Journal of Enzyme Inhibition and Medicinal Chemistry publishes open access research on enzyme inhibitors, inhibitory processes, and agonist/antagonist receptor interactions in the development of medicinal and anti-cancer agents. Journal of Enzyme Inhibition and Medicinal Chemistry aims to provide an international and interdisciplinary platform for the latest findings in enzyme inhibition research. The journal’s focus includes current developments in: Enzymology; Cell biology; Chemical biology; Microbiology; Physiology; Pharmacology leading to drug design; Molecular recognition processes; Distribution and metabolism of biologically active compounds.
《酶抑制与药物化学杂志》发表关于酶抑制剂、抑制过程以及药物和抗癌剂开发中激动剂/拮抗剂受体相互作用的开放存取研究。《酶抑制与药物化学杂志》旨在为酶抑制研究的最新发现提供一个国际和跨学科的平台。该杂志的重点包括以下方面的最新进展：酶学;细胞生物学;化学生物学;微生物学;生理学;药理学导致药物设计;分子识别过程生物活性化合物的分布和代谢。
Evaluation of a flavonoids library for inhibition of pancreatic α-amylase towards a structure–activity relationship
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1558221
Computationally driven discovery of phenyl(piperazin-1-yl)methanone derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1571271
Synthesis and biological evaluation of 3-arylcoumarin derivatives as potential anti-diabetic agents
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1518958
Design and synthesis of 4-piperazinyl quinoline derived urea/thioureas for anti-breast cancer activity by a hybrid pharmacophore approach
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1571055
In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1613390
Inhibition of α-, β-, γ-, δ-, ζ- and η-class carbonic anhydrases from bacteria, fungi, algae, diatoms and protozoans with famotidine
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1571273
Design, synthesis, molecular modelling, and biological evaluation of novel substituted pyrimidine derivatives as potential anticancer agents for hepatocellular carcinoma
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1612889
New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1581184
Activation of human α-carbonic anhydrase isoforms I, II, IV and VII with bis-histamine schiff bases and bis-spinaceamine substituted derivatives
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1630616
Computer-aided molecular design of pyrazolotriazines targeting glycogen synthase kinase 3
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1530223
Repurposing existing drugs: identification of irreversible IMPDH inhibitors by high-throughput screening
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1540474
Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1596086
Osteopontin – a biomarker of disease, but also of stage stratification of the functional myocardial contractile deficit by chronic ischaemic heart disease
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1587418
Sesquiterpenoids and 2-(2-phenylethyl)chromones respectively acting as α-glucosidase and tyrosinase inhibitors from agarwood of an Aquilaria plant
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1576657
Phosphonate inhibitors of West Nile virus NS2B/NS3 protease
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1506772
1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1636235
Design and application of oral colon administration system
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1655406
Novel 2-phenoxypyrido[3,2-b]pyrazin-3(4H)-one derivatives as potent and selective aldose reductase inhibitors with antioxidant activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1643336
Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1579805
Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1507029
Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1584622
Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1564045
Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1642883
Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1644329
In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1593159
Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1533822
Dual-target anti-Alzheimer’s disease agents with both iron ion chelating and monoamine oxidase-B inhibitory activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1634703
Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1618292
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1596903
Chemically stable inhibitors of 14-3-3 protein–protein interactions derived from BV02
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1574779
Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1520228
Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1575372
Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1584620
Synthesis and biological evaluation of 3–(4-aminophenyl)-coumarin derivatives as potential anti-Alzheimer’s disease agents
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1615484
Novel Re(I) tricarbonyl coordination compounds based on 2-pyridyl-1,2,3-triazole derivatives bearing a 4-amino-substituted benzenesulfonamide arm: synthesis, crystal structure, computational studies and inhibitory activity against carbonic anhydrase I, II, and IX isoforms†
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1585835
Design, synthesis, in vitro potent antiproliferative activity, and kinase inhibitory effects of new triarylpyrazole derivatives possessing different heterocycle terminal moieties
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1653292
Inhibition of protein phosphatase-1 and -2A by ellagitannins: structure-inhibitory potency relationships and influences on cellular systems
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2018.1557653
In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1575825
Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1651723
Blocking the FKBP12 induced dendrimeric burst in aberrant aggregation of α-synuclein by using the ElteN378 synthetic inhibitor
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1667342
A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1651312
Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1629432
Synthesis and in vitro and in vivo anti-inflammatory activity of novel 4-ferrocenylchroman-2-one derivatives
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1664499
Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1636234
Synthesis and bioevaluation of novel steroidal isatin conjugates derived from epiandrosterone/androsterone
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1659790
Delivering bioactive cyclic peptides that target Hsp90 as prodrugs
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1580276
Stereoselective pharmacokinetic and pharmacodynamic analysis of a CNS-active sulphamoylphenyl carbamate derivative
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1612887
Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1651722
Discovery of aminopyridine-containing spiro derivatives as EGFR mutations inhibitors
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1634704
The protective role of jervine against radiation-induced gastrointestinal toxicity
来源期刊：Journal of Enzyme Inhibition and Medicinal ChemistryDOI：10.1080/14756366.2019.1586681
