The Journal of Molecular Medicine publishes original research articles and review articles that range from basic findings in mechanisms of disease pathogenesis to therapy. The focus includes all human diseases, including but not limited to:Aging, angiogenesis, autoimmune diseases as well as other inflammatory diseases, cancer, cardiovascular diseases, development and differentiation, endocrinology, gastrointestinal diseases and hepatology, genetics and epigenetics, hematology, hypoxia research, immunology, infectious diseases, metabolic disorders, neuroscience of diseases, -omics based disease research, regenerative medicine, and stem cell research.Studies solely based on cell lines will not be considered. Studies that are based on model organisms will be considered as long as they are directly relevant to human disease.
《分子医学杂志》发表原创研究文章和综述文章,内容涵盖从疾病发病机制到治疗的基本发现。重点包括所有人类疾病,包括但不限于:衰老、血管生成、自身免疫性疾病以及其他炎症性疾病、癌症、心血管疾病、发育和分化、内分泌学、胃肠疾病和肝病学、遗传学和表观遗传学、血液学、缺氧研究、免疫学、感染性疾病、代谢紊乱、疾病神经科学、基于组学的疾病研究、再生医学和干细胞研究。只要与人类疾病直接相关,将考虑基于模式生物的研究。
Exploring the roles of MSCs in infections: focus on bacterial diseases
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01752-6
Activation of NF-κB in B cell receptor signaling through Bruton’s tyrosine kinase-dependent phosphorylation of IκB-α
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01777-x
Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01781-1
Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01756-2
Anti-oxidative effects of superoxide dismutase 3 on inflammatory diseases
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01845-2
The vital role of ATP citrate lyase in chronic diseases
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01863-0
Klotho recovery by genistein via promoter histone acetylation and DNA demethylation mitigates renal fibrosis in mice
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01759-z
MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01751-7
Benefits of a factorial design focusing on inclusion of female and male animals in one experiment
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01774-0
Insights in the immunobiology of glioblastoma
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01835-4
Co-delivery of GOLPH3 siRNA and gefitinib by cationic lipid-PLGA nanoparticles improves EGFR-targeted therapy for glioma
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01843-4
Exosomes from patients with Parkinson’s disease are pathological in mice
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01810-z
Mitochondrial complex I deficiency and cardiovascular diseases: current evidence and future directions
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01771-3
Serpin B1 defect and increased apoptosis of neutrophils in Cohen syndrome neutropenia
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01754-4
Pathological cardiac hypertrophy: the synergy of adenylyl cyclases inhibition in cardiac and immune cells during chronic catecholamine stress
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01790-0
Progranulin alleviates podocyte injury via regulating CAMKK/AMPK-mediated autophagy under diabetic conditions
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01828-3
Connecting sex differences, estrogen signaling, and microRNAs in cardiac fibrosis
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01833-6
Radiation-induced glucocorticoid receptor promotes CD44+ prostate cancer stem cell growth through activation of SGK1-Wnt/β-catenin signaling
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01807-8
Macrophage derived TNFα promotes hepatic reprogramming to Warburg-like metabolism
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01786-w
Regulation of osteoblast behaviors via cross-talk between Hippo/YAP and MAPK signaling pathway under fluoride exposure
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01785-x
Identification of novel scaffolds targeting Mycobacterium tuberculosis
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01840-7
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01769-x
S100A4 promotes inflammation but suppresses lipid accumulation via the STAT3 pathway in chronic ethanol-induced fatty liver
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01808-7
Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01796-8
Heterogeneous intracellular TRAIL-receptor distribution predicts poor outcome in breast cancer patients
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01805-w
Novel lysophosphatidic acid receptor 6 antagonists inhibit hepatocellular carcinoma growth through affecting mitochondrial function
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01862-1
Random gene sets in predicting survival of patients with hepatocellular carcinoma
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01764-2
Are glutamate transporters neuroprotective or neurodegenerative during cerebral ischemia?
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01745-5
Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01782-0
c-Jun N-terminal Kinase 1 ablation protects against metabolic-induced hippocampal cognitive impairments
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01856-z
MicroRNA-145 targets Smad1 in endometrial stromal cells and regulates decidualization in rat
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01744-6
Mechanism and biomarkers in aortitis––a review
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01838-1
Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01791-z
Role of adiponectin in the metabolism of skeletal muscles in collagen VI–related myopathies
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01766-0
Autophagy plays a critical role in Klotho gene deficiency-induced arterial stiffening and hypertension
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01841-6
The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01836-3
NOD1 inhibits proliferation and enhances response to chemotherapy via suppressing SRC-MAPK pathway in hepatocellular carcinoma
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01868-9
Preclinical studies of a death receptor 5 fusion protein that ameliorates acute liver failure
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01813-w
Systemic thrombin inhibition ameliorates seizures in a mouse model of pilocarpine-induced status epilepticus
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01837-2
A rapid, safe, and quantitative in vitro assay for measurement of uracil-DNA glycosylase activity
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01788-8
A combination of two novel VARS2 variants causes a mitochondrial disorder associated with failure to thrive and pulmonary hypertension
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01834-5
Correction to: STIM1 deficiency is linked to Alzheimer’s disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01816-7
Comment on “Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis”
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01773-1
Response to Yang et. al
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01775-z
Tumor cells endowed with professional antigen-presenting cell functions prime PBLs to generate antitumor CTLs
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01797-7
Adipose-derived stromal cell secretome disrupts autophagy in glioblastoma
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01829-2
Correction to: Elevated expression of CST1 promotes breast cancer progression and predicts a poor prognosis
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01806-9
Bone marrow chimeras—a vital tool in basic and translational research
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01783-z
Selective protection of murine cerebral Gi/o-proteins from inactivation by parenterally injected pertussis toxin
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01854-1
Correction to: Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma
来源期刊:Journal of Molecular MedicineDOI:10.1007/s00109-019-01748-2