Current Opinion in Structural Biology (COSB) aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed.In COSB, we help the reader by providing in a systematic manner:1. The views of experts on current advances in their field in a clear and readable form.2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...]The subject of Structural Biology is divided into twelve themed sections, each of which is reviewed once a year. Each issue contains two sections, and the amount of space devoted to each section is related to its importance.-Folding and Binding-Nucleic acids and their protein complexes-Macromolecular Machines-Theory and Simulation-Sequences and Topology-New constructs and expression of proteins-Membranes-Engineering and Design-Carbohydrate-protein interactions and glycosylation-Biophysical and molecular biological methods-Multi-protein assemblies in signalling-Catalysis and Regulation
当前结构生物学观点（COSB）旨在激发基于科学的、跨学科的、多尺度的辩论和思想交流。它包含精炼、简洁和及时的评论和意见，特别强调过去两年发表的那些文章。除了描述最新的趋势，作者被鼓励给予他们对所讨论主题的主观意见。在COSB中，我们以系统的方式提供帮助读者：1.专家的意见，目前的进展，在他们的领域在一个清晰和可读的形式。2.对最有趣的论文的评价，由专家注释，从原始出版物的巨大财富。[...]结构生物学分为十二个主题部分，每个部分每年复习一次。每期包含两个部分，每个部分的篇幅与其重要性有关。折叠与结合-核酸及其蛋白质复合物-高分子机械-理论与模拟-序列与拓扑-蛋白质的新构建与表达-膜-工程与设计-糖-蛋白质相互作用与糖基化-生物物理与分子生物学方法-信号转导中的多蛋白质组装体-催化与调控
Evolving SAXS versatility: solution X-ray scattering for macromolecular architecture, functional landscapes, and integrative structural biology
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.04.004
The tetratricopeptide-repeat motif is a versatile platform that enables diverse modes of molecular recognition.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2018.12.004
First-generation predictors of biological protein phase separation.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.05.016
What method to use for protein-protein docking?
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2018.12.010
Polysaccharide degradation by lytic polysaccharide monooxygenases.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.015
Amyloid structures: much more than just a cross-β fold.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.09.001
Advances in cryo-electron tomography and subtomogram averaging and classification
来源期刊：Current Opinion in Structural BiologyDOI：10.1016/j.sbi.2019.05.021
Bacteriophytochromes - from informative model systems of phytochrome function to powerful tools in cell biology.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.005
The role of NMR spectroscopy in mapping the conformational landscape of GPCRs.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.030
Glycan structures and their interactions with proteins. A NMR view
来源期刊：Current Opinion in Structural BiologyDOI：10.1016/j.sbi.2019.11.004
Dissecting diverse functions of NMDA receptors by structural biology.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2018.12.009
Importance of protein dynamics in the structure-based drug discovery of class A G protein-coupled receptors (GPCRs).
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.015
The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.002
Structure and mechanism of AMPA receptor - auxiliary protein complexes.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.01.011
Structural and mechanistic elucidation of inflammasome signaling by cryo-EM.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.033
Optogenetic approaches to study the mammalian brain.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.04.003
The role of circular dichroism spectroscopy in the era of integrative structural biology.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.04.001
Rational design of genetically encoded singlet oxygen photosensitizing proteins.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.01.025
Charging the code - tRNA modification complexes.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.014
Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.06.005
Modelling structures in cryo-EM maps.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.05.024
The pre-synaptic fusion machinery
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.007
Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.05.022
Peptidyl arginine deiminases: detection and functional analysis of protein citrullination.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.01.024
Molecular architecture of the presynaptic terminal.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.01.008
The role of coevolutionary signatures in protein interaction dynamics, complex inference, molecular recognition, and mutational landscapes.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.024
Advances toward mapping the full extent of protein site-specific O-GalNAc glycosylation that better reflects underlying glycomic complexity.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.007
Elucidating ligand-bound structures of membrane proteins using solid-state NMR spectroscopy.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.002
New metal cofactors and recent metallocofactor insights.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2018.12.008
Nucleocytoplasmic O-glycosylation in protists.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.031
Regulatory mechanisms in postsynaptic phosphorylation networks.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.01.003
Current status of multiscale simulations on GPCRs.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.013
Intrinsic protein disorder and protein modifications in the processing of biological signals.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.09.003
Current approaches for the analysis of spindle organization.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.05.023
Structure and engineering of tandem repeat lectins.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.11.006
Mass spectrometry analysis of the structural proteome.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.10.006
Jump ahead with a twist: DNA acrobatics drive transposition forward
来源期刊：Current Opinion in Structural BiologyDOI：10.1016/j.sbi.2019.08.006
Structural and mechanistic insight from antiviral and antiparasitic enzyme drug targets for tropical infectious diseases.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.014
Multiscale simulations on human Frizzled and Taste2 GPCRs.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.02.009
Structural and mechanistic themes in glycoconjugate biosynthesis at membrane interfaces.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.013
Bilin-metabolizing enzymes: site-specific reductions catalyzed by two different type of enzymes.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.03.005
Shanks - multidomain molecular scaffolds of the postsynaptic density.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.01.007
Interpretation of medium resolution cryoEM maps of multi-protein complexes
来源期刊：Current Opinion in Structural BiologyDOI：10.1016/j.sbi.2019.06.009
Challenges and opportunities in cryo-EM with phase plate.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.06.013
Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.05.007
Porous crystals as scaffolds for structural biology.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.12.008
Expanding single-molecule fluorescence spectroscopy to capture complexity in biology.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.05.005
Recent advances in understanding bacterial and archaeoeukaryotic primases.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.08.004
Dcp2: an mRNA decapping enzyme that adopts many different shapes and forms
来源期刊：Current Opinion in Structural BiologyDOI：10.1016/j.sbi.2019.07.009
RNA lifetime control, from stereochemistry to gene expression.
来源期刊：Current opinion in structural biologyDOI：10.1016/j.sbi.2019.10.002
