Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies.ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs.ContentsChemMedChem publishes an attractive mixture of:Full Papers and CommunicationsReviews and MinireviewsPatent ReviewsHighlights and ConceptsBook and Multimedia Reviews.
质量研究。杰出的出版物。《ChemMedChem》的影响因子为3.124（2019），是化学、生物学和医学界面研究的顶级期刊。它是代表欧洲化学协会（一个由16个欧洲化学学会组成的协会）出版的。ChemMedChem出版来自世界各地作者的初级以及关键的二级和三级信息。其使命是整合广泛而蓬勃发展的医学和制药科学领域，从药物设计和发现到药物开发和递送，从分子建模到组合化学，从靶标验证到先导化合物生成和ADMET研究。ChemMedChem主要涉及小分子、治疗性大分子、肽、肽模拟物、适体、蛋白质药物结合物、核酸治疗，以及2017年开始的纳米医学，特别是1）靶向纳米递送、2）治疗诊断纳米颗粒和3）纳米药物。内容ChemMedChem出版了以下吸引人的内容：全文和通讯评论和小评论专利评论亮点和概念书籍和多媒体评论。
Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800755
Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900040
Design of Natural‐Product‐Inspired Multitarget Ligands by Machine Learning
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900097
Development of Fibrates as Important Scaffolds in Medicinal Chemistry
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900128
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900397
H2O2‐Responsive Organosilica‐Doxorubicin Nanoparticles for Targeted Imaging and Killing of Cancer Cells Based on a Synthesized Silane‐Borate Precursor
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900142
Bivalent SMAC Mimetics for Treating Cancer by Antagonizing Inhibitor of Apoptosis Proteins
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900410
Structure−Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900544
Six Laws of Open Source Drug Discovery
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900565
Advancements in the Development of non‐BET Bromodomain Chemical Probes
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800738
Highly Porous Hybrid Metal–Organic Nanoparticles Loaded with Gemcitabine Monophosphate: a Multimodal Approach to Improve Chemo‐ and Radiotherapy
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900596
Poly[N‐(2‐hydroxypropyl)methacrylamide]‐Modified Magnetic γ‐F2O3 Nanoparticles Conjugated with Doxorubicin for Glioblastoma Treatment
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900564
Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900277
Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900349
Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900621
A Smart Nanotherapeutic Agent for in\u2005vitro and in\u2005vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900543
An Overview, Advantages and Therapeutic Potential of Nonpeptide Positive Allosteric Modulators of Glucagon‐Like Peptide‐1 Receptor
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800699
Synthesis and Cytotoxicity of Octahydroepoxyisoindole‐7‐carboxylic Acids and Norcantharidin–Amide Hybrids as Norcantharidin Analogues
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900180
A Two‐Step Multicomponent Synthetic Approach and Anti‐inflammatory Evaluation of N‐Substituted 2‐Oxopyrazines
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800634
Chemical Space Overlap with Critical Protein–Protein Interface Residues in Commercial and Specialized Small‐Molecule Libraries
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800537
Structure and energetics of ligand-fluorine interactions with galectin-3 backbone and side-chain amides - insight into solvation effects and multipolar interactions.
来源期刊：ChemMedChemDOI：10.2210/PDB6QLO/PDB
2‐Phenyloxazole‐4‐carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase\u2005B
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900261
Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900546
Identifying Lysophosphatidic Acid Acyltransferase\u2005β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800554
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900329
New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800702
Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900390
Potential Targets of Actein Identified by Systems Chemical Biology Methods
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900499
Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900508
Fragment Growing to Design Optimized Inhibitors for Human Blood Group\u2005B Galactosyltransferase (GTB)
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900296
Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3‐Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900170
Discovery and Pharmacophore Mapping of a Low‐Nanomolar Inhibitor of P. falciparum Growth
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900526
Chiral Pool Synthesis, Biological Evaluation and Molecular Docking Studies of C‐Furanosidic LpxC Inhibitors
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900068
Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900129
Roles of the Conserved Amino Acid Residues in Reduced Human Defensin\u20055: Cysteine and Arginine Are Indispensable for Its Antibacterial Action and LPS Neutralization
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900282
Ligand‐ and Structure‐Based Approaches of Escherichia coli FabI Inhibition by Triclosan Derivatives: From Chemical Similarity to Protein Dynamics Influence
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900415
Microtubule‐Targeting 7‐Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug‐Resistance Proteins
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800658
The Application of Biomaterials in the Treatment of Platinum‐Resistant Ovarian Cancer
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900450
Synthesis and Antiviral Evaluation of 3′‐Fluoro‐4′‐modified‐5′‐norcarbocyclic Nucleoside Phosphonates
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800804
Oxidative Cyclization‐Induced Activation of a Phosphoinositide 3‐Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900481
Novel BQCA‐ and TBPB‐Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900283
Targeting iNOS As a Valuable Strategy for the Therapy of Glioma
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900580
Structure‐Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases
来源期刊：ChemmedchemDOI：10.1002/cmdc.201900441
Rational Adaptation of L3MBTL1 Inhibitors to Create Small‐Molecule Cbx7 Antagonists
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900021
[18F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor‐Bearing Mice
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900297
Diamondoid Amino Acid‐Based Peptide Kinase\u2005A Inhibitor Analogues
来源期刊：ChemMedChemDOI：10.1002/cmdc.201800779
An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900303
A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900398
Divergent Synthesis and Evaluation of the in\u2005vitro Cytotoxicity Profiles of 3,4‐Ethylenedioxythiophenyl‐2‐propen‐1‐one Analogues
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900225
Discovery of Novel Biased Opioid Receptor Ligands through Structure‐Based Pharmacophore Virtual Screening and Experiment
来源期刊：ChemMedChemDOI：10.1002/cmdc.201900418
