Advancing Life Sciences R&D: SLAS Discovery reports how scientists develop and utilize novel technologies and/or approaches to provide and characterize chemical and biological tools to understand and treat human disease.SLAS Discovery is a peer-reviewed journal that publishes scientific reports that enable and improve target validation, evaluate current drug discovery technologies, provide novel research tools, and incorporate research approaches that enhance depth of knowledge and drug discovery success.SLAS Discovery emphasizes scientific and technical advances in target identification/validation (including chemical probes, RNA silencing, gene editing technologies); biomarker discovery; assay development; virtual, medium- or high-throughput screening (biochemical and biological, biophysical, phenotypic, toxicological, ADME); lead generation/optimization; chemical biology; and informatics (data analysis, image analysis, statistics, bio- and chemo-informatics). Review articles on target biology, new paradigms in drug discovery and advances in drug discovery technologies.SLAS Discovery is of particular interest to those involved in analytical chemistry, applied microbiology, automation, biochemistry, bioengineering, biomedical optics, biotechnology, bioinformatics, cell biology, DNA science and technology, genetics, information technology, medicinal chemistry, molecular biology, natural products chemistry, organic chemistry, pharmacology, spectroscopy, and toxicology.SLAS Discovery is a member of the Committee on Publication Ethics (COPE) and was published previously (1996-2016) as the Journal of Biomolecular Screening (JBS).
推进生命科学研发：SLAS Discovery报告科学家如何开发和利用新的技术和/或方法来提供和表征化学和生物学工具，以了解和治疗人类疾病。 SLAS Discovery是一个同行评审的杂志，发布科学报告，实现和改进靶验证，评估当前的药物发现技术，提供新的研究工具，SLAS Discovery强调在靶标鉴定/验证方面的科学和技术进步（包括化学探针、 RNA沉默、基因编辑技术）;生物标志物发现;分析开发;虚拟、中等或高通量筛选（生化和生物学、生物物理学、表型、毒理学、 ADME ）;潜在客户开发/优化;化学生物学;和信息学（数据分析、图像分析、统计学、生物和化学信息学）。综述关于靶生物学、药物发现新范例和药物发现技术进展的文章。 SLAS Discovery对那些涉及分析化学、应用微生物学、自动化、生物化学、生物工程、生物医学光学、生物技术、生物信息学、细胞生物学、 DNA科学和技术、遗传学、信息技术、药物化学、分子生物学、天然产物化学、有机化学、药理学、光谱学和毒理学。 SLAS Discovery是出版伦理委员会（COPE ）的成员，之前（1996 - 2016 ）曾作为《生物分子筛选杂志》 （JBS ）出版。
Transfer Learning with Deep Convolutional Neural Networks for Classifying Cellular Morphological Changes
来源期刊：Slas DiscoveryDOI：10.1177/2472555218818756
OCTN: A Small Transporter Subfamily with Great Relevance to Human Pathophysiology, Drug Discovery, and Diagnostics
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218812821
Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218812429
NanoBiT Complementation to Monitor Agonist-Induced Adenosine A1 Receptor Internalization
来源期刊：Slas DiscoveryDOI：10.1177/2472555219880475
A Therapeutic Role for the F1FO-ATP Synthase
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219860448
Influence of Matrigel on Single- and Multiple-Spheroid Cultures in Breast Cancer Research
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219834698
Targeting RNA with Small Molecules: Identification of Selective, RNA-Binding Small Molecules Occupying Drug-Like Chemical Space
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219885373
Identification and Characterization of Inhibitors of a Neutral Amino Acid Transporter, SLC6A19, Using Two Functional Cell-Based Assays
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218794627
Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218818065
Morphology-Based Analysis of Myoblasts for Prediction of Myotube Formation
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218793374
Integrated Multiparametric High-Content Profiling of Endothelial Cells
来源期刊：Slas DiscoveryDOI：10.1177/2472555218820848
Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219859837
A Phenotypic Screening Assay Identifies Modulators of Diamond Blackfan Anemia
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218823531
High-Content Imaging for Large-Scale Detection of Low-Affinity Extracellular Protein Interactions
来源期刊：Slas DiscoveryDOI：10.1177/2472555219879053
A Perspective on Extreme Open Science: Companies Sharing Compounds without Restriction
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219838210
Application of New Cellular and Microphysiological Systems to Drug Metabolism Optimization and Their Positioning Respective to In Silico Tools
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219831407
CRISPR: A Screener’s Guide
来源期刊：Slas DiscoveryDOI：10.1177/2472555219883621
Implementation of a High-Throughput Pilot Screen in Peptide Hydrogel-Based Three-Dimensional Cell Cultures
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219844570
Structures and Interactions of Transmembrane Targets in Native Nanodiscs
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219857691
EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology
来源期刊：Slas DiscoveryDOI：10.1177/2472555218816276
Evaluation of Machine Learning Classifiers to Predict Compound Mechanism of Action When Transferred across Distinct Cell Lines
来源期刊：Slas DiscoveryDOI：10.1177/2472555218820805
A High-Throughput BRET Cellular Target Engagement Assay Links Biochemical to Cellular Activity for Bruton’s Tyrosine Kinase
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219884881
Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219896278
Drug Target Engagement Using Coupled Cellular Thermal Shift Assay—Acoustic Reverse-Phase Protein Array
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219897256
Image-Based Marker-Free Screening of GABAA Agonists, Antagonists, and Modulators
来源期刊：Slas DiscoveryDOI：10.1177/2472555219887142
Addition of Optimized Bovine Serum Albumin Level in a High-Throughput Caco-2 Assay Enabled Accurate Permeability Assessment for Lipophilic Compounds
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219848483
Development of a High-Throughput Cytometric Screen to Identify Anti-Wolbachia Compounds: The Power of Public–Private Partnership
来源期刊：Slas DiscoveryDOI：10.1177/2472555219838341
Medium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219884033
Chemical Derivatization Enables MALDI-TOF-Based High-Throughput Screening for Microbial Trimethylamine (TMA)-Lyase Inhibitors
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219838216
Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218796410
xCELLanalyzer: A Framework for the Analysis of Cellular Impedance Measurements for Mode of Action Discovery
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218819459
Current Progress on Equilibrative Nucleoside Transporter Function and Inhibitor Design
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219870123
Lysyl-tRNA Synthetase from Pseudomonas aeruginosa: Characterization and Identification of Inhibitory Compounds
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219873095
High-Throughput Implementation of the NanoBRET Target Engagement Intracellular Kinase Assay to Reveal Differential Compound Engagement by SIK2/3 Isoforms
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219893277
The Scripps Molecular Screening Center and Translational Research Institute
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218820809
Novel Cell-Based Assay for Identification of LRRK2 Inhibitors Using Its Aberrant Regulation of a Pluripotency Gene
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219864086
A Sensitive and Selective Immunoassay for the Quantitation of Serum Latent Myostatin after In Vivo Administration of SRK-015, a Selective Inhibitor of Myostatin Activation
来源期刊：Slas DiscoveryDOI：10.1177/2472555219860779
High-Density Cell Arrays for Genome-Scale Phenotypic Screening
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218818757
Development of a Bioluminescent High-Throughput Screening Assay for Nicotinamide Mononucleotide Adenylyltransferase (NMNAT)
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219879644
Live Cell Membranome cDNA Screen: A Novel Homogenous Live Cell Binding Assay to Study Membrane Protein-Ligand Interaction
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219873069
A Cell-Based Renilla Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219860771
Response to the Article “Enzyme–Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality”
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219872211
Identification of Novel Compounds Enhancing SR-BI mRNA Stability through High-Throughput Screening
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219894543
Identification of Novel Mast Cell Activators Using Cell-Based High-Throughput Screening
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219834699
Rebuttal to Response to the Article “Enzyme–Inhibitor Interactions and a Simple, Rapid Method for Determining Inhibition Modality”
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219875106
Development of a Bacterial Macroarray for the Rapid Screening of Targeted Antibody-Secreted Hybridomas
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218804990
DNA Switch: Toehold-Mediated DNA Isothermal Amplification for Dengue Serotyping
来源期刊：SLAS DiscoveryDOI：10.1177/2472555218791743
Generation of a Monoclonal Antibody against D-Dimer Using HTS-Based LiCA
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219878407
Reviewer List
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219831670
Novel 2-Benzoyl-6-(2,3-Dimethoxybenzylidene)-Cyclohexenol Confers Selectivity toward Human MLH1 Defective Cancer Cells through Synthetic Lethality
来源期刊：SLAS DiscoveryDOI：10.1177/2472555219831405
