Uncovering mechanisms in biology, gaining insights into physiology and diseaseScience Signaling is a weekly, online multidisciplinary journal for the life sciences. The aim of the journal editors is to publish studies that uncover the basic mechanisms that underlie biological processes across all organisms. Particular emphasis is placed on studies that provide new insights into physiology; delineate aberrant mechanisms that cause disease; identify new potential therapeutic targets and strategies; and characterize the effects of drugs in vitro and in vivo.
揭示生物学机制，深入了解生理学和疾病科学信号是一个每周，在线多学科的生命科学杂志。期刊编辑的目标是发表研究，揭示所有生物体的生物过程的基本机制。特别强调提供生理学新见解的研究;描述引起疾病的异常机制;确定新的潜在治疗靶点和策略;并表征药物在体外和体内的作用。
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
来源期刊：Science SignalingDOI：10.1126/scisignal.aau4543
The human secretome
来源期刊：Science SignalingDOI：10.1126/scisignal.aaz0274
mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis
来源期刊：Science SignalingDOI：10.1126/scisignal.aav3048
Tracing the origin and evolution of pseudokinases across the tree of life
来源期刊：Science SignalingDOI：10.1126/scisignal.aav3810
Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology
来源期刊：Science SignalingDOI：10.1126/scisignal.aay0300
Host mitochondria influence gut microbiome diversity: A role for ROS
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw3159
Flotillin-mediated endocytosis and ALIX–syntenin-1–mediated exocytosis protect the cell membrane from damage caused by necroptosis
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw3423
Long noncoding RNA NEAT1 mediates neuronal histone methylation and age-related memory impairment
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw9277
Cooperation between T cell receptor and Toll-like receptor 5 signaling for CD4+ T cell activation
来源期刊：Science SignalingDOI：10.1126/scisignal.aar3641
Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance
来源期刊：Science SignalingDOI：10.1126/scisignal.aas8779
LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses
来源期刊：Science SignalingDOI：10.1126/scisignal.aar3993
Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis
来源期刊：Science SignalingDOI：10.1126/scisignal.aax0715
TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction
来源期刊：Science SignalingDOI：10.1126/scisignal.aau2281
CD13 tethers the IQGAP1-ARF6-EFA6 complex to the plasma membrane to promote ARF6 activation, β1 integrin recycling, and cell migration
来源期刊：Science SignalingDOI：10.1126/scisignal.aav5938
Perspectives on the role of Wnt biology in cancer
来源期刊：Science SignalingDOI：10.1126/scisignal.aay4494
Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility
来源期刊：Science SignalingDOI：10.1126/scisignal.aau1468
The induction of HAD-like phosphatases by multiple signaling pathways confers resistance to the metabolic inhibitor 2-deoxyglucose
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw8000
Carbohydrate-dependent B cell activation by fucose-binding bacterial lectins
来源期刊：Science SignalingDOI：10.1126/scisignal.aao7194
Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β
来源期刊：Science SignalingDOI：10.1126/scisignal.aax4067
iRhom2 inhibits bile duct obstruction–induced liver fibrosis
来源期刊：Science SignalingDOI：10.1126/scisignal.aax1194
Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation
来源期刊：Science SignalingDOI：10.1126/scisignal.aau1533
Diacylglycerol kinase ζ promotes allergic airway inflammation and airway hyperresponsiveness through distinct mechanisms
来源期刊：Science SignalingDOI：10.1126/scisignal.aax3332
Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw4204
Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw2300
The interaction of ceramide 1-phosphate with group IVA cytosolic phospholipase A2 coordinates acute wound healing and repair
来源期刊：Science SignalingDOI：10.1126/scisignal.aav5918
Biased M1 receptor–positive allosteric modulators reveal role of phospholipase D in M1-dependent rodent cortical plasticity
来源期刊：Science SignalingDOI：10.1126/scisignal.aax2057
Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3–stimulated murine basophils
来源期刊：Science SignalingDOI：10.1126/scisignal.aav2060
The Ca2+ export pump PMCA clears near-membrane Ca2+ to facilitate store-operated Ca2+ entry and NFAT activation
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw2627
CARD9 mediates dendritic cell–induced development of Lyn deficiency–associated autoimmune and inflammatory diseases
来源期刊：Science SignalingDOI：10.1126/scisignal.aao3829
SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw3469
Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation
来源期刊：Science SignalingDOI：10.1126/scisignal.aap7584
Nucleotide exchange–dependent and nucleotide exchange–independent functions of plant heterotrimeric GTP-binding proteins
来源期刊：Science SignalingDOI：10.1126/scisignal.aav9526
Eye on ion channels in immune cells
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw8014
Thiol-based direct threat sensing by the stress-activated protein kinase Hog1
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw4956
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
来源期刊：Science SignalingDOI：10.1126/scisignal.aao0736
Mitochondrial respiration not required
来源期刊：Science SignalingDOI：10.1126/scisignal.aay2985
Driving expression of leptin
来源期刊：Science SignalingDOI：10.1126/scisignal.aax7601
PAF and the inflammasome
来源期刊：Science SignalingDOI：10.1126/scisignal.aaz7370
CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2
来源期刊：Science SignalingDOI：10.1126/scisignal.aaw2040
Activating cGAS at the right time and place
来源期刊：Science SignalingDOI：10.1126/scisignal.aax4336
Lipidating a ubiquitin ligase
来源期刊：Science SignalingDOI：10.1126/scisignal.aay5593
Chromatin serotonylation limits differentiation
来源期刊：Science SignalingDOI：10.1126/scisignal.aau2218
Bugs in the gut dictate food allergy
来源期刊：Science SignalingDOI：10.1126/scisignal.aay7815
SOCE, mitochondria, and inflammation
来源期刊：Science SignalingDOI：10.1126/scisignal.aay1437
Stress, age, and cancer
来源期刊：Science SignalingDOI：10.1126/scisignal.aaz4717
Lactylation drives resolution
来源期刊：Science SignalingDOI：10.1126/scisignal.aba0502
Stepping out of the shadow: STIM2 promotes IL-3–induced cytokine release
来源期刊：Science SignalingDOI：10.1126/scisignal.aax0210
Turning off cellular stress
来源期刊：Science SignalingDOI：10.1126/scisignal.aax9738
New connections: Decoding macrophages in disease
来源期刊：Science SignalingDOI：10.1126/scisignal.aax6493
PIEZO1 promotes inflammation
来源期刊：Science SignalingDOI：10.1126/scisignal.aaz4154
