Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
药物开发研究专注于与新治疗实体的发现和开发相关的研究主题。该杂志发表药物化学、药理学、生物技术和生物制药、毒理学、药物输送、制剂和药代动力学方面的原创研究文章。该杂志欢迎在所有领域的新化合物和技术的手稿，重点是人类治疗，以及全球管理，卫生保健政策，和涉及药物发现和开发过程的监管问题。除了完整的文章，药物开发研究出版重要和及时的新研究结果的简要报告，以及深入的审查文章。该杂志还定期推出专门针对特定化合物类别、新技术以及药物发现和开发的广泛方面的专题问题。
Curcumin reduces inflammation in knee osteoarthritis rats through blocking TLR4 /MyD88/NF‐κB signal pathway
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21509
Mechanisms underlying isoliquiritigenin‐induced apoptosis and cell cycle arrest via ROS‐mediated MAPK/STAT3/NF‐κB pathways in human hepatocellular carcinoma cells
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21518
Can light‐based approaches overcome antimicrobial resistance?
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21453
Inhibiting conjugation as a tool in the fight against antibiotic resistance
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21457
Reaching toward underexplored targets in antibacterial drug design
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21465
Investigation of the antibacterial and antifungal activity of thiolated naphthoquinones
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21512
Microsponge: An emerging drug delivery strategy
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21492
Expression of Concern: Preventive effect of nerolidol on isoproterenol induced myocardial damage in Wistar rats: Evidences from biochemical and histopathological studies
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21564
Synthesis, in vivo and in silico evaluation of novel 2,3‐dihydroquinazolin‐4(1H)‐one derivatives as potential anticonvulsant agents
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21506
Synthesis, anticonvulsant screening, and molecular modeling studies of new arylalkylimidazole oxime ether derivatives
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21491
The use of aliskiren as an antifibrotic drug in experimental models: A systematic review
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21610
Dimethylaminoparthenolide reduces the incidence of dysplasia and ameliorates a wasting syndrome in HPV16‐transgenic mice
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21565
Cerebrolysin improves peripheral inflammatory pain: Sex differences in two models of acute and chronic mechanical hypersensitivity
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21528
Curcumin ameliorates experimental autoimmune encephalomyelitis in a C57BL/6 mouse model
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21540
8‐Hydroxyquinolines are bactericidal against Mycobacterium tuberculosis
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21531
Discovery of novel halogenated 8‐hydroxyquinoline‐based anti‐MRSA agents: In vitro and QSAR studies
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21611
Structure–activity study of fluorine or chlorine‐substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21515
Discovery of a new family of heterocyclic amine linked plastoquinone analogs for antimicrobial evaluation
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21591
Drug resistance in Mycobacterium tuberculosis and targeting the l,d‐transpeptidase enzyme
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21455
Neuroprotective effects of clavulanic acid following permanent bilateral common carotid artery occlusion in rats
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21595
Mucosal gene expression changes induced by anti‐TNF treatment in inflammatory bowel disease patients
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21566
Antiviral compound screening, peptide designing, and protein network construction of influenza a virus (strain a/Puerto Rico/8/1934 H1N1)
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21475
Folic acid‐conjugated raloxifene hydrochloride carbon nanotube for targeting breast cancer cells
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21620
Effectiveness of nalbuphine, a κ‐opioid receptor agonist and μ‐opioid receptor antagonist, in the inhibition of INa, IK(M), and IK(erg) unlinked to interaction with opioid receptors
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21568
iRGD‐paclitaxel conjugate nanoparticles for targeted paclitaxel delivery
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21589
Emerging role of primary heterogeneous nucleation in pharmaceutical crystallization
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21622
Schiff base‐nickel, palladium, and platinum complexes derived from N‐cyclohexyl hydrazine carbothioamide and 3‐hydroxy‐4‐methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21559
Spontaneous mutations conferring antibiotic resistance to antitubercular drugs at a range of concentrations in Mycobacterium smegmatis
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21497
Differential regulation of intestinal and hepatic CYP3A by 1α,25‐dihydroxyvitamin D3: Effects on in vivo oral absorption and disposition of buspirone in rats
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21505
Antiviral effects of a niobium‐substituted heteropolytungstate on hepatitis B virus‐transgenic mice
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21586
Aza‐CGP37157‐lipoic hybrids designed as novel Nrf2‐inducers and antioxidants exert neuroprotection against oxidative stress and show neuroinflammation inhibitory properties
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21618
Identification of two arylimides as cholinesterase inhibitors and testing of propranolol addition on impaired rat memory
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21633
Functional mechanism of tracheal relaxation, antiasthmatic, and toxicological studies of 6‐hydroxyflavone
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21484
Cristazine, a novel dioxopiperazine alkaloid, induces apoptosis via the death receptor pathway in A431 cells
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21527
A new potential anti‐cancer beta‐carboline derivative decreases the expression levels of key proteins involved in glioma aggressiveness: A proteomic investigation
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21600
Anti‐inflammatory effects of Vicenin‐2 on dextran sulfate sodium‐induced colitis in mice
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21529
Novel histone deacetylase inhibitors bearing a 4‐piperidin‐4‐yl‐triazole scaffold as antitumor agents
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21603
Synthesis, molecular modeling studies, ADME prediction of arachidonic acid carbamate derivatives, and evaluation of their acetylcholinesterase activity
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21621
Mechanism of penehyclidine hydrochloride on a dysmenorrhea rat model
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21500
Angiotensin II‐induced micro RNA‐21 culprit for non‐small‐cell lung adenocarcinoma
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21597
Optimization of pyrrolo[3,4‐f]indole‐5,7‐dione and indole‐5,6‐dicarbonitrile derivatives as inhibitors of monoamine oxidase
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21576
In vitro and in vivo evaluation of radiolabeled methyl N‐[5‐(3′‐halobenzoyl)‐1H‐benzimidazol‐2‐yl]carbamate for cancer radiotherapy
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21604
SCN11A mRNA levels in female bipolar disorder PBMCs as tentative biomarker for distinct patient sub‐phenotypes
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21598
Design and synthesis of 2‐hydroxyl‐4‐methoxyl‐3‐(3‐methylbut‐2‐en‐1‐yl)‐6‐(4‐phenylbenzoylamino)benzoic acid derivatives as antibacterial agents based on cajaninstilbene acid scaffold hopping
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21556
Synthesis and antimicrobial evaluation of piperic acid amides and their lower homologues
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21630
Graph theoretical analysis, in silico modeling, prediction of toxicity, metabolism and synthesis of novel 2‐(methyl/phenyl)‐3‐(4‐(5‐substituted‐1,3,4‐oxadiazol‐2‐yl) phenyl) quinazolin‐4(3H)‐ones as NMDA receptor inhibitor
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21511
Modified‐release oral pellets for duodenum delivery of doxycycline hyclate
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21575
Synthesis, evaluation, molecular docking, and molecular dynamics studies of novel N‐(4‐[pyridin‐2‐yloxy]benzyl)arylamine derivatives as potential antitubercular agents
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21623
Matching pH values for antibody stabilization and crystallization suggest rationale for accelerated development of biotherapeutic drugs
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21624
Synthesis, biological evaluation, and molecular modeling of nitrile‐containing compounds: Exploring multiple activities as anti‐Alzheimer agents
来源期刊：Drug Development ResearchDOI：10.1002/ddr.21594
