Launched in 1995, Genome Research is an international, continuously published, peer-reviewed journal that focuses on research that provides novel insights into the genome biology of all organisms, including advances in genomic medicine.Among the topics considered by the journal are genome structure and function, comparative genomics, molecular evolution, genome-scale quantitative and population genetics, proteomics, epigenomics, and systems biology. The journal also features exciting gene discoveries and reports of cutting-edge computational biology and high-throughput methodologies.New data in these areas are published as research papers, or methods and resource reports that provide novel information on technologies or tools that will be of interest to a broad readership. Complete data sets are presented electronically on the journal's web site where appropriate. The journal also provides Reviews, Perspectives, and Insight/Outlook articles, which present commentary on the latest advances published both here and elsewhere, placing such progress in its broader biological context.
《基因组研究》是一份国际性的、持续出版的、同行评审的期刊，主要关注对所有生物体的基因组生物学提供新见解的研究，包括基因组医学的进展。该期刊讨论的主题包括基因组结构和功能、比较基因组学、分子进化、基因组规模的定量和群体遗传学、蛋白质组学、表观基因组学和系统生物学。该杂志还刊登了令人兴奋的基因发现以及前沿计算生物学和高通量方法学的报告。这些领域的新数据以研究论文或方法和资源报告的形式发表，提供了广泛读者感兴趣的技术或工具的新信息。完整的数据集在适当的情况下以电子方式在期刊网站上提供。该杂志还提供评论、观点和洞察/展望文章，对在这里和其他地方发表的最新进展进行评论，将这些进展置于更广泛的生物学背景下。
Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis.
来源期刊：Genome researchDOI：10.1101/gr.247064.118
Structural variants in 3000 rice genomes.
来源期刊：Genome researchDOI：10.1101/gr.241240.118
Comprehensive, integrated, and phased whole-genome analysis of the primary ENCODE cell line K562.
来源期刊：Genome researchDOI：10.1101/gr.234948.118
A chromosome-scale assembly of the axolotl genome.
来源期刊：Genome researchDOI：10.1101/gr.241901.118
The origins and evolution of chromosomes, dosage compensation, and mechanisms underlying venom regulation in snakes.
来源期刊：Genome researchDOI：10.1101/gr.240952.118
A quantitative framework for characterizing the evolutionary history of mammalian gene expression.
来源期刊：Genome researchDOI：10.1101/gr.237636.118
Transcription factor activity and nucleosome organization in mitosis.
来源期刊：Genome researchDOI：10.1101/gr.243048.118
Decrypting noncoding RNA interactions, structures, and functional networks.
来源期刊：Genome researchDOI：10.1101/gr.247239.118
Anchor: trans-cell type prediction of transcription factor binding sites.
来源期刊：Genome researchDOI：10.1101/gr.237156.118
Ancient exapted transposable elements promote nuclear enrichment of human long noncoding RNAs.
来源期刊：Genome researchDOI：10.1101/gr.229922.117
Coexpression patterns define epigenetic regulators associated with neurological dysfunction.
来源期刊：Genome researchDOI：10.1101/gr.239442.118
Hormone-control regions mediate steroid receptor-dependent genome organization.
来源期刊：Genome researchDOI：10.1101/gr.243824.118
Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans.
来源期刊：Genome researchDOI：10.1101/gr.242453.118
TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.
来源期刊：Genome researchDOI：10.1101/gr.239277.118
Defining TP53 pioneering capabilities with competitive nucleosome binding assays.
来源期刊：Genome researchDOI：10.1101/gr.234104.117
Whole-genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes.
来源期刊：Genome researchDOI：10.1101/gr.245795.118
Histone methyltransferase PRDM9 is not essential for meiosis in male mice.
来源期刊：Genome researchDOI：10.1101/gr.244426.118
SiCloneFit: Bayesian inference of population structure, genotype, and phylogeny of tumor clones from single-cell genome sequencing data
来源期刊：Genome ResearchDOI：10.1101/gr.243121.118
OMA standalone: orthology inference among public and custom genomes and transcriptomes.
来源期刊：Genome researchDOI：10.1101/gr.243212.118
Long-read single-molecule maps of the functional methylome.
