The Journal of Clinical Immunology publishes high impact papers in the area of human immunology that explore the diagnosis, pathogenesis, prognosis, or treatment of human diseases. The Journal is particularly focused on primary immunodeficiencies and related diseases. These include inborn errors of immunity, in the broad sense of the term, their underlying genotypes and their diverse phenotypes, including infection, malignancy, allergy, auto-inflammation, and autoimmunity. We consider a wide range of studies in this area, ranging from genetic discovery, clinical description, immunologic assessment, diagnostic approach, prognosis evaluation, and treatment intervention. Case reports are considered if they are truly original and are accompanied by a succinct review of the relevant medical literature and how the novel case study advances the field. The four categories of papers are detailed in the instructions to authors.
《临床免疫学杂志》发表人类免疫学领域的高影响力论文，探讨人类疾病的诊断、发病机制、预后或治疗。该杂志特别关注原发性免疫缺陷和相关疾病。这些包括先天性免疫缺陷，在广义上，它们的潜在基因型和它们的多样性表型，包括感染、恶性肿瘤、变态反应、自身炎症和自身免疫。我们考虑了这一领域的广泛研究，包括遗传发现、临床描述、免疫学评估、诊断方法、预后评估和治疗干预。如果病例报告是真正原创的，并附有相关医学文献的简明综述以及新病例研究如何推进该领域，则应予以考虑。四类论文详见作者须知。
Regulatory T Cells: the Many Faces of Foxp3
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00684-7
Efficacy and Adverse Events During Janus Kinase Inhibitor Treatment of SAVI Syndrome
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00645-0
Diagnostic Yield of Next Generation Sequencing in Genetically Undiagnosed Patients with Primary Immunodeficiencies: a Systematic Review
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00656-x
WHIM Syndrome: from Pathogenesis Towards Personalized Medicine and Cure
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00665-w
Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide for Primary Immune Deficiency Disorders in Children: Challenges and Outcome from a Tertiary Care Center in South India
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00600-z
Auto-inflammation in a Patient with a Novel Homozygous OTULIN Mutation
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00599-3
Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD—the Goldilocks’ Effect
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00612-9
A Novel CARMIL2 Mutation Resulting in Combined Immunodeficiency Manifesting with Dermatitis, Fungal, and Viral Skin Infections As Well as Selective Antibody Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00628-1
Chronic Granulomatous Disease-Associated IBD Resolves and Does Not Adversely Impact Survival Following Allogeneic HCT
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00659-8
Ficolin-3 Deficiency Is Associated with Disease and an Increased Risk of Systemic Lupus Erythematosus
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00627-2
Fifteen Years of the J Project
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00633-4
Health-Related Quality of Life and Emotional Difficulties in Chronic Granulomatous Disease: Data on Adult and Pediatric Patients from Italian Network for Primary Immunodeficiency (IPINet)
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00725-1
Interstitial Lung Disease Frequently Precedes CVID Diagnosis
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00708-2
A New Patient with Inherited TYK2 Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00713-5
Defining Primary Selective IgM Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00641-4
Altered Peripheral Blood Leucocyte Phenotype and Responses in Healthy Individuals with Homozygous Deletion of FHR1 and FHR3 Genes
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00619-2
MiR-608 Exerts Anti-inflammatory Effects by Targeting ELANE in Monocytes
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00702-8
Mutual alteration of NOD2-associated Blau syndrome and IFNγR1 deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00720-6
NAPDH Oxidase-Specific Flow Cytometry Allows for Rapid Genetic Triage and Classification of Novel Variants in Chronic Granulomatous Disease
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00712-6
Novel Exonic Deletions in TTC7A in a Newborn with Multiple Intestinal Atresia and Combined Immunodeficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00669-6
A De Novo Frameshift Mutation in TNFAIP3 Impairs A20 Deubiquitination Function to Cause Neuropsychiatric Systemic Lupus Erythematosus
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00695-4
Expanding Clinical Phenotype and Novel Insights into the Pathogenesis of ICOS Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00735-z
Should MASP-2 Deficiency Be Considered a Primary Immunodeficiency? Relevance of the Lectin Pathway
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00714-4
Recurrent Salmonella typhi Infection and Autoimmunity in a Young Boy with Complete IL-12 Receptor β1 Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00637-0
STK4 Deficiency in a Patient with Immune Complex Glomerulonephritis, Salt-Losing Tubulopathy, and Castleman’s-Like Disease
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00682-9
Successful Rituximab Treatment for Lymphoma, Secondary Immunodeficiency Causing Debilitating Sinusitis: Underlying Primary Immunodeficiency Disease, and Alternative Treatments to Improve the Quality of Life?
