ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.
ACS化学生物学提供了一个快速交流研究的国际论坛，广泛地涵盖了化学和生物学之间的接口。该杂志也作为一个论坛，促进生物学家和化学家之间的交流，这将转化为新的研究机会和发现。通过体外研究、细胞生物学方法或有机体研究，利用分子推理探索问题的结果将被发表。我们欢迎对蛋白质、核酸、糖、脂类和非生物聚合物的机理研究。该杂志服务于一个庞大的科学团体，从化学和生物学的角度探索细胞功能。据了解，提交的工作是基于原始结果，以前没有发表过。
Bioactivity-HiTES Unveils Cryptic Antibiotics Encoded in Actinomycete Bacteria.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00049
PF-06651600, a Dual JAK3/TEC Family Kinase Inhibitor.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00188
Salinipeptins: Integrated Genomic and Chemical Approaches Reveal Unusual d-Amino Acid-Containing Ribosomally Synthesized and Post-Translationally Modified Peptides (RiPPs) from a Great Salt Lake Streptomyces sp.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b01058
L,D-Transpeptidase Specific Probe Reveals Spatial Activity of Peptidoglycan Cross-Linking
来源期刊：ACS Chemical BiologyDOI：10.1021/acschembio.9b00427
Esterase-Triggered Self-Immolative Thiocarbamates Provide Insights into COS Cytotoxicity.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00981
Cu-ATCUN Derivatives of Sub5 Exhibit Enhanced Antimicrobial Activity via Multiple Modes of Action.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b01087
Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00369
Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00948
Processivity in Bacterial Glycosyltransferases
来源期刊：ACS Chemical BiologyDOI：10.1021/acschembio.9b00619
Engineered Aminoacyl-tRNA Synthetases with Improved Selectivity toward Noncanonical Amino Acids.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00088
Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b01025
Optimization of Ligands using Focused DNA-encoded Libraries to Develop a Selective, Cell-permeable CBX8 Chromodomain Inhibitor.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00654
Procaspase-3 Overexpression in Cancer: A Paradoxical Observation with Therapeutic Potential.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00338
Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI
来源期刊：ACS Chemical BiologyDOI：10.1021/acschembio.8b00969
Identification of C-β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
来源期刊：ACS chemical biologyDOI：10.1021/ACSCHEMBIO.9B00172
Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of α-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00354
Genome Mining Reveals Endopyrroles from a Nonribosomal Peptide Assembly Line Triggered in Fungal-Bacterial Symbiosis.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00406
Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00490
Metabolic Regulation of the Epitranscriptome.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00951
Leveraging new definitions of the LxVP SLiM to discover novel Calcineurin regulators and substrates.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00606
Direct evidence for an enzyme generated LPP intermediate in (+)-limonene synthase using a fluorinated GPP substrate analog.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00514
YTHDF2 recognition of N1-methyladenosine (m1A)-modified RNA is associated with transcript destabilization.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00655
Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00593
A Chemical Inhibitor of Cell Growth Reduces Cell Size in Bacillus subtilis.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b01066
Pandonodin: a proteobacterial lasso peptide with an exceptionally long C-terminal tail.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00676
Regulatory Mechanisms of the Mucin-Like Region on Herpes Simplex Virus during Cellular Attachment.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00064
Peptide-Membrane Interactions Affect the Inhibitory Potency and Selectivity of Spider Toxins ProTx-II and GpTx-1.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00989
Systematic diversity-oriented synthesis of reduced flavones from γ-pyrones to probe biological performance diversity.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00294
Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases.
来源期刊：ACS chemical biologyDOI：10.1021/ACSCHEMBIO.9B00323
Discovery of PqsE Thioesterase Inhibitors for Pseudomonas aeruginosa using DNA-Encoded Small Molecule Library Screening.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00905
Transcriptional Bypass of DNA-protein and DNA-peptide Conjugates by T7 RNA Polymerase.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00365
Lost in (Clinical) Translation: Recent Advances in Heparin Neutralization and Monitoring.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00772
An Autoinducer Analogue Reveals an Alternative Mode of Ligand Binding for the LasR Quorum-Sensing Receptor.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00971
A single-component flavoenzyme catalyzed regioselective halogenation of pyrone in the biosynthesis of venemycins.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00554
Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00651
The Diiron Monooxygenase CmlA from Chloramphenicol Biosynthesis Allows Reconstitution of β-Hydroxylation during Glycopeptide Antibiotic Biosynthesis
来源期刊：ACS Chemical BiologyDOI：10.1021/acschembio.9b00862
Identification of Bioactive Small Molecule Inhibitors of Separase.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00661
Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00292
Engineered chymotrypsiN for mass-spectrometry based detection of protein glycosylation.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00506
Activation of Ralfuranone/Ralstonin Production by Plant Sugars Functions in the Virulence of Ralstonia solanacearum.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00301
Amino Acid Residues Recognizing Isomeric Glutamate Substrates in UDP- N-acetylmuramic acid-l-alanine-glutamate Synthetases.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00159
High Sensitivity of Human Translesion DNA Synthesis Polymerase κ to Variation in O6-Carboxymethylguanine Structures.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b00802
Immunological Evaluation of Synthetic Glycosylphosphatidylinositol Glycoconjugates as Vaccine Candidates Against Malaria.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00739
Development of a Nitric Oxide-Responsive Labeling Reagent for Proteome Analysis of Live Cells.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.8b01021
A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00002
Leveraging peptide substrate libraries to design inhibitors of bacterial Lon protease.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00529
Morphological Deconvolution of Beta-Lactam Polyspecificity in E. coli.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00141
Dimensionally Enhanced Antibacterial Library Screening.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00745
Immunity guided identification of threonyl-tRNA synthetase as the molecular target of obafluorin, a beta-lactone antibiotic.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00590
Mapping RNAPII CTD phosphorylation reveals that the identity and modification of seventh heptad residues direct Tyr1 phosphorylation.
来源期刊：ACS chemical biologyDOI：10.1021/acschembio.9b00610
