2 Translocation Renal Cell Carcinoma Mouse Model Reveals Novel Therapeutic Targets and Identifies GPNMB as a Diagnostic Marker for Human Disease
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1235
Multiple Defects Sensitize p53-Deficient Head and Neck Cancer Cells to the WEE1 Kinase Inhibition
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0860
Prostate Cancer in World Trade Center Responders Demonstrates Evidence of an Inflammatory Cascade
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0115
Interaction Between MUC1 and STAT1 Drives IFITM1 Overexpression in Aromatase Inhibitor–Resistant Breast Cancer Cells and Mediates Estrogen-Induced Apoptosis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0916
The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0493
Reactive Oxygen Species (ROS)-Inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1071
Growth Factor–Independent 1 Is a Tumor Suppressor Gene in Colorectal Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0666
PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0204
Ovarian Tumor Cell Expression of Claudin-4 Reduces Apoptotic Response to Paclitaxel
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0451
Breast Cancer Risk–Associated SNPs in the mTOR Promoter Form De Novo KLF5- and ZEB1-Binding Sites that Influence the Cellular Response to Paclitaxel
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1072
Estrogen-Induced Apoptosis in Breast Cancers Is Phenocopied by Blocking Dephosphorylation of Eukaryotic Initiation Factor 2 Alpha (eIF2α) Protein
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0481
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-0933
Hypoxia-Associated Factor (HAF) Mediates Neurofibromin Ubiquitination and Degradation Leading to Ras–ERK Pathway Activation in Hypoxia
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1080
Intron 1–Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0747
Pharmacologic Ascorbate Primes Pancreatic Cancer Cells for Death by Rewiring Cellular Energetics and Inducing DNA Damage
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0381
The Zinc-Finger AN1-Type Domain 2a Gene Acts as a Regulator of Cell Survival in Human Melanoma: Role of E3-Ligase cIAP2
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0243
Capping Protein Regulator and Myosin 1 Linker 3 Is Required for Tumor Metastasis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0722
Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0408
Treating Cancer as an Invasive Species
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0262
Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0402
“MPNST Epigenetics”—Letter
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.mcr-19-0680
T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0227
Acknowledgment to Reviewers
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.mcr_17_1_reviewers
A Novel FGFR3 Splice Variant Preferentially Expressed in African American Prostate Cancer Drives Aggressive Phenotypes and Docetaxel Resistance
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-19-0415
The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch–Nodal Axis
来源期刊：Molecular Cancer ResearchDOI：10.1158/1541-7786.MCR-18-1292
