This journal is an international medium directed towards the needs of academic, clinical, government and industrial analysis by publishing original research reports and critical reviews on pharmaceutical and biomedical analysis. It covers the interdisciplinary aspects of analysis in the pharmaceutical, biomedical and clinical sciences, including developments in analytical methodology, instrumentation, computation and interpretation. Submissions on novel applications focusing on drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling; drug-related aspects of analytical biochemistry and forensic toxicology; quality assurance in the pharmaceutical industry are also welcome.Studies from areas of well established and poorly selective methods, such as UV-VIS spectrophotometry (including derivative and multi-wavelength measurements), basic electroanalytical (potentiometric, polarographic and voltammetric) methods, fluorimetry, flow-injection analysis, etc. are accepted for publication in exceptional cases only, if a unique and substantial advantage over presently known systems is demonstrated. The same applies to the assay of simple drug formulations by any kind of methods and the determination of drugs in biological samples based merely on spiked samples. Drug purity/stability studies should contain information on the structure elucidation of the impurities/degradants.
该杂志是一个国际媒体，通过发表原创研究报告和对制药和生物医学分析的评论，满足学术、临床、政府和工业分析的需要。它涵盖了制药、生物医学和临床科学中分析的跨学科方面，包括分析方法学、仪器、计算和解释的发展。关于药物纯度和稳定性研究、药代动力学、治疗监测、代谢特征分析的新申请的提交;分析生物化学和法医毒理学中与药物有关的方面;在制药工业中的质量保证也是受欢迎的。来自已经建立和选择性差的方法领域的研究，如紫外-可见分光光度法（包括导数和多波长测量），基本电分析（电位测定法、极谱法和伏安法） 、荧光测定法、流动注射分析法等仅在例外情况下可用于发表，如果展示出优于目前已知系统的独特和实质性优点，则本发明的系统和方法将是有益的。这同样适用于通过任何类型的方法对简单药物制剂的测定以及仅基于加标样品对生物样品中的药物的测定。药物纯度/稳定性研究应包含杂质/降解产物的结构解析信息。
Characterization of tolazamide binding with glycated and normal human serum albumin by using high‐performance affinity chromatography
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.01.025
Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.05.065
Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.02.016
Enantioselective recognition of sutezolid by cyclodextrin modified non‐aqueous capillary electrophoresis and explanation of complex formation by means of infrared spectroscopy, NMR and molecular modelling
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.02.033
Monolith weak affinity chromatography for &mgr;g‐protein‐ligand interaction study
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.01.012
Simultaneous determination of calycosin‐7‐O‐&bgr;‐D‐glucoside, cinnamic acid, paeoniflorin and albiflorin in rat plasma by UHPLC‐MS/MS and its application to a pharmacokinetic study of Huangqi Guizhi Wuwu Decoction
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.03.022
Determination of chemical stability of sitagliptin by LC‐UV, LC‐MS and FT‐IR methods
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2018.11.023
Determination of tyrosine kinase inhibitor afatinib in rat plasma using LC–MS/MS and its application to in vivo pharmacokinetic studies of afatinib liposomes
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2018.10.043
Development of a chemical fingerprint as a tool to distinguish closely related Tinospora species and quantitation of marker compounds.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112894
An improved 2D-HPLC-UF-ESI-TOF/MS approach for enrichment and comprehensive characterization of minor neuraminidase inhibitors from Flos Lonicerae Japonicae.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.07.006
Fatty acids-based microemulsion liquid chromatographic determination of multiple caffeoylquinic acid isomers and caffeic acid in honeysuckle sample.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.03.064
Quantification of estradiol cypionate in plasma by liquid chromatography coupled with tandem mass spectrometry: Application in a pharmacokinetic study in healthy female volunteers
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.03.053
A comparative study of UHPLC/Orbitrap MS metabolomics profiles and biological properties of Asphodeline taurica from Bulgaria and Turkey
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.02.008
Rapid profiling of alkaloid analogues in Sinomenii Caulis by an integrated characterization strategy and quantitative analysis.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.06.011
LC-MS/MS combined with in vivo microdialysis sampling from conscious rat striatum for simultaneous determination of active constituents of Yuanhu- Baizhi herb pair and endogenous neurotransmitters: Application to pharmacokinetic and pharmacodynamic study.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112807
Metabolic profiling of chronic obstructive pulmonary disease model rats and the interventional effects of HuaTanJiangQi decoction using UHPLC-Q-TOF/MSE.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.113078
Development of formaldehyde dehydrogenase‐coupled assay and antibody‐based assays for ALKBH5 activity evaluation
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2018.09.018
Chemical profiling of Coptis rootlet and screening of its bioactive compounds in inhibiting Staphylococcus aureus by UPLC-Q-TOF/MS.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.113089
Benchtop NMR spectroscopy in the analysis of substandard and falsified medicines as well as illegal drugs.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112939
Development and validation of in-line near-infrared spectroscopy based analytical method for commercial production of a botanical drug product.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.06.046
Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/J.JPBA.2019.04.032
Electrochemical oxidation of selected immunosuppressants and identification of their oxidation products by means of liquid chromatography and tandem mass spectrometry (EC-HPLC-MS/MS).
