The JCI reaches readers across a wide range of medical disciplines and sectors. The journal publishes basic and phase I/II clinical research submissions in all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others.
JCI的读者涵盖了广泛的医学学科和部门。该杂志发表所有生物医学专业的基础和I/II期临床研究论文，包括自身免疫学、胃肠病学、免疫学、代谢学、肾脏学、神经科学、肿瘤学、肺病学、血管生物学等。
Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124291
Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124466
Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123069
STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI121842
Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI97482
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI121561
Hepatic hepcidin/intestinal HIF-2&agr; axis maintains iron absorption during iron deficiency and overload
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122359
Epithelial barrier repair and prevention of allergy
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124608
Targeting FOXA1-mediated repression of TGF-&bgr; signaling suppresses castration-resistant prostate cancer progression
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122367
Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122085
Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124194
CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI99751
Splicing factor SRSF1 promotes gliomagenesis via oncogenic splice-switching of MYO1B
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI120279
Bronchus-associated lymphoid tissue–resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122083
c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122440
Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI98230
Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123375
Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123931
Circulating heparan sulfate fragments mediate septic cognitive dysfunction
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124485
PI3K p110&dgr; inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI99386
Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI121004
PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123743
Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI120816
Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123267
Targeting compensatory MEK/ERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI98785
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI121372
In vivo hematopoietic stem cell gene therapy ameliorates murine thalassemia intermedia
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122836
Gene fitness landscape of group A streptococcus during necrotizing myositis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124994
Bone marrow transplantation generates T cell–dependent control of myeloma in mice
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI98888
Bacterial sepsis triggers an antiviral response that causes translation shutdown
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123284
Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin &bgr;1
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122779
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI98554
Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI98869
Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122110
Podocyte histone deacetylase activity regulates murine and human glomerular diseases
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124030
Lipin 2/3 phosphatidic acid phosphatases maintain phospholipid homeostasis to regulate chylomicron synthesis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI122595
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI121987
Endothelial miR-30c suppresses tumor growth via inhibition of TGF-&bgr;–induced Serpine1
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123106
Mixing old and young: enhancing rejuvenation and accelerating aging
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123946
Cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI120110
Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI123233
Effective NY-ESO-1–specific MHC II–restricted T cell receptors from antigen-negative hosts enhance tumor regression
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI120391
Follicular lymphoma–associated mutations in vacuolar ATPase ATP6V1B2 activate autophagic flux and mTOR
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI98288
Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI99699
ARHGEF1 deficiency reveals G&agr;13-associated GPCRs are critical regulators of human lymphocyte function
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI125893
Not just correlative: a new pathway defines how an ALDH2 SNP contributes to atherosclerosis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI125433
Human T cell repertoire: what happens in thymus does not stay in thymus.
来源期刊：The Journal of clinical investigationDOI：10.1172/JCI128371
An adapted anti-CTLA4 therapeutic aimed at mitigating the toxicities of checkpoint inhibition
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI125800
Rejuvenation of &bgr; cells by epigenetic editing
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI124583
Fitness genes of group A streptococci in necrotizing fasciitis and myositis
来源期刊：Journal of Clinical InvestigationDOI：10.1172/JCI126482
