The aim of Aging Cell is to publish the highest quality, innovative research addressing fundamental issues in the biology of aging. For publication in Aging Cell, the work must provide a major new contribution to the understanding of aging and be of general interest to the community. Aging Cell seeks to cover all areas of geroscience, highlighting research that uncovers mechanistic aspects of the aging process, as well as the links between aging and age-related disease.
衰老细胞的目的是发表最高质量的,创新的研究,解决基本问题的生物老化。要在《老化细胞》杂志上发表,作品必须对理解老化做出重大的新贡献,并引起社区的普遍兴趣。衰老细胞试图涵盖老年科学的所有领域,突出研究,揭示了衰老过程的机械方面,以及衰老和年龄相关疾病之间的联系。
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
来源期刊:Aging CellDOI:10.1111/acel.12876
Measuring biological aging in humans: A quest
来源期刊:Aging CellDOI:10.1111/acel.13080
Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells
来源期刊:Aging CellDOI:10.1111/acel.12841
Astrocyte senescence: Evidence and significance
来源期刊:Aging CellDOI:10.1111/acel.12937
Sirt1–hypoxia‐inducible factor‐1α interaction is a key mediator of tubulointerstitial damage in the aged kidney
来源期刊:Aging CellDOI:10.1111/acel.12904
Born this way: Hippocampal neurogenesis across the lifespan
来源期刊:Aging CellDOI:10.1111/acel.13007
Extranuclear DNA accumulates in aged cells and contributes to senescence and inflammation
来源期刊:Aging CellDOI:10.1111/acel.12901
Acarbose improves health and lifespan in aging HET3 mice
来源期刊:Aging CellDOI:10.1111/acel.12898
An early‐senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro‐inflammatory program
来源期刊:Aging CellDOI:10.1111/acel.12933
Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite
来源期刊:Aging CellDOI:10.1111/acel.12936
Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation
来源期刊:Aging CellDOI:10.1111/acel.12845
Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease
来源期刊:Aging CellDOI:10.1111/acel.12928
Drosophila insulin‐like peptide dilp1 increases lifespan and glucagon‐like Akh expression epistatic to dilp2
来源期刊:Aging CellDOI:10.1111/acel.12863
IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype
来源期刊:Aging CellDOI:10.1111/acel.12946
Are skin senescence and immunosenescence linked within individuals?
来源期刊:Aging CellDOI:10.1111/acel.12956
Chondrocyte‐like nested cells in the aged intervertebral disc are late‐stage nucleus pulposus cells
来源期刊:Aging CellDOI:10.1111/acel.13006
The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
来源期刊:Aging CellDOI:10.1111/acel.12913
Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging
来源期刊:Aging CellDOI:10.1111/acel.12915
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice
来源期刊:Aging CellDOI:10.1111/acel.12856
Tau‐induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila
来源期刊:Aging CellDOI:10.1111/acel.12847
Dietary alpha‐ketoglutarate promotes beige adipogenesis and prevents obesity in middle‐aged mice
来源期刊:Aging CellDOI:10.1111/acel.13059
HIF1α‐mediated AIMP3 suppression delays stem cell aging via the induction of autophagy
来源期刊:Aging CellDOI:10.1111/acel.12909
Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity
来源期刊:Aging CellDOI:10.1111/acel.13002
Activation of MT2 receptor ameliorates dendritic abnormalities in Alzheimer’s disease via C/EBPα/miR‐125b pathway
来源期刊:Aging CellDOI:10.1111/acel.12902
Functional microbiome deficits associated with ageing: Chronological age threshold
来源期刊:Aging CellDOI:10.1111/acel.13063
Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization
来源期刊:Aging CellDOI:10.1111/acel.12932
LncRNAs regulating stemness in aging
来源期刊:Aging CellDOI:10.1111/acel.12870
Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection
来源期刊:Aging CellDOI:10.1111/acel.13018
Hormone replacement therapy attenuates hearing loss: Mechanisms involving estrogen and the IGF‐1 pathway
来源期刊:Aging CellDOI:10.1111/acel.12939
Endothelial toll‐like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a
来源期刊:Aging CellDOI:10.1111/acel.12914
Senescent cells: A new Achilles’ heel to exploit for cancer medicine?
来源期刊:Aging CellDOI:10.1111/acel.12875
Cell‐type‐specific role of lamin‐B1 in thymus development and its inflammation‐driven reduction in thymus aging
来源期刊:Aging CellDOI:10.1111/acel.12952
Improved mitochondrial stress response in long‐lived Snell dwarf mice
来源期刊:Aging CellDOI:10.1111/acel.13030
Global metabolic profiling to model biological processes of aging in twins
来源期刊:Aging CellDOI:10.1111/acel.13073
Age‐dependent DNA methylation patterns on the Y chromosome in elderly males
来源期刊:Aging CellDOI:10.1111/acel.12907
Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation
来源期刊:Aging CellDOI:10.1111/acel.13037
α‐Synuclein toxicity in yeast and human cells is caused by cell cycle re‐entry and autophagy degradation of ribonucleotide reductase 1
来源期刊:Aging CellDOI:10.1111/acel.12922
MPK‐1/ERK is required for the full activity of resveratrol in extended lifespan and reproduction
来源期刊:Aging CellDOI:10.1111/acel.12867
Longevity‐related molecular pathways are subject to midlife “switch” in humans
来源期刊:Aging CellDOI:10.1111/acel.12970
Carbon monoxide attenuates amyloidogenesis via down‐regulation of NF‐κB‐mediated BACE1 gene expression
来源期刊:Aging CellDOI:10.1111/acel.12864
Rag1 immunodeficiency‐induced early aging and senescence in zebrafish are dependent on chronic inflammation and oxidative stress
来源期刊:Aging CellDOI:10.1111/acel.13020
Changes in presynaptic calcium signalling accompany age‐related deficits in hippocampal LTP and cognitive impairment
来源期刊:Aging CellDOI:10.1111/acel.13008
Base excision repair but not DNA double‐strand break repair is impaired in aged human adipose‐derived stem cells
来源期刊:Aging CellDOI:10.1111/acel.13062
Nontuberculous mycobacterium M. avium infection predisposes aged mice to cardiac abnormalities and inflammation
来源期刊:Aging CellDOI:10.1111/acel.12926
Aging differentially modulates the Wnt pro‐survival signalling pathways in vascular smooth muscle cells
来源期刊:Aging CellDOI:10.1111/acel.12844
PGC‐1a integrates a metabolism and growth network linked to caloric restriction
来源期刊:Aging CellDOI:10.1111/acel.12999
Compromised steady‐state germinal center activity with age in nonhuman primates
来源期刊:Aging CellDOI:10.1111/acel.13087
RanGAP‐mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain
来源期刊:Aging CellDOI:10.1111/acel.12854
Analysis of somatic mutations identifies signs of selection during in vitro aging of primary dermal fibroblasts
来源期刊:Aging CellDOI:10.1111/acel.13010
A genome‐wide screen identifies genes that suppress the accumulation of spontaneous mutations in young and aged yeast cells
来源期刊:Aging CellDOI:10.1111/acel.13084