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00636-1
A Novel FOXN1 Variant Is Identified in Two Siblings with Nude Severe Combined Immunodeficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00615-6
Health-Related Quality of Life and Emotional Health in X-Linked Carriers of Chronic Granulomatous Disease in the United Kingdom
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00607-6
Compound Heterozygous DOCK8 Mutations in a Patient with B Lymphoblastic Leukemia and EBV-Associated Diffuse Large B Cell Lymphoma
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00663-y
Neurological Involvement in Childhood Evans Syndrome
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-0594-3
The Value of Chromosome Analysis to Interrogate Variants in DNMT3B Causing Immunodeficiency, Centromeric Instability, and Facial Anomaly Syndrome Type I (ICF1)
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00704-6
Altered Monocyte Subsets in Patients with Chronic Idiopathic Neutropenia
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00694-5
BCG Moreau Vaccine Safety Profile and NK Cells—Double Protection Against Disseminated BCG Infection in Retrospective Study of BCG Vaccination in 52 Polish Children with Severe Combined Immunodeficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00709-1
Compound Heterozygous PGM3 Mutations in a Thai Patient with a Specific Antibody Deficiency Requiring Monthly IVIG Infusions
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00693-6
Current Status of the Management of Mendelian Susceptibility to Mycobacterial Disease in Mainland China
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00672-x
Severe Transitory Neonatal Neutropenia Associated with Maternal Autoimmune or Idiopathic Neutropenia
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00608-5
A Large Cohort of RAG1/2-Deficient SCID Patients—Clinical, Immunological, and Prognostic Analysis
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00717-1
Successful Lung Transplantation in a Patient with Chronic Granulomatous Disease
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00623-6
Novel Missense Mutation inSP110Associated with Combined Immunodeficiency and Advanced Liver Disease Without VOD
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00715-3
Provider Perceptions of Quality of Life, Neurocognition, Physical Well-being, and Psychosocial Health in Patients with Primary Immunodeficiency/Immune Dysregulation Conditions
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00703-7
Successful Treatment of a Patient with Chronic Systemic Capillary Leak Syndrome, Neutropenia and Thymoma
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00722-4
Autoinflammation with Infantile Enterocolitis Associated with Recurrent Perianal Abscesses
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00611-w
Autoinflammation Masquerading as Autoimmunity in an Adult with Heterozygous p.E250K PSTPIP1 Mutation
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00646-z
RNAseq Supports the Molecular Genetic Diagnosis of Late-Onset ADA Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00625-4
Serum Tryptase Cannot Differentiate Vancomycin-Induced Anaphylaxis From Red Man Syndrome
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00707-3
The Broad Clinical Spectrum and Transplant Results of PNP Deficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00698-1
A 1-Year Prospective French Nationwide Study of Emergency Hospital Admissions in Children and Adults with Primary Immunodeficiency
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00658-9
Disseminated Mycobacterial Disease in a Patient with 22q11.2 Deletion Syndrome: Case Report and Review of the Literature
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00678-5
Autoimmune Lymphoproliferative Syndrome with Cryptococcus Infection
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00676-7
RNASEH2B Related Adult-Onset Interferonopathy
来源期刊：Journal of Clinical ImmunologyDOI：10.1007/s10875-019-00673-w
