Broadly speaking, the Journal of Pharmacokinetics and Pharmacodynamics covers the area of pharmacometrics. The journal is devoted to illustrating the importance of pharmacokinetics, pharmacodynamics, and pharmacometrics in drug development, clinical care, and the understanding of drug action. The journal publishes on a variety of topics related to pharmacometrics, including, but not limited to, clinical, experimental, and theoretical papers examining the kinetics of drug disposition and effects of drug action in humans, animals, in vitro, or in silico; modeling and simulation methodology, including optimal design; precision medicine; systems pharmacology; and mathematical pharmacology (including computational biology, bioengineering, and biophysics related to pharