Experimental Hematology publishes new findings, methodologies, reviews and perspectives in all areas of hematology and immune cell formation on a monthly basis that may include Special Issues on particular topics of current interest. The overall goal is to report new insights into how normal blood cells are produced, how their production is normally regulated, mechanisms that contribute to hematological diseases and new approaches to their treatment. Specific topics may include relevant developmental and aging processes, stem cell biology, analyses of intrinsic and extrinsic regulatory mechanisms, in vitro behavior of primary cells, clonal tracking, molecular and omics analyses, metabolism, epigenetics, bioengineering approaches, studies in model organisms, novel clinical observations, transplantation biology and new therapeutic avenues.
实验血液学每月发表血液学和免疫细胞形成所有领域的新发现、方法、评论和观点，其中可能包括当前感兴趣的特定主题的特别问题。总体目标是报告对正常血细胞如何产生、其产生如何正常调节、导致血液病的机制及其治疗新方法的新见解。具体主题可能包括相关的发育和衰老过程、干细胞生物学、内在和外在调节机制分析、原代细胞的体外行为、克隆跟踪、分子和组学分析、代谢、表观遗传学、生物工程方法、模式生物研究、新的临床观察、移植生物学和新的治疗途径。
CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p-XIAP axis.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2018.10.011
Development of innate immune cells from human pluripotent stem cells.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2018.12.005
Deferasirox selectively induces cell death in the clinically relevant population of leukemic CD34+CD38- cells through iron chelation, induction of ROS, and inhibition of HIF1α expression.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2018.10.010
Eltrombopag promotes DNA repair in human hematopoietic stem and progenitor cells.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.03.002
Loss of EfnB1 in the osteogenic lineage compromises their capacity to support hematopoietic stem/progenitor cell maintenance.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2018.10.004
Human acute myeloid leukemia blast-derived exosomes in patient derived xenograft mice mediate immune suppression.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.07.005
Induced pluripotent stem cell modeling of malignant hematopoiesis.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.01.002
Glycolytic enzyme hexokinase II is a putative therapeutic target in B cell malignant lymphoma.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.09.023
Chronic graft-versus-host disease and the risk of primary disease relapse: A meta-analysis.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.04.004
Targeting cell-bound MUC1 on myelomonocytic, monocytic leukemias and phenotypically defined leukemic stem cells with anti-SEA module antibodies.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2018.12.002
ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.02.004
LOSS OF FBXO11 FUNCTIONS DRIVES ACUTE MYELOID LEUKEMIA
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.407
USP44 is dispensable for normal hematopoietic stem cell function, lymphocyte development, and B-cell-mediated immune response in a mouse model.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.01.001
Identification of miRNAs from stem cell derived microparticles in umbilical cord blood.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.11.001
Disease modeling of bone marrow failure syndromes using iPSC-derived hematopoietic stem progenitor cells.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.01.006
1030 - REGULATION OF HEMATOPOIETIC AND IMMUNE ESCAPE OF AML STEM CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.268
2001 - LONG-TERM EX VIVO EXPANSION OF FUNCTIONAL HEMATOPOIETIC STEM CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.276
STEM CELL LIKE ERYTHROID/MEGAKARYOCYTE-PRIMED PROGENITORS EXPAND IN HUMANS IN RESPONSE TO FREQUENT PLATELET DONATION
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.318
1008 - CHANGING NEIGHBOURS: BONE MARROW REMODELLING DURING AGING AND AGE-RELATED MYELOPROLIFERATIVE DISORDERS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.246
Further assessment of stochastic proliferation and its potential application to hematopoietic scaling across species.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.11.003
DEVELOPMENT OF A DATA PORTAL FOR AGGREGATION AND ANALYSIS OF GENOMICS DATA IN FAMILIAL PLATELET DISORDER WITH PREDISPOSITION TO MYELOID MALIGNANCY – THE RUNX1.DB
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.369
CHARACTERIZATION OF THERAPY-INSENSITIVE LSC SUBPOPULATIONS IN CHRONIC MYELOID LEUKEMIA
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.458
THE MECHANISM OF ONCOGENIC MUTATIONS IN THE JUXTAMEMBRANE AND TRANSMEMBRANE REGION OF IL7RA AND TPOR/MPL
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.332
Application of blood and immunodeficiency gene detection in the diagnosis of hemophagocytic lymphohistiocytosis patients.
