Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions.Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.
《分子生物学杂志》（JMB）提供高质量、全面和广泛的报道，涵盖分子生物学的所有领域。该杂志发表原创的科学研究论文，提供机械和功能的见解，并报告了该领域的重大进展。该杂志鼓励提交多学科的研究，使用互补的实验和计算方法来解决具有挑战性的生物学问题。研究领域包括但不限于：生物分子相互作用、信号网络、系统生物学;细胞周期、细胞生长、细胞分化;细胞死亡、自噬;细胞信号传导与调控;化学生物学;计算生物学与实验研究相结合; DNA复制、修复和重组;干细胞的发育、再生生物学、机理和功能研究;表观遗传学、染色质结构与功能;基因表达;膜过程、细胞表面蛋白和细胞间相互作用;实验和理论方面的方法进展，包括数据库;微生物学、病毒学以及与宿主或环境的相互作用;微生物群机理和功能研究;核组织;翻译后修饰，蛋白质组学;生物学重要大分子和复合物的加工和功能;疾病的分子基础; RNA加工、非编码RNA的结构和功能、转录;整理、时空组织、贩运;结构生物学合成生物学翻译、蛋白质折叠、蛋白伴侣、蛋白质降解和质量控制。
Clarifying the Link between Toxin-Antitoxin Modules and Bacterial Persistence.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.019
Functional Genomics via CRISPR-Cas.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2018.06.034
G-Quadruplexes in Human Ribosomal RNA.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.010
Analyzing Microbial Population Heterogeneity-Expanding the Toolbox of Microfluidic Single-Cell Cultivations.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.04.025
Crossroads of Antibiotic Resistance and Biosynthesis.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.06.033
Microglia-Specific Metabolic Changes in Neurodegeneration.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.006
Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.02.004
Mechanisms of Autophagy in Metabolic Stress Response.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.09.005
A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator
来源期刊：Journal of Molecular BiologyDOI：10.1016/j.jmb.2019.04.041
Changing the Apoptosis Pathway through Evolutionary Protein Design.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2018.12.016
Lipids and lipid-binding proteins in selective autophagy.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.05.051
In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase.
来源期刊：Journal of molecular biologyDOI：10.1016/J.JMB.2019.06.016
Ubiquitin and Receptor Dependent Mitophagy Pathways and Their Implication in Neurodegeneration.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.10.015
DEPICTER: intrinsic disorder and disorder function prediction server.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.12.030
How B-DNA Dynamics Decipher Sequence-Selective Protein Recognition.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.07.021
Coordination of a single calcium ion in the EF-hand maintains the off state of the stromal interaction molecule luminal domain.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.10.003
Menacing Mold: Recent Advances in Aspergillus Pathogenesis and Host Defense.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.027
Transcription-Coupled Repair: From Cells to Single Molecules and Back Again.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.05.040
Higher-order chromosomal structures mediate genome function.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.10.014
The Phosphatase PRL-3 Is Involved in Key Steps of Cancer Metastasis.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.06.008
Ensembles from Ordered and Disordered Proteins Reveal Similar Structural Constraints during Evolution.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.01.031
Tracking the stepwise movement of a membrane-inserting protein in vivo.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.10.010
Crystal Structures of Csm2 and Csm3 in the Type III-A CRISPR-Cas Effector Complex.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.01.009
Biotechnological Applications of MBD Domain Proteins for DNA Methylation Analysis.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.08.020
Good gone bad: One toxin away from disease for Bacteroides fragilis.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.12.003
Acetylation of Response Regulator Proteins, TcrX and MtrA in M. tuberculosis Tunes their Phosphotransfer Ability and Modulates Two-Component Signaling Crosstalk.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.01.004
Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.009
Protein Abundance Biases the Amino Acid Composition of Disordered Regions to Minimize Non-functional Interactions
来源期刊：Journal of Molecular BiologyDOI：10.1016/j.jmb.2019.08.008
Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate its Catalytic Activity.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.06.021
Multiple Mechanisms Are Involved in Repression of Filamentous Phage SW1 Transcription by the DNA-Binding Protein FpsR.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.01.040
Blood-Stage Malaria Parasite Antigens: Structure, Function, and Vaccine Potential.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.05.018
Functional Conservation of lncRNA JPX despite Sequence and Structural Divergence.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.09.002
RNA Sequence Features Are at the Core of Influenza A Virus Genome Packaging.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.018
Stability and Inter-domain Interactions Modulate Amyloid Binding Activity of a General Amyloid Interaction Motif.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.022
Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain
来源期刊：Journal of Molecular BiologyDOI：10.1016/j.jmb.2019.04.013
Organization of Farnesylated, Carboxymethylated KRAS4B on Membranes.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.07.025
Mobile loops and electrostatic interactions maintainthe flexible tail tube of bacteriophage lambda.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.10.031
Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2018.12.010
Structural heterogeneity in the pre-amyloid oligomers of β-2-microglobulin.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.10.030
Heterogeneous Timing of Gene Induction as a Regulation Strategy.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.05.020
Near-Neighbor Interactions in the NS3-4A Protease of HCV Impact Replicative Fitness of Drug-Resistant Viral Variants.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.04.034
Biochemical Studies Provide Insights into the Necessity for Multiple Arabidopsis thaliana Protein-Only RNase P Isoenzymes.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2018.11.004
The Third Intron of IRF8 Is a Cell-Type-Specific Chromatin Priming Element during Mouse Embryonal Stem Cell Differentiation.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2018.11.022
Influence of Cholesterol and Its Stereoisomers on Members of the Serotonin Receptor Family.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.02.030
Structure-Guided Generation of a Redox-Independent Blue Fluorescent Protein from mBFP.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.06.005
Allosteric cooperativity in proton energy conversion in A1-type cytochrome c oxidase.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.09.027
Transcriptional fidelity of mitochondrial RNA polymerase RpoTm from Arabidopsis thaliana.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.08.022
Dropping Out and Other Fates of Transmembrane Segments Inserted by the SecA ATPase.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.03.021
Truncated, non-networking versions of the coupling protein CheW retain chemoreceptor control of kinase CheA.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.09.009
Ribosomal protein L11 selectively stabilizes a tertiary structure of the GTPase Center rRNA domain.
来源期刊：Journal of molecular biologyDOI：10.1016/j.jmb.2019.12.010
