The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.
《国际临床药理学和治疗学杂志》每月出版一次，并出版包含原始材料的手稿，重点关注以下主题：临床试验、药物流行病学-药物警戒、药效学、药物处置和药代动力学、质量保证、药物遗传学、生物技术药物（如细胞因子和重组抗生素）。不良反应的病例报告也值得关注。
Effect of triple therapy in patients with asthma-COPD overlap
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203382
A PK/PD study comparing twice-daily to once-daily dosing regimens of ertugliflozin in healthy subjects
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203343
Population pharmacokinetics and dosage optimization of tacrolimus in pediatric patients with nephrotic syndrome\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203355
Comparison of long-term efficacy and renal safety of febuxostat and allopurinol in patients with chronic kidney diseases\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203466
Generics in transplantation medicine: Randomized comparison of innovator and substitution products containing mycophenolate mofetil
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203487
Multiple severe vertebral fractures during the 3-month period following a missed dose of denosumab in a postmenopausal woman with osteoporosis previously treated with alendronate\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203361
Pharmacokinetic/pharmacodynamic analysis of meropenem, by Monte Carlo simulation, in both plasma and cerebrospinal fluid in patients with cerebral hemorrhage after external ventricular drainage\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203606
A meta-analysis of the influence of UGT1A6 genetic polymorphisms on valproic acid pharmacokinetics\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203357
Regulation of serum uric acid with canagliflozin monotherapy in type 2 diabetes: A potential link between uric acid and pancreatic β-cell function\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203513
Insulin depot absorption modeling and pharmacokinetic simulation with insulin glargine 300 U/mL
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203269
Comparative efficacy and safety of biosimilar rituximab and originator rituximab in combination with methotrexate in patients with active rheumatoid arthritis: A Bayesian network meta-analysis\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203360
Population pharmacokinetics of tofacitinib in patients with psoriatic arthritis
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203516
Association between depression and risk of triggering ventricular arrhythmias: A meta-analysis.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203311
A phase I, randomized, double-blinded, single-dose study evaluating the pharmacokinetic equivalence of the biosimilar IBI305 and bevacizumab in healthy male subjects\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203349
Comparison of the effects of peramivir and oseltamivir on the rise in platelet count in patients with or without proven influenza\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203366
Effect of pharmacokinetic model misspecification on antibiotic probability of target attainment predicted by Monte Carlo simulation\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203446
Oral anticoagulant prescribing in elderly patients above and below age 80 with atrial fibrillation\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203502
Association between malignancy and methotrexate and biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203604
Population pharmacokinetics of cyclosporine A in Chinese patients with nephrotic syndrome in individualized drug administration\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203335
Physiologically based pharmacokinetic modeling to predict exposures in healthy Japanese subjects with different CYP2C19 phenotypes: Esomeprazole case study\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203488
Topiroxostat influences circulating lipid concentrations in hyperuricemic patients\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203478
Investigation of bioequivalence, safety, and tolerability of a fixed-dose combination of nifedipine GITS and candesartan compared with the corresponding loose-dose combination under fed conditions\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203200
Appropriate therapeutic drug monitoring of antibiotics contributed to lower nephrotoxicity\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203545
Nadir lymphocytopenia as a risk factor of bloodstream infection during molecular targeting pharmacotherapy in multiple myeloma.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203455
The role of general practitioners and psychiatrists in issuing initiation and follow-up prescriptions for selective serotonin (norepinephrine) reuptake inhibitors in Germany\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203410
Association between chronic kidney disease and synergistic, potentially nephrotoxic medication use in elderly hospitalized patients: A single-center cross-sectional study\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203429
The association between clopidogrel and 2-oxo-clopidogrel plasma levels and the long-term clinical outcome after acute myocardial infarction\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203190
Clinical effectiveness of switching between DPP-4 inhibitors in patients with type 2 diabetes mellitus\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203409
Relationship between the blood concentrations of tacrolimus and voriconazole in hematopoietic stem cell transplant recipients\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203539
Use of azilsartan medoxomil in the primary-care setting in Germany: A real-world evidence study
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203359
Comparison of N-glycans expressed in tumor tissues with those expressed in adjacent non-tumor tissues of colorectal cancer patients\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203332
Evaluation of folic acid supplementation by concomitant administration of ethinyl estradiol + levonorgestrel in healthy female subjects\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203293
Adherence to guidelines for antiulcer drug prescription in patients receiving low-dose aspirin therapy in Japan.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203370
Pharmacokinetics and bioequivalence of two oral formulations of canagliflozin after single-dose administration in healthy Chinese subjects\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203437
Bioequivalence of two tacrolimus 1-mg formulations under fasting conditions in healthy subjects: A randomized, two-period crossover trial
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203534
Pharmacokinetics and exploratory efficacy biomarkers of bococizumab, an anti-PCSK9 monoclonal antibody, in hypercholesterolemic Japanese subjects
来源期刊：International Journal of Clinical Pharmacology and TherapeuticsDOI：10.5414/CP203418
Pharmacokinetics and safety of transdermal and oral granisetron in healthy Chinese subjects: An open-label, randomized, crossover study\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203327
Inappropriate drug use in the elderly outpatient population in a West-African metropolitan community\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203421
Is anti-tuberculosis drug-induced hepatotoxicity due to a change in pharmacokinetics caused by alterations in antioxidant gene expression and polymorphisms in the NFE2L2 gene?\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP202599
Pharmacokinetics and bioequivalence of two fenofibrate choline formulations in healthy subjects under fed and fasted condition\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203353
Pharmacodynamics of 250 mg and 500 mg oral furosemide in peritoneal dialysis\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203594
Provider factors influencing prescriptions of recommended antihypertensive medications among patients with diabetes and hypertension\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203403
Comparison of the gastric acid inhibition function among lansoprazole, pantoprazole, and their respective stereoisomers in healthy Chinese subjects\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203514
Comparison of CYP3A5*3 genotyping assays for personalizing immunosuppressive therapy in heart transplant patients\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203381
Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203535
Clinical efficacy of low-dose rituximab on hematological abnormalities in patients with connective tissue disease\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203453
Population pharmacokinetic study of delayed methotrexate excretion in children with acute lymphoblastic leukemia\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203423
Pharmacokinetics of trazodone sustained-release tablets in healthy subjects: Three open-label, randomized crossover studies\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203482
Real-world prescribing and switching patterns of non-calcium containing phosphate binders in dialysis patients in South Korea\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203609
Pharmacokinetic comparisons of two different varenicline formulations in humans: Varenicline tartrate versus varenicline oxalate\u2029.
来源期刊：International journal of clinical pharmacology and therapeuticsDOI：10.5414/CP203574