来源期刊：Genome researchDOI：10.1101/gr.240739.118
Targeted delivery of CRISPR interference system against Fabp4 to white adipocytes ameliorates obesity, inflammation, hepatic steatosis, and insulin resistance.
来源期刊：Genome researchDOI：10.1101/gr.246900.118
Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification.
来源期刊：Genome researchDOI：10.1101/gr.249680.119
Differences in firing efficiency, chromatin, and transcription underlie the developmental plasticity of the Arabidopsis DNA replication origins.
来源期刊：Genome researchDOI：10.1101/gr.240986.118
Contrasting roles of the RSC and ISW1/CHD1 chromatin remodelers in RNA polymerase II elongation and termination.
来源期刊：Genome researchDOI：10.1101/gr.242032.118
Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns.
来源期刊：Genome researchDOI：10.1101/gr.242164.118
Mapping global and local coevolution across 600 species to identify novel homologous recombination repair genes.
来源期刊：Genome researchDOI：10.1101/gr.241414.118
4q-D4Z4 chromatin architecture regulates the transcription of muscle atrophic genes in facioscapulohumeral muscular dystrophy.
来源期刊：Genome researchDOI：10.1101/gr.233288.117
Brown rat demography reveals pre-commensal structure in eastern Asia before expansion into Southeast Asia.
来源期刊：Genome researchDOI：10.1101/gr.235754.118
Identifying loci under positive selection in complex population histories.
来源期刊：Genome researchDOI：10.1101/gr.246777.118
Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity in Drosophila.
来源期刊：Genome researchDOI：10.1101/gr.243832.118
Genome-wide analysis of polymerase III-transcribed Alu elements suggests cell-type-specific enhancer function.
来源期刊：Genome researchDOI：10.1101/gr.249789.119
A machine-learning approach for accurate detection of copy-number variants from exome sequencing.
来源期刊：Genome researchDOI：10.1101/gr.245928.118
High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma.
来源期刊：Genome researchDOI：10.1101/gr.246520.118
Dynamic reversal of random X-Chromosome inactivation during iPSC reprogramming.
来源期刊：Genome researchDOI：10.1101/gr.249706.119
A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS.
来源期刊：Genome researchDOI：10.1101/gr.243592.118
Identification of human silencers by correlating cross-tissue epigenetic profiles and gene expression.
来源期刊：Genome researchDOI：10.1101/gr.247007.118
Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation.
来源期刊：Genome researchDOI：10.1101/gr.250217.119
MicroRNAs reinforce repression of PRC2 transcriptional targets independently and through a feed-forward regulatory network.
来源期刊：Genome researchDOI：10.1101/gr.238311.118
Convergent recombination cessation between mating-type genes and centromeres in selfing anther-smut fungi.
来源期刊：Genome researchDOI：10.1101/gr.242578.118
Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features.
来源期刊：Genome researchDOI：10.1101/gr.245027.118
Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): a cloud-based platform for curating and classifying germline variants.
来源期刊：Genome researchDOI：10.1101/gr.250357.119
Transcriptional alterations in glioma result primarily from DNA methylation-independent mechanisms.
来源期刊：Genome researchDOI：10.1101/gr.249219.119
Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations.
来源期刊：Genome researchDOI：10.1101/gr.246884.118
Global analyses of the dynamics of mammalian microRNA metabolism
来源期刊：Genome ResearchDOI：10.1101/gr.251421.119
Environmentally induced plasticity of programmed DNA elimination boosts somatic variability in Paramecium tetraurelia.
来源期刊：Genome researchDOI：10.1101/gr.245332.118
A novel synthetic-genetic-array based yeast one-hybrid system for high discovery rate and short processing time.
来源期刊：Genome researchDOI：10.1101/gr.245951.118
Dynamics of microRNA expression during mouse prenatal development
来源期刊：Genome ResearchDOI：10.1101/gr.248997.119
Sequence determinants of polyadenylation-mediated regulation.
来源期刊：Genome researchDOI：10.1101/gr.247312.118
Genes essential for embryonic stem cells are associated with neurodevelopmental disorders
来源期刊：Genome ResearchDOI：10.1101/gr.250019.119
Fitness benefits of loss of heterozygosity in Saccharomyces hybrids.
来源期刊：Genome researchDOI：10.1101/gr.245605.118