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.09.024
2025 - RHEUMATOID ARTHRITIS INCREASES SYMPATHETIC NERVOUS SYSTEM DRIVEN HEMATOPOIETIC STEM CELL MOBILISATION AND ATHEROGENESIS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.297
FUNCTIONAL ANALYSIS OF CD99 UPREGULATION IN ACUTE MYELOID LEUKEMIA
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.322
2004 - NOVEL PRO-INFLAMMATORY AGM-ASSOCIATED MACROPHAGES ARE INVOLVED IN EMBRYONIC DEVELOPMENT OF HEMATOPOIETIC STEM CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.279
2007 - RIPPING LEUKEMIAS APART: THE ROLE OF RIP KINASE 1 IN ACUTE MYELOID LEUKEMIA
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.281
1022 - SYSTEMATIC GENETIC DISSECTION OF THE HEMATOPOIETIC STEM CELL NICHE IN THE FETAL LIVER
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.260
Metcalf Lecture Award Manuscript-Applying niche biology to engineer T cell regenerative therapies.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.11.004
2034 – RAB5C-MEDIATED ENDOCYTIC TRAFFICKING REGULATES HEMATOPOIETIC STEM AND PROGENITOR CELL DEVELOPMENT THROUGH NOTCH AND AKT SIGNALING
来源期刊：Experimental HematologyDOI：10.1016/j.exphem.2019.09.003
Lipocalin-2 levels in acute and chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
来源期刊：Experimental hematologyDOI：10.1016/j.exphem.2019.05.001
2028 - PULSATION IN BLOOD VESSELS STIMULATES MECHANOSENSITIVE AND EPIGENETIC MECHANISMS TO PROMOTE THE BIRTH OF HEMATOPOIETIC STEM CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.300
INTERLEUKIN-1 RESTRICTS HSC PROLIFERATION VIA A PU.1-DEPENDENT MECHANISM
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.420
2021 - CHOLINERGIC INFLUENCE OF BONE MARROW VASCULAR MICROENVIRONMENT INFLUENCES HEMATOPOIETIC STEM CELL MOBILIZATION
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.293
THE TRANSCRIPTION FACTOR IRF8 EPIGENETICALLY REGULATES EARLY DENDRITIC CELL SPECIFICATION
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.374
ARE THE BCL2 FAMILY INHIBITORS SUBSTRATES FOR THE MULTIDRUG RESISTANCE EFFLUX PUMP MDR1
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.408
REVERSIBILITY OF MIR-125A-INDUCED SELF-RENEWAL AND EXPANSION OF HEMATOPOIETIC STEM CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.401
COMBINED LENTIVIRAL- AND RNA-MEDIATED CRISPR/CAS9 DELIVERY FOR EFFICIENT AND TRACEABLE GENE EDITING IN HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.326
3166 – THE ROLE OF AUTOPHAGY IN HEMATOPOIESIS AND HEMATOPOIETIC DISEASE
来源期刊：Experimental HematologyDOI：10.1016/j.exphem.2019.09.008
2031 - DELINEATING MECHANISMS OF ACQUIRED RESISTANCE TO IDH INHIBITORS IN AML
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.303
1034 - EPIGENETIC REGULATION IN LEUKEMIAS: FROM BASIC BIOLOGY TO NEW THERAPIES
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.272
1003 - UNDERSTANDING AND TARGETING THE STEM CELL ORIGINS OF MYELOID MALIGNANCIES
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.241
2009 - DISRUPTING THE MASTER REGULATORS OF BLOOD EMERGENCE IN THE MOUSE EMBRYO
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.283
IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.411
MESENCHYMAL STEM CELLS SUPPRESS LEUKEMIA VIA MACROPHAGE-MEDIATED BONE MARROW NICHE RESTORATION
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.463
2000 - MONOLINEAGE ORIGIN OF RELAPSE FOLLOWING MULTILINEAGE DIFFERENTIATION THERAPY OF ACUTE MYELOID LEUKEMIA
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.275
DACH1 DOWNREGULATION DELINEATE A LYMPHOID PRIMED PROGENITOR (LPP) POPULATION WITHIN THE MPP4 CLUSTER
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.448
ENHANCED ENRICHMENT OF SMALL CD31+ BLAST-LIKE HUMAN CORD BLOOD CELLS
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.362
MECHANISM OF IMPROVED HUMAN HEMATOPOIETIC STEM CELL ENGRAFTMENT IN NON-CONDITIONED NSGW41 MICE
来源期刊：Experimental HematologyDOI：10.1016/J.EXPHEM.2019.06.425
