Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.
《生命科学》是一本国际性期刊，发表的文章强调治疗的分子、细胞和功能基础。该杂志强调对与人类疾病各方面相关的机制的理解和对患者的翻译。所有的文章都经过严格的审查。该杂志倾向于发表完整长度的论文，其中现代科学技术被用来解释分子，细胞和生理机制。仅报告观察结果的文章很少被接受。必须遵守赫尔辛基宣言或NIH指南中关于实验室动物护理和使用的建议。文章应该写在一个水平，以方便读者谁是非专家在文章的主题本身，但谁是有兴趣的研究。《华尔街日报》欢迎对生命科学研究者广泛感兴趣的主题进行评论。我们特别鼓励提交包含高质量插图的简短、重点突出的评论，并要求使用机械摘要图。
Cancer stem cell (CSC) resistance drivers.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116781
Proton pump inhibitors therapy and risk of bone diseases: An update meta‐analysis
来源期刊：Life SciencesDOI：10.1016/j.lfs.2018.12.058
Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116660
Eugenol ameliorates insulin resistance, oxidative stress and inflammation in high fat‐diet/streptozotocin‐induced diabetic rat
来源期刊：Life SciencesDOI：10.1016/j.lfs.2018.11.034
LncRNA SNHG1 modulates p38 MAPK pathway through Nedd4 and thus inhibits osteogenic differentiation of bone marrow mesenchymal stem cells.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.05.002
Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116607
Oleuropein suppresses oxidative, inflammatory, and apoptotic responses following glycerol-induced acute kidney injury in rats.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116634
Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS).
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.04.046
Protective role of melatonin on retinal ganglionar cell: In vitro an in vivo evidences
来源期刊：Life SciencesDOI：10.1016/j.lfs.2018.12.053
Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116966
Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.05.041
Roles of taurine in cognitive function of physiology, pathologies and toxication.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116584
Protective effect of dexmedetomidine against diabetic hyperglycemia-exacerbated cerebral ischemia/reperfusion injury: An in vivo and in vitro study.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116553
Neuroprotective effects of novel nanosystems simultaneously loaded with vinpocetine and piracetam after intranasal administration
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.04.014
Ginsenoside Rg1 protects human retinal pigment epithelial ARPE‐19 cells from toxicity of high glucose by up‐regulation of miR‐26a
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.02.021
miR-19 family: A promising biomarker and therapeutic target in heart, vessels and neurons.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116651
Atorvastatin inhibits pro-inflammatory actions of aldosterone in vascular smooth muscle cells by reducing oxidative stress
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.01.043
Substance P accelerates wound repair by promoting neovascularization and preventing inflammation in an ischemia mouse model
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.04.015
Oscillating flow promotes inflammation through the TLR2-TAK1-IKK2 signalling pathway in human umbilical vein endothelial cell (HUVECs).
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.03.033
The Protective Effects of Angiotensin-Converting Enzyme Inhibitor against Cecal Ligation and Puncture-Induced Sepsis via Oxidative Stress and Inflammation.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.117051
BCLAF1 promotes cell proliferation, invasion and drug-resistance though targeting lncRNA NEAT1 in hepatocellular carcinoma.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.117177
Molecular mechanisms by which SGLT2 inhibitors can induce insulin sensitivity in diabetic milieu: A mechanistic review.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.117090
Increased expression of miR-155 correlates with abnormal allograft status in solid organ transplant patients and rat kidney transplantation model.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.04.043
Klotho restrain RIG-1/NF-κB signaling activation and monocyte inflammatory factor release under uremic condition.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116570
Multidrug resistance-associated protein 4 in pharmacology: Overview of its contribution to pharmacokinetics, pharmacodynamics and pharmacogenetics.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.06.015
The PERK/Nrf2 pathway mediates endoplasmic reticulum stress-induced injury by upregulating endoplasmic reticulophagy in H9c2 cardiomyoblasts.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116944
The role of Wnt/β-catenin pathway in the protection process by dexmedetomidine against cerebral ischemia/reperfusion injury in rats.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116921
Clinical importance of FASN in relation to HIF-1α and SREBP-1c in gastric adenocarcinoma.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.03.056
Electroacupuncture pretreatment attenuates brain injury in a mouse model of cardiac arrest and cardiopulmonary resuscitation via the AKT/eNOS pathway.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116821
Is there an association between asthma and periodontal disease among adults? Systematic review and meta‐analysis
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.03.005
High glucose regulates ERp29 in hepatocellular carcinoma by LncRNA MEG3-miRNA 483-3p pathway.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116602
Physical training improves exercise tolerance, cardiac function and promotes changes in neurotrophins levels in chagasic mice.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116629
miR-145-5p promotes trophoblast cell growth and invasion by targeting FLT1.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.117008
SOCS3 ablation enhances DC‐derived Th17 immune response against Candida albicans by activating IL‐6/STAT3 in vitro
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.03.009
Linalyl acetate prevents three related factors of vascular damage in COPD-like and hypertensive rats.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116608
Artemisinin attenuates the development of atherosclerotic lesions by the regulation of vascular smooth muscle cell phenotype switching.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116943
Erythromycin relaxes BALB/c mouse airway smooth muscle
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.02.009
Targeted depletion of monocyte/macrophage suppresses aortic dissection with the spatial regulation of MMP-9 in the aorta.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116927
Unravelling the wound healing ability and mode of action of pyridine carboxamide oxime using Caenorhabditis elegans as potential prescreen wound model.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116859
Corticotropin‐releasing factor suppresses glioma progression by upregulation of long non‐coding RNA‐p21
来源期刊：Life SciencesDOI：10.1016/j.lfs.2018.07.003
Effect of endoplasmic reticulum stress-mediated excessive autophagy on apoptosis and formation of kidney stones.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.117232
Inhibition of Siah2 ubiquitin ligase ameliorates monocrotaline-induced pulmonary arterial remodeling through inactivation of YAP.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.117159
Species and sex differences in the blood clearance and immunogenicity of PEGylated uricase: A comparative 26-week toxicity study in rats and monkeys.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116892
Endogenous TRPC channels mediate Ca2+ signals and trigeminal synaptic plasticity induced by mGluR5a.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.116567
Maternal hyperuricemia superimposed on maternal hypertension aggravates the risk of small-for-gestational-age fetus.
来源期刊：Life sciencesDOI：10.1016/j.lfs.2019.04.033
Maternal metabolic syndrome and selenium: Endocrine energy balance during early programming.
来源期刊：Life SciencesDOI：10.1016/J.LFS.2019.116689
Even weak vasoconstriction from rilmenidine can be unmasked in vivo by opening the baroreflex feedback loop
来源期刊：Life SciencesDOI：10.1016/j.lfs.2019.01.009
