Contemporary biomedical research is on the threshold of an era in which physiological and pathological processes can be analyzed in increasingly precise and mechanistic terms. The transformation of biology from a largely descriptive, phenomenological discipline to one in which the regulatory principles can be understood and manipulated with predictability brings a new dimension to the study of cancer and the search for effective therapeutic modalities for this disease. Cancer and Metastasis Reviews provides a forum for critical review and discussion of these challenging developments.Each issue of Cancer and Metastasis Reviews is devoted to a particular theme or topic and will contain from five to seven different contributions. In addition, an introductory preface is included from an individual who is distinguished in the field to be covered. The topics and contributors are chosen by the Editor-in-Chief after consultation with various members of the Editorial Advisory Board. Special emphasis is placed on subjects which are of relevance to the molecular and cellular biology of cancer metastasis and tumor progression, as well as to the treatment of metastatic disease. Occasional issues will be devoted to an in-depth clinical and biological analysis of a particular type of cancer.A major function of the journal is to review some of the more important and interesting recent developments in the biology and treatment of malignant disease, as well as to highlight new and promising directions, be they technological or conceptual. Contributors are encouraged to review their personal work and be speculative.
当代生物医学研究正处于一个时代的门槛，在这个时代中，生理和病理过程可以用越来越精确和机械的术语来分析。生物学从一个主要是描述性的、现象学的学科转变为一个可以理解和可预测地操纵调节原则的学科，这为癌症研究和寻找有效的治疗方法带来了新的维度。癌症和转移评论为批判性的评论和讨论这些具有挑战性的发展提供了一个论坛。每一期癌症和转移评论都致力于一个特定的主题或话题，并将包含五到七个不同的贡献。此外，还包括一个介绍性前言，从个人谁是杰出的领域所涵盖的。主题和撰稿人由主编与编辑咨询委员会各成员协商后选定。特别强调与癌症转移和肿瘤进展的分子和细胞生物学以及转移性疾病的治疗相关的主题。期刊的主要功能是回顾恶性肿瘤的生物学和治疗方面一些更重要和有趣的最新进展，以及突出新的和有前途的方向，无论是技术上的还是概念上的。鼓励投稿人回顾他们的个人作品并进行推测。
Causes, consequences, and therapy of tumors acidosis
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09792-7
The Warburg metabolism fuels tumor metastasis
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09794-5
Extracellular acidity and increased exosome release as key phenotypes of malignant tumors
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09783-8
Update on gastric cancer treatments and gene therapies
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09803-7
Cell surface–anchored serine proteases in cancer progression and metastasis
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09811-7
Exosomes, metastases, and the miracle of cancer stem cell markers
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09793-6
Acidosis and cancer: from mechanism to neutralization
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09787-4
Acidosis and proteolysis in the tumor microenvironment
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09796-3
Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09781-w
Molecular and functional imaging insights into the role of hypoxia in cancer aggression
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09788-3
The role of proteases in epithelial-to-mesenchymal cell transitions in cancer
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09808-2
Pro- and antitumor effects of mitochondrial reactive oxygen species
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09789-2
Exosomes as a storehouse of tissue remodeling proteases and mediators of cancer progression
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09813-5
KISS1 in breast cancer progression and autophagy
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09814-4
Na+,HCO3− cotransporter NBCn1 accelerates breast carcinogenesis
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09784-7
Acidosis promotes tumorigenesis by activating AKT/NF-κB signaling
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09785-6
Progress toward liquid biopsies in pediatric solid tumors
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09825-1
The plasminogen activator inhibitor-1 paradox in cancer: a mechanistic understanding
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09806-4
Beyond the biomarker role: prostate-specific antigen (PSA) in the prostate cancer microenvironment
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09815-3
Immunotherapy in pediatric acute lymphoblastic leukemia
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09834-0
Intracellular pH dynamics and charge-changing somatic mutations in cancer
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09791-8
Specifically targeting cancer proliferation and metastasis processes: the development of matriptase inhibitors
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09802-8
Functional disparities within the TIMP family in cancer: hints from molecular divergence
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09812-6
Pathological and therapeutic aspects of matrix metalloproteinases: implications in childhood leukemia
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09828-y
Differential roles of protease isoforms in the tumor microenvironment
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09816-2
MicroRNA as a prognostic biomarker for survival in childhood acute lymphoblastic leukemia: a systematic review
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09826-0
Current management of succinate dehydrogenase–deficient gastrointestinal stromal tumors
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09818-0
Aberrantly expressed microRNAs and their implications in childhood central nervous system tumors
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09820-6
Spatio-temporal modeling and live-cell imaging of proteolysis in the 4D microenvironment of breast cancer
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09810-8
It is not just the drugs that matter: the nocebo effect
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09800-w
Novel therapy for pediatric and adolescent kidney cancer
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09822-4
Compare and contrast: pediatric cancer versus adult malignancies
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09836-y
MicroRNA dysregulation interplay with childhood abdominal tumors
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09829-x
Wilms tumor, medulloblastoma, and rhabdomyosarcoma in adult patients: lessons learned from the pediatric experience
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09831-3
New attempts for central nervous infiltration of pediatric acute lymphoblastic leukemia
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09827-z
Joint-preservation surgery for pediatric osteosarcoma of the knee joint
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09835-z
Role of meprin metalloproteases in metastasis and tumor microenvironment
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09805-5
Surgical approaches in pediatric neuro-oncology
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09832-2
Preface to “Proteases in Cancer Progression and Metastasis” special issue
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09817-1
Pediatric diffuse intrinsic pontine glioma: where do we stand?
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09824-2
Minimally invasive surgery to treat embryonal tumors of childhood
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09830-4
Professor Lina M. Obeid (1955–2019)
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09837-x
Preface
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09838-w
Redirecting T cells to treat solid pediatric cancers
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09821-5
Biography—Judith Clements
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09809-1
Biographies
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09833-1
Navigating the heterogeneous landscape of pediatric Kaposi sarcoma
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09823-3
Correction to: Tumor pH and metastasis: a malignant process beyond hypoxia
来源期刊：Cancer and Metastasis ReviewsDOI：10.1007/s10555-019-09801-9
