Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products. Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged. Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.
毒理学和应用药理学发表与动物或人类有关的化学品、药物或化学定义的天然产物的作用的原始科学研究。定期发表的文章阐述了生理学、药理学、生物化学、细胞或分子对毒理学/病理学损伤的理解的机制方法，以及用于描述这些反应的方法。安全性科学文章采用尖端科学，阐述了药物和化学品安全性的杰出的最先进的临床前和人体转化表征。高度重要的监管安全性科学文章也将在此类别中考虑。鼓励发表有关替代实验动物使用的论文。对TAAP读者有广泛兴趣的高影响力研究的短文报道，这些文章将从快速出版中受益。这些文章包含的图表总数不应超过四个。作者应在其附信中说明将其手稿作为短文考虑的理由。
Polychlorinated biphenyl exposures differentially regulate hepatic metabolism and pancreatic function: Implications for nonalcoholic steatohepatitis and diabetes
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.10.011
MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1‐Nrf2 pathway
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.03.001
Altered bile acid composition and disposition in a mouse model of non-alcoholic steatohepatitis.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114664
Degradation of MCL-1 by bufalin reverses acquired resistance to osimertinib in EGFR-mutant lung cancer.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114662
Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114629
Heme oxygenase-1 attenuates low-dose of deoxynivalenol-induced liver inflammation potentially associating with microbiota.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.04.020
Developmental exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) selectively decreases brain dopamine levels in northern leopard frogs.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114623
Lung injury, oxidative stress and fibrosis in mice following exposure to nitrogen mustard.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114798
Parental exposure to 2,2′,4,4′5 ‐ pentain polybrominated diphenyl ethers (BDE‐99) causes thyroid disruption and developmental toxicity in zebrafish
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.04.008
Kaempferol‐3‐O‐glucorhamnoside inhibits inflammatory responses via MAPK and NF‐&kgr;B pathways in vitro and in vivo
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.12.008
The interaction of zinc and the blood‐brain barrier under physiological and ischemic conditions
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.12.018
L‐Carnosine protects against Oxaliplatin‐induced peripheral neuropathy in colorectal cancer patients: A perspective on targeting Nrf‐2 and NF‐&kgr;B pathways
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.12.015
Clozapine‐induced reduction of l‐carnitine reabsorption via inhibition/down‐regulation of renal carnitine/organic cation transporter 2 contributes to liver lipid metabolic disorder in mice
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.11.007
Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.12.006
Glucocorticoid programming mechanism for hypercholesterolemia in prenatal ethanol-exposed adult offspring rats.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.05.002
Multigenerational consequences of early‐life cannabinoid exposure in zebrafish
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.12.021
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.04.007
Toxicokinetics and bioavailability of bisphenol AF following oral administration in rodents: A dose, species, and sex comparison
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.04.015
Progress in data interoperability to support computational toxicology and chemical safety evaluation.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114707
The comparative effects of high dose atorvastatin and proprotein convertase subtilisin/kexin type 9 inhibitor on the mitochondria of oxidative muscle fibers in obese-insulin resistant female rats.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114741
Low concentrations of perfluorooctane sulfonate repress osteogenic and enhance adipogenic differentiation of human mesenchymal stem cells
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.02.001
Polycyclic aromatic hydrocarbons exposure and hematotoxicity in occupational population: A two-year follow-up study.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114622
Differential response to lead toxicity in rat primary microglia and astrocytes
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.11.010
Structure-activity study of acute neurobehavioral effects of cyclohexane, benzene, m-xylene, and toluene in rats.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.05.016
Modeling of antipsychotics-induced metabolic alterations in mice: An experimental approach precluding psychosis as a predisposing factor.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114643
A multiplexed UPLC‐MS/MS assay for the simultaneous measurement of urinary safety biomarkers of drug‐induced kidney injury and phospholipidosis
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.01.012
Urban air pollution induces redox imbalance and epithelium hyperplasia in mice cornea.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114770
Genotoxic and immunotoxic effects of the organophosphate metabolite diethyldithiophosphate (DEDTP) in Vivo
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.01.023
Early life inhalation exposure to mine tailings dust affects lung development
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.01.009
Gant61 ameliorates CCl4-induced liver fibrosis by inhibition of Hedgehog signaling activity.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114853
Characterization of the modes of action and dose‐response relationship for thiocyanate on the thyroid hormone levels in rats using a computational approach
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.01.007
Acetyl‐macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti‐cancer effects with the Chk1/2 inhibitor AZD7762
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.01.005
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114686
Small molecule PIKfyve inhibitors as cancer therapeutics: Translational promises and limitations.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114771
Cytotoxicity and oxidative stress induced by nickel and titanium ions from dental alloys on cells of gastrointestinal tract.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114784
N-arylpiperazine-containing compound (C2): An enhancer of sunitinib in the treatment of pancreatic cancer, involving D1DR activation.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114789
Cardiovascular variability and &bgr;‐ARs gene expression at two stages of doxorubicin – Induced cardiomyopathy
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2018.10.015
NF-κB-regulation of miR-155, via SOCS1/STAT3, is involved in the PM2.5-accelerated cell cycle and proliferation of human bronchial epithelial cells.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114616
Evidence for the involvement of opioid and cannabinoid systems in the peripheral antinociception mediated by resveratrol
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.02.004
PFKFB3 promotes endotoxemia‐induced myocardial dysfunction through inflammatory signaling and apoptotic induction
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.02.007
Adoptive transfer of DMSO-induced regulatory T cells exhibits a similar preventive effect compared to an in vivo DMSO treatment for chemical-induced experimental encapsulating peritoneal sclerosis in mice.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114641
The compartmentalised nature of the mechanisms governing superoxide formation and scavenging in cells exposed to arsenite.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114766
Untargeted LC‐MS‐based metabonomics revealed that aristolochic acid I induces testicular toxicity by inhibiting amino acids metabolism, glucose metabolism, &bgr;‐oxidation of fatty acids and the TCA cycle in male mice
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.04.014
Dipeptidyl peptidase-4 inhibitor sitagliptin induces vasorelaxation via the activation of Kv channels and PKA.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114799
Suppression of macrophages- Induced inflammation via targeting RAS and PAR-4 signaling in breast cancer cell lines.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114773
The antineoplastic agent anacardic 6-pentadecyl salicylic acid produces immunomodulation in vivo via the activation of MAPKs.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.05.017
An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114783
Identification of differentially expressed genes and networks related to hepatic lipid dysfunction.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114757
Coordinated cytochrome P450 expression in mouse liver and intestine under different dietary conditions during liver regeneration after partial hepatectomy
来源期刊：Toxicology and Applied PharmacologyDOI：10.1016/j.taap.2019.03.010
Structure-activity relationship study: Mechanism of cyto-genotoxicity of Nitropyrazole-derived high energy density materials family.
来源期刊：Toxicology and applied pharmacologyDOI：10.1016/j.taap.2019.114712
