Journal of Neuroinflammation is an open access, peer-reviewed journal that focuses on interactions of the immune system (and especially the innate immune system) with the nervous system. This includes the roles of CNS immune mediators (such as microglia and astrocytes, and their expressed cytokines and chemokines) as well as the roles of peripheral neuro-immune interactions, T cells, monocytes, complement proteins, acute phase proteins, oxidative injury and related molecular processes.Neuroinflammation is a rapidly expanding field that has revolutionized our understanding of chronic neurological diseases. This field has grown to encompass researchers with backgrounds in many diverse fields, including pathology, biochemistry, molecular biology, genetics, clinical medicine, and epidemiology. Important contributions to this field have come from work with populations, patients, postmortem tissues, animal models, and in vitro systems.Journal of Neuroinflammation brings together work focusing on common pathogenic processes, and provides a forum for integrative reviews and commentaries on this field.
《神经炎症杂志》（Journal of Neuroinflamation）是一本开放获取、同行评审的期刊，主要关注免疫系统（尤其是先天免疫系统）与神经系统的相互作用。这包括中枢神经系统免疫介质（如小胶质细胞和星形胶质细胞及其表达的细胞因子和趋化因子）的作用以及外周神经-免疫相互作用、T细胞、单核细胞、补体蛋白、急性期蛋白、氧化损伤和相关分子过程的作用。这个领域已经发展到包括许多不同领域背景的研究人员，包括病理学、生物化学、分子生物学、遗传学、临床医学和流行病学。对这一领域的重要贡献来自于对人群、患者、死后组织、动物模型和体外系统的研究。《神经炎症杂志》汇集了集中于常见致病过程的工作，并提供了一个论坛，对这一领域进行综合评论和评论。
A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1471-y
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1490-8
The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1423-6
The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1424-5
Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1417-4
Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1449-9
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1627-9
Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1521-5
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1592-3
Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1396-5
Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1549-6
BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1511-7
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1495-3
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1472-x
Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1512-6
Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1467-7
The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1509-1
The history of neuromyelitis optica. Part 2: ‘Spinal amaurosis’, or how it all began
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1594-1
Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1570-9
Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1462-z
Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1534-0
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1455-y
Systemic TLR2 tolerance enhances central nervous system remyelination
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1540-2
Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1598-x
Immunomodulatory and anti-inflammatory effects of probiotics in multiple sclerosis: a systematic review
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1611-4
Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1465-9
Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1565-6
Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1685-z
TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1579-0
Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1510-8
Dynamic response of microglia/macrophage polarization following demyelination in mice
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1586-1
Osteopontin and its spatiotemporal relationship with glial cells in the striatum of rats treated with mitochondrial toxin 3-nitropropionic acid: possible involvement in phagocytosis
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1489-1
The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1682-2
Distinct migratory pattern of naive and effector T cells through the blood–CSF barrier following Echovirus 30 infection
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1626-x
Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1583-4
Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1669-z
Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1679-x
The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1518-0
The role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1634-x
Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1596-z
Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1600-7
Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1420-9
TNFα inhibitors as targets for protective therapies in MSA: a viewpoint
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1477-5
CD147 as a key mediator of the spleen inflammatory response in mice after focal cerebral ischemia
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1609-y
KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1686-y
Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1639-5
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1502-8
Mo-derived perivascular macrophage recruitment protects against endothelial cell death in retinal vein occlusion
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1547-8
Cellular source of hypothalamic macrophage accumulation in diet-induced obesity
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1607-0
Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
来源期刊：Journal of NeuroinflammationDOI：10.1186/s12974-019-1501-9
