Psychiatry has suffered tremendously by the limited translational pipeline. Nobel laureate Julius Axelrod's discovery in 1961 of monoamine reuptake by pre-synaptic neurons still forms the basis of contemporary antidepressant treatment. There is a grievous gap between the explosion of knowledge in neuroscience and conceptually novel treatments for our patients. Translational Psychiatry bridges this gap by fostering and highlighting the pathway from discovery to clinical applications, healthcare and global health. We view translation broadly as the full spectrum of work that marks the pathway from discovery to global health, inclusive. The steps of translation that are within the scope of Translational Psychiatry include (i) fundamental discovery, (ii) bench to bedside, (iii) bedside to clinical applications (clinical trials), (iv) translation to policy and health care guidelines, (v) assessment of health policy and usage, and (vi) global health. All areas of medical research, including — but not restricted to — molecular biology, genetics, pharmacology, imaging and epidemiology are welcome as they contribute to enhance the field of translational psychiatry.
有限的翻译渠道给精神病学带来了巨大的损失。诺贝尔奖得主Julius Axelrod在1961年发现突触前神经元重摄取单胺，这一发现至今仍是当代抗抑郁治疗的基础。在神经科学知识的爆炸式增长和为我们的病人提供概念上的新疗法之间存在着严重的差距。转化精神病学通过促进和强调从发现到临床应用、医疗保健和全球健康的途径来弥合这一差距。我们将翻译广泛地视为从发现到全球健康的全方位工作。转化精神病学范围内的转化步骤包括（i）基础发现，（ii）从实验室到床边，（iii）从床边到临床应用（临床试验），（iv）转化为政策和卫生保健指南，（v）评估卫生政策和使用，以及（vi）全球卫生。欢迎所有医学研究领域，包括但不限于分子生物学、遗传学、药理学、成像和流行病学，因为它们有助于加强转化精神病学领域。
Efficacy of omega-3 PUFAs in depression: A meta-analysis
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0515-5
Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0525-3
Mechanisms and treatment of late-life depression
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0514-6
Psychobiological factors of resilience and depression in late life
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0424-7
Endogenous dopamine release under transcranial direct-current stimulation governs enhanced attention: a study with positron emission tomography
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0443-4
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0599-y
A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0470-1
A validation of the diathesis-stress model for depression in Generation Scotland
来源期刊：Translational PsychiatryDOI：10.1038/s41398-018-0356-7
Region specific knockdown of Parvalbumin or Somatostatin produces neuronal and behavioral deficits consistent with those observed in schizophrenia
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0603-6
Motor cortex excitability and inhibitory imbalance in autism spectrum disorder assessed with transcranial magnetic stimulation: a systematic review
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0444-3
Oxytocin receptors in the dorsolateral bed nucleus of the stria terminalis (BNST) bias fear learning toward temporally predictable cued fear
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0474-x
Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0593-4
Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0449-y
Recommendations and future directions for supervised machine learning in psychiatry
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0607-2
Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0482-x
Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stress
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0605-4
The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0675-3
Predicting rehospitalization within 2 years of initial patient admission for a major depressive episode: a multimodal machine learning approach
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0615-2
Resting-state functional connectivity in women with PMDD
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0670-8
iPSC model of CHRFAM7A effect on α7 nicotinic acetylcholine receptor function in the human context
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0375-z
Glucocorticoid-induced leucine zipper “quantifies” stressors and increases male susceptibility to PTSD
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0509-3
BDNF genetic variants and methylation: effects on cognition in major depressive disorder
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0601-8
Treatment response classes in major depressive disorder identified by model-based clustering and validated by clinical prediction models
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0524-4
NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0564-9
Correction: Altered gut metabolome contributes to depression-like behaviors in rats exposed to chronic unpredictable mild stress
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0645-9
Childhood stress impairs social function through AVP-dependent mechanisms
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0678-0
Genetic risk scores for major psychiatric disorders and the risk of postpartum psychiatric disorders
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0629-9
Acute anxiety and autonomic arousal induced by CO2 inhalation impairs prefrontal executive functions in healthy humans
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0634-z
Investigating the association between body fat and depression via Mendelian randomization
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0516-4
Depression and suicide risk prediction models using blood-derived multi-omics data
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0595-2
Leveraging brain cortex-derived molecular data to elucidate epigenetic and transcriptomic drivers of complex traits and disease
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0437-2
Role of the dorsal periaqueductal gray in posttraumatic stress disorder: mediation by dopamine and neurokinin
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0565-8
Risk gene-set and pathways in 22q11.2 deletion-related schizophrenia: a genealogical molecular approach
来源期刊：Translational PsychiatryDOI：10.1038/s41398-018-0354-9
Gene network analysis reveals a role for striatal glutamatergic receptors in dysregulated risk-assessment behavior of autism mouse models
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0584-5
Identification of HIVEP2 as a dopaminergic transcription factor related to substance use disorders in rats and humans
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0573-8
A computationally inspired in-vivo approach identifies a link between amygdalar transcriptional heterogeneity, socialization and anxiety
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0677-1
Functional connectivity underlying hedonic response to food in female adolescents with atypical AN: the role of somatosensory and salience networks
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0617-0
DLPFC transcriptome defines two molecular subtypes of schizophrenia
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0472-z
Depression genetic risk score is associated with anhedonia-related markers across units of analysis
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0566-7
Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0637-9
Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0523-5
Methylation-related metabolic effects of D4 dopamine receptor expression and activation
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0630-3
Desipramine restores the alterations in circadian entrainment induced by prenatal exposure to glucocorticoids
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0594-3
The Cunningham Panel: concerns remain
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0562-y
Correction: Temporal dynamics of miRNAs in human DLPFC and its association with miRNA dysregulation in schizophrenia
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0572-9
Clinical and genetic validity of quantitative bipolarity
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0561-z
Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0613-4
Correction: Regulation of dopaminergic function: An [18F]-DOPA PET apomorphine challenge study in humans
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0501-y
Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0674-4
Correction: Alzheimer’s disease polygenic risk score as a predictor of conversion from mild-cognitive impairment
来源期刊：Translational PsychiatryDOI：10.1038/s41398-019-0503-9
