Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents.Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research.The journal’s focus includes current developments in: Enzymology;Cell biology;Chemical biology;Microbiology;Physiology;Pharmacology leading to drug design;Molecular recognition processes;Distribution and metabolism of biologically active compounds.
《酶抑制与药物化学杂志》发表关于酶抑制剂、抑制过程以及药物和抗癌剂开发中激动剂/拮抗剂受体相互作用的开放存取研究。《酶抑制与药物化学杂志》旨在为酶抑制研究的最新发现提供一个国际和跨学科的平台。该杂志的重点包括以下方面的最新进展：酶学;细胞生物学;化学生物学;微生物学;生理学;药理学导致药物设计;分子识别过程生物活性化合物的分布和代谢。
Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure–activity relationship
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1558221
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1571271
Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1518958
Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1571055
In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1613390
Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1571273
Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1612889
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1581184
Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1630616
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1530223
Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1540474
Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1596086
Osteopontin – a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1587418
Sesquiterpenoids and 2-(2-phenylethyl)chromones respectively acting as α-glucosidase and tyrosinase inhibitors from agarwood of an Aquilaria plant
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1576657
Phosphonate inhibitors of West Nile virus NS2B/NS3 protease
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1506772
1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1636235
Design and application of oral colon administration system
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1655406
Novel 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives as potent and selective aldose reductase inhibitors with antioxidant activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1643336
Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1579805
Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1507029
Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1584622
Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1564045
Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1642883
Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1644329
In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1593159
Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1533822
Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1634703
Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1618292
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1596903
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1574779
Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1520228
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1575372
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1584620
Synthesis and biological evaluation of 3–(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer’s disease agents
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1615484
Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1585835
Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1653292
Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1557653
In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1575825
Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1651723
Blocking the FKBP12 induced dendrimeric burst in aberrant aggregation of α-synuclein by using the ElteN378 synthetic inhibitor
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1667342
A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1651312
Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1629432
Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1664499
Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1636234
Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1659790
Delivering bioactive cyclic peptides that target Hsp90 as prodrugs
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1580276
Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1612887
Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1651722
Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1634704
The protective role of jervine against radiation-induced gastrointestinal toxicity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1586681