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112799
Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.113019
Metabolite distribution and correlation studies of Ziziphus jujuba and Ziziphus nummularia using LC-ESI-MS/MS.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112918
Systematic screening and characterization of prototype constituents and metabolites of triterpenoid saponins of Caulopphyllum robustum Maxim using UPLC‐LTQ Orbitrap MS after oral administration in rats
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.02.005
A HILIC-MS/MS assay for the quantification of metformin and sitagliptin in human plasma and urine: A tool for studying drug transporter perturbation.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.07.002
Role of esterase mediated hydrolysis of simvastatin in human and rat blood and its impact on pharmacokinetic profiles of simvastatin and its active metabolite in rat
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.02.004
Determination of azathioprine/6-mercaptopurine metabolites in dried blood spots: Correlation with RBC concentrations.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112870
An unexpected Griess reaction on the important anti-malarial drug primaquine and its application for drug determination.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.03.063
Determination of total and free voriconazole in human plasma: Application to pharmacokinetic study and therapeutic monitoring.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112952
In vitro selection of tacrolimus binding aptamer by systematic evolution of ligands by exponential enrichment method for the development of a fluorescent aptasensor for sensitive detection of tacrolimus.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112853
Identification and characterization of co-purifying CHO host cell proteins in monoclonal antibody purification process.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.06.021
Qualitative and quantitative analysis of Yifei Tongluo granules to identify main bioactive components using LC–DAD/MS and pharmacokinetic studies
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2018.09.017
Determination of oligonucleotide deamination by high resolution mass spectrometry.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.05.012
Comparison of isotope pattern deconvolution and calibration curve quantification methods for the determination of estrone and 17β-estradiol in human serum.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.04.013
Pharmacokinetic study on bruceoside A revealed the potential role of quassinoid glycosides for the anticancer properties of Fructus Bruceae
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.03.052
UIISScan 1.1: A Field portable high-throughput platform tool for biomedical and agricultural applications.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.05.042
Analysis of unstable degradation impurities of a benzodiazepine and their quantification without isolation using multiple linear regression
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.01.028
Quantification of urinary derivatives of Phenylbutyric and Benzoic acids by LC-MS/MS as treatment compliance biomarkers in Urea Cycle disorders.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112798
Development of a UPLC-ESI-MS method for simultaneous determination of flavonoids and diterpenes in Egletes viscosa (L.) Less herbal products.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.01.008
Simultaneous analysis of volatile and semi-volatile components in a topical formulation by gas chromatography using a programmed temperature vaporization inlet and flame ionization detection.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.03.057
Nano electrospray differential mobility analysis based size-selection of liposomes and very-low density lipoprotein particles for offline hyphenation to MALDI mass spectrometry.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112998
Post-column infused internal standard assisted lipidomics profiling strategy and its application on phosphatidylcholine research.
来源期刊：Journal of pharmaceutical and biomedical analysisDOI：10.1016/j.jpba.2019.112956
Characterization of in vitro metabolism of focal adhesion kinase inhibitors by LC/MS/MS
来源期刊：Journal of Pharmaceutical and Biomedical AnalysisDOI：10.1016/j.jpba.2019.02.028
