BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease.The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements.In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.
《生物因子》是国际生物化学与分子生物学联合会的期刊，致力于快速发表健康与疾病实验生物学领域具有高度重大意义的原创研究文章和综述， "生物因子"一词指的是调节生物功能的众多化合物。生物因子包括许多由活生物体产生或修饰的分子，并存在于许多基本系统如血液、神经或免疫系统中。生物因子的非穷举列表包括神经递质、细胞因子、趋化因子、激素、凝血因子、转录因子、信号分子、受体配体等等。在生物因子这一组中，我们可以容纳几种在体内没有合成的经典分子，如维生素、微量营养素或必需微量元素。为了保持这种统一的生物化学观点， BioFactors发表了关于新物质的鉴定及其在生物物理、生物化学、细胞和人体水平上的功能说明的研究，以及揭示已知生物因子新功能的研究。该杂志鼓励提交使用生物化学、生物物理学、细胞和分子生物学和/或细胞信号途径的研究。
Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage
来源期刊：BioFactorsDOI：10.1002/biof.1513
Benefits of curcumin in brain disorders
来源期刊：BioFactorsDOI：10.1002/biof.1533
Effects of curcumin on mitochondria in neurodegenerative diseases
来源期刊：BioFactorsDOI：10.1002/biof.1566
Early detection of cervical cancer based on high‐risk HPV DNA‐based genosensors: A systematic review
来源期刊：BioFactorsDOI：10.1002/biof.1465
Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach.
来源期刊：BioFactorsDOI：10.1002/biof.1556
LncRNA DGCR5 regulates the non-small cell lung cancer cell growth, migration, and invasion through regulating miR-211-5p/EPHB6 axis.
来源期刊：BioFactorsDOI：10.1002/biof.1539
Transplantation of fecal microbiota from patients with alcoholism induces anxiety/depression behaviors and decreases brain mGluR1/PKC ε levels in mouse.
来源期刊：BioFactorsDOI：10.1002/biof.1567
miR-155-5p and miR-760 mediate radiation therapy suppressed malignancy of non-small cell lung cancer cells.
来源期刊：BioFactorsDOI：10.1002/biof.1500
Withaferin A ameliorates renal injury due to its potent effect on inflammatory signaling.
来源期刊：BioFactorsDOI：10.1002/biof.1534
The effects of statins on microglial cells to protect against neurodegenerative disorders: A mechanistic review
来源期刊：BioFactorsDOI：10.1002/biof.1597
Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses.
来源期刊：BioFactorsDOI：10.1002/biof.1583
Osteogenic potential of zingerone, a phenolic compound in mouse mesenchymal stem cells.
来源期刊：BioFactorsDOI：10.1002/biof.1515
Knockdown of LncRNA GHET1 suppresses prostate cancer cell proliferation by inhibiting HIF-1α/Notch-1 signaling pathway via KLF2.
来源期刊：BioFactorsDOI：10.1002/biof.1486
Quercetin: A promising phytochemical for the treatment of glioblastoma multiforme
来源期刊：BioFactorsDOI：10.1002/biof.1605
Paraoxonase 1 and atherosclerosis‐related diseases
来源期刊：BioFactorsDOI：10.1002/biof.1549
Functional capabilities of probiotic strains on attenuation of intestinal epithelial cell inflammatory response induced by TLR4 stimuli
来源期刊：BioFactorsDOI：10.1002/biof.1475
The impact of resveratrol on toxicity and related complications of advanced glycation end products: A systematic review
来源期刊：BioFactorsDOI：10.1002/biof.1531
The role of epigenetic changes in preeclampsia
来源期刊：BioFactorsDOI：10.1002/biof.1542
Combination of metformin and luteolin synergistically protects carbon tetrachloride-induced hepatotoxicity: Mechanism involves antioxidant, anti-inflammatory, antiapoptotic, and Nrf2/HO-1 signaling pathway.
来源期刊：BioFactorsDOI：10.1002/biof.1521
Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach
来源期刊：BioFactorsDOI：10.1002/biof.1522
Network analysis, and human and animal studies disclose the anticystitis glandularis effects of vitamin C.
