As the average human life expectancy has increased, so too has the impact of ageing and age-related disease on our society. Ageing research is now the focus of thousands of laboratories that include leaders in the areas of genetics, molecular and cellular biology, biochemistry, and behaviour. Ageing Research Reviews (ARR) covers the trends in this field. It is designed to fill a large void, namely, a source for critical reviews and viewpoints on emerging findings on mechanisms of ageing and age-related disease. Rapid advances in understanding of mechanisms that control cellular proliferation, differentiation and survival are leading to new insight into the regulation of ageing. From telomerase to stem cells to energy and oxyradical metabolism, this is an exciting new era in the multidisciplinary field of ageing research. The cellular and molecular underpinnings of manipulations that extend lifespan, such as caloric restriction, are being identified and novel approaches for preventing age-related diseases are being developed. ARR publishes articles on focussed topics selected from the broad field of ageing research, with an emphasis on cellular and molecular mechanisms of the aging process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Applications of basic ageing research to lifespan extension and disease prevention are also covered in this journal.
随着人类平均预期寿命的增加，老龄化和与年龄有关的疾病对我们社会的影响也在增加。衰老研究现在是数千个实验室的重点，其中包括遗传学、分子和细胞生物学、生物化学和行为学领域的领导者。老龄化研究评论（ARR）涵盖了这一领域的趋势。它的目的是填补一个巨大的空白，即对老龄化和与年龄有关的疾病的机制的新发现进行批判性审查和提出观点。对控制细胞增殖、分化和存活的机制的理解的快速进展导致对衰老调节的新认识。从端粒酶到干细胞再到能量和氧自由基代谢，这是衰老研究多学科领域令人兴奋的新时代。延长寿命的操作（如热量限制）的细胞和分子基础正在被确定，预防年龄相关疾病的新方法正在开发中。ARR发表的文章集中于从广泛的老龄化研究领域中选择的主题，重点是老龄化过程的细胞和分子机制以及与年龄相关的疾病，如癌症、心血管疾病、糖尿病和神经退行性疾病。这本杂志还介绍了基础老龄化研究在延长寿命和预防疾病方面的应用。
Transitions between frailty states among community-dwelling older people: A systematic review and meta-analysis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.010
Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100944
Neuroinflammation in mild cognitive impairment and Alzheimer’s disease: A meta-analysis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.002
Inflammation and cerebral small vessel disease: A systematic review
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100916
Targeting normal and cancer senescent cells as a strategy of senotherapy
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100941
The influence of fasting and energy restricting diets on IGF-1 levels in humans: A systematic review and meta-analysis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100910
Age-related diseases as vicious cycles
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2018.11.002
The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.012
Is Alzheimer’s disease an inflammasomopathy?
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100966
MicroRNAs and mild cognitive impairment: A systematic review
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2018.11.005
Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.02.005
Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100980
ALTERED IMMUNE SYSTEM IN FRAILTY: GENETICS AND DIET MAY INFLUENCE INFLAMMATION
来源期刊：Ageing research reviewsDOI：10.1016/j.arr.2019.100935
Mitochondria in the signaling pathways that control longevity and health span
来源期刊：Ageing research reviewsDOI：10.1016/j.arr.2019.100940
Olfactory dysfunction in the pathophysiological continuum of dementia
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100956
Do anti-amyloid-β drugs affect neuropsychiatric status in Alzheimer’s disease patients?
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100948
Frailty as a predictor of adverse outcomes in hospitalized older adults: A systematic review and meta-analysis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100960
Effect of soluble cleavage products of important receptors/ligands on efferocytosis: Their role in inflammatory, autoimmune and cardiovascular disease
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.007
Exploring the relationship between physical activity, beta-amyloid and tau: A narrative review
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.003
Caveolin-1 in skin aging – From innocent bystander to major contributor
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100959
Does senescence promote fitness in Caenorhabditis elegans by causing death?
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.008
Intestinal epithelial barrier functions in ageing
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100938
Emerging roles of long non-coding RNAs in the pathogenesis of Alzheimer’s disease
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.001
The functional changes of the circadian system organization in aging
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.04.006
Developmental origins of type 2 diabetes: Focus on epigenetics
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100957
Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer’s disease. Exploring the crossroad of eternal youth and premature aging
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100915
Age-related hearing loss and tinnitus, dementia risk, and auditory amplification outcomes
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100963
The peculiar aging of human liver: A geroscience perspective within transplant context
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.02.002
Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100909
Reversibility of irreversible aging
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2018.11.008
Where are we now in relation to determining the prevalence of ageism in this era of escalating population ageing?
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.03.001
The role of transposable elements activity in aging and their possible involvement in laminopathic diseases
来源期刊：Ageing research reviewsDOI：10.1016/j.arr.2019.100995
MRI-based evaluation of structural degeneration in the ageing brain: Pathophysiology and assessment
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2018.11.004
Amyloid cross-seeding raises new dimensions to understanding of amyloidogenesis mechanism
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100937
Revamping the Evolutionary Theories of Aging
来源期刊：Ageing research reviewsDOI：10.1016/j.arr.2019.100947
A systematic literature review and meta-analysis of real-world interventions for cognitive ageing in healthy older adults
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.006
The effect of ageing on the resolution of inflammation
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.101000
Frailty for predicting all-cause mortality in elderly acute coronary syndrome patients: A meta-analysis
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.03.003
The optimal treatment for improving cognitive function in elder people with mild cognitive impairment incorporating Bayesian network meta-analysis and systematic review
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.009
Effects of sustained cognitive activity on white matter microstructure and cognitive outcomes in healthy middle-aged adults: A systematic review
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.02.004
Anti-ageing gene therapy: Not so far away?
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100977
Unravelling protein aggregation as an ageing related process or a neuropathological response
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.02.001
Physiological functions of CKIP-1: From molecular mechanisms to therapy implications
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.05.002
Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.04.004
The Y682ENPTY687 motif of APP: Progress and insights toward a targeted therapy for Alzheimer’s disease patients
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.04.003
Ghrelin in Alzheimer’s disease: Pathologic roles and therapeutic implications
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100945
The role of DNA methylation and hydroxymethylation in immunosenescence
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.01.011
Development of new treatments for Alzheimer’s disease based on the modulation of translocator protein (TSPO)
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100943
Non-pharmacological therapeutic strategy options for patients with dementia based on cognitive function—A Bayesian network meta-analysis of randomized controlled trials
来源期刊：Ageing Research ReviewsDOI：10.1016/j.arr.2019.100965
Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance.
来源期刊：Ageing research reviewsDOI：10.1016/j.arr.2019.100964
