Acta Neuropathologica aims to publish the best papers on pathology of neurological disease, as well as experimental studies on molecular and cellular mechanisms using in vitro and in vivo models, ideally validated by analysis of human tissues.The journal publishes Original Papers, Review Articles, Case Reports, and Scientific Correspondence (Letters).Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identiy of the subjects under study should be omitted.Reports of animal experiments must state that the "Principles of laboratory animal care" (NIH publication No. 86-23, revised 1985) were followed, as well as specific national laws (e.g. the current version of the German Law on the Protection of Animals) where applicable.The editors reserve the right to reject manuscripts that do not comply with the above-mentioned requirements. The author will be held responsible for false statements or for failure to fulfil the above-mentioned requirements.
Acta Neuropathologica旨在发表有关神经疾病病理学的最佳论文，以及使用体外和体内模型进行的分子和细胞机制的实验研究，通过对人体组织的分析得到理想的验证。该杂志发表原始论文，评论文章，病例报告，和科学通信(信件)。提交出版的手稿必须包含一份声明，大意是所有人类研究都经过了适当的伦理委员会的审查，因此是根据《赫尔辛基1964宣言》适当版本中规定的伦理标准进行的。案文中还应明确指出，所有人在纳入研究之前均已知情同意。可能披露被研究对象身份的细节应省略。动物实验报告必须说明遵循“实验动物护理原则” (美国国立卫生研究院第86-23号出版物，1985修订)，以及适用的具体国家法律(例如德国保护动物法律的当前版本)。编辑保留拒绝不符合上述要求的手稿的权利。提交人将对虚假陈述或未能满足上述要求负责。
Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02020-0
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02026-8
FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01998-x
H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01975-4
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01995-0
Selective vulnerability in α-synucleinopathies
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02010-2
SORL1 genetic variants and Alzheimer disease risk: a literature review and meta-analysis of sequencing data
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01991-4
Precise detection of low-level somatic mutation in resected epilepsy brain tissue
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02052-6
Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid angiopathy and Alzheimer’s disease
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01967-4
Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01990-5
Oral and intravenous transmission of α-synuclein fibrils to mice
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02037-5
Neurotoxicity of pesticides
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02033-9
Mitochondrial defect in muscle precedes neuromuscular junction degeneration and motor neuron death in CHCHD10S59L/+ mouse
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01988-z
Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02019-7
An update on the central nervous system manifestations of neurofibromatosis type 1
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02002-2
The neuropathology of fatal encephalomyelitis in human Borna virus infection
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02047-3
Splicing repression is a major function of TDP-43 in motor neurons
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02042-8
Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02082-0
Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02050-8
YAP1-fusions in pediatric NF2-wildtype meningioma
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02095-9
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02066-0
Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01976-3
Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01979-0
Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01974-5
Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02018-8
Severe bornavirus-encephalitis presenting as Guillain–Barré-syndrome
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02005-z
An update on the central nervous system manifestations of Li–Fraumeni syndrome
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02055-3
Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02101-0
Neuroinflammation, the thread connecting neurological disease
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02009-9
Alpha-synuclein: prion or prion-like?
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02057-1
Production of poly(GA) in C9ORF72 patient motor neurons derived from induced pluripotent stem cells
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02083-z
Evidence of corticofugal tau spreading in patients with frontotemporal dementia
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02075-z
Translational control in brain pathologies: biological significance and therapeutic opportunities
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01971-8
A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02081-1
Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02091-z
Loss of UGP2 in brain leads to a severe epileptic encephalopathy, emphasizing that bi-allelic isoform-specific start-loss mutations of essential genes can cause genetic diseases
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02109-6
Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02012-0
Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-01981-6
Desmoplastic myxoid tumor, SMARCB1-mutant: clinical, histopathological and molecular characterization of a pineal region tumor encountered in adolescents and adults
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02094-w
Human subiculo-fornico-mamillary system in Alzheimer’s disease: Tau seeding by the pillar of the fornix
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02108-7
Subcortical TDP-43 pathology patterns validate cortical FTLD-TDP subtypes and demonstrate unique aspects of C9orf72 mutation cases
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02070-4
Lewy-related pathology exhibits two anatomically and genetically distinct progression patterns: a population-based study of Finns aged 85+
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02071-3
Overlapping genetic architecture between Parkinson disease and melanoma
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02110-z
Posterior fossa pilocytic astrocytomas with oligodendroglial features show frequent FGFR1 activation via fusion or mutation
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02097-7
NF1 patient missense variants predict a role for ATM in modifying neurofibroma initiation
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02086-w
Tectal glioma harbors high rates of KRAS G12R and concomitant KRAS and BRAF alterations
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02112-x
Neuroglial stem cell-derived inflammatory pseudotumor (n-SCIPT): clinicopathologic characterization of a novel lesion of the lumbosacral spinal cord and nerve roots following intrathecal allogeneic stem cell intervention
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02089-7
Neurotoxicology: an update on epidemiology, mechanisms, and pathology
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02051-7
Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02092-y
Molecular progression of SHH-activated medulloblastomas
来源期刊：Acta NeuropathologicaDOI：10.1007/s00401-019-02022-y