来源期刊：BioFactorsDOI：10.1002/biof.1558
Alteration in serum concentrations of FGF19, FGF21, and FGF23 in patients with urothelial carcinoma
来源期刊：BioFactorsDOI：10.1002/biof.1460
Emerging roles for high‐density lipoproteins in neurodegenerative disorders
来源期刊：BioFactorsDOI：10.1002/biof.1541
Vicenin‐2 acts as a radiosensitizer of the non‐small cell lung cancer by lowering Akt expression
来源期刊：BioFactorsDOI：10.1002/biof.1472
Oxidative post‐translational modifications in histones
来源期刊：BioFactorsDOI：10.1002/biof.1532
Reactive oxygen, nitrogen, and sulfur species in human male fertility. A crossroad of cellular signaling and pathology
来源期刊：BioFactorsDOI：10.1002/biof.1535
A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre‐diabetes
来源期刊：BioFactorsDOI：10.1002/biof.1569
ROR1 associates unfavorable prognosis and promotes lymphoma growth in DLBCL by affecting PI3K/Akt/mTOR signaling pathway.
来源期刊：BioFactorsDOI：10.1002/biof.1498
Resveratrol improves left ventricular remodeling in chronic kidney disease via Sirt1-mediated regulation of FoxO1 activity and MnSOD expression.
来源期刊：BioFactorsDOI：10.1002/biof.1584
High dose vitamin D supplementation is associated with an improvement in serum markers of liver function.
来源期刊：BioFactorsDOI：10.1002/biof.1496
Effect of high fat diet on NF‐кB microRNA146a negative feedback loop in ovalbumin‐sensitized rats
来源期刊：BioFactorsDOI：10.1002/biof.1466
Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks.
来源期刊：BioFactorsDOI：10.1002/biof.1562
Mid‐region parathyroid hormone‐related protein is a genome‐wide chromatin‐binding factor that promotes growth and differentiation of HB2 epithelial cells from the human breast
来源期刊：BioFactorsDOI：10.1002/biof.1484
Novel findings of 18β-glycyrrhetinic acid on sRAGE secretion through inhibition of transient receptor potential canonical channels in high-glucose environment.
来源期刊：BioFactorsDOI：10.1002/biof.1517
microRNA-29b inhibits cell growth and promotes sensitivity to oxaliplatin in colon cancer by targeting FOLR1.
来源期刊：BioFactorsDOI：10.1002/biof.1579
Withaferin A reverses bile duct ligation-induced liver fibrosis by modulating extracellular matrix deposition: Role of LOXL2/Snail1, vimentin, and NFκB signaling.
来源期刊：BioFactorsDOI：10.1002/biof.1546
Gypenoside A protects ischemia/reperfusion injuries by suppressing miR-143-3p level via the activation of AMPK/Foxo1 pathway.
来源期刊：BioFactorsDOI：10.1002/biof.1601
Leptin decreases circulating inflammatory IL‐6 and MCP‐1 in mice
来源期刊：BioFactorsDOI：10.1002/biof.1457
Sitagliptin protects liver against aflatoxin B1-induced hepatotoxicity through upregulating Nrf2/ARE/HO-1 pathway.
来源期刊：BioFactorsDOI：10.1002/biof.1573
Modulatory effects of curcumin on the atherogenic activities of inflammatory monocytes: Evidence from in vitro and animal models of human atherosclerosis
来源期刊：BioFactorsDOI：10.1002/biof.1603
Effect of biotin supplementation on fatty acid metabolic pathways in 3T3‐L1 adipocytes
来源期刊：BioFactorsDOI：10.1002/biof.1480
Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1.
来源期刊：BioFactorsDOI：10.1002/biof.1505
Nrf2‐modulation by seleno‐hormetic agents and its potential for radiation protection
来源期刊：BioFactorsDOI：10.1002/biof.1578
Fisetin, a phytopolyphenol, targets apoptotic and necroptotic cell death in HepG2 cells.
来源期刊：BioFactorsDOI：10.1002/biof.1577
Angelica polysaccharide exhibits antitumor effect in neuroblastoma cell line SH-SY5Y by up-regulation of miR-205.
来源期刊：BioFactorsDOI：10.1002/biof.1586
A novel variant in LPL gene is associated with familial combined hyperlipidemia.
来源期刊：BioFactorsDOI：10.1002/biof.1570
Knockdown of circular RNA circZNF652 remits LPS‐induced inflammatory damage by regulating miR‐181a
来源期刊：BioFactorsDOI：10.1002/biof.1606
Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells.
来源期刊：BioFactorsDOI：10.1002/biof.1551
Lyso-diacylglyceryltrimethylhomoserine (lyso-DGTS) isolated from Nannochloropsis microalgae improves high-density lipoprotein (HDL) functions.
来源期刊：BioFactorsDOI：10.1002/biof.1580
Long noncoding RNA Mirt2 prohibits lipopolysaccharide-evoked HK-2 cell injury via modulation of microRNA-126.
来源期刊：BioFactorsDOI：10.1002/biof.1602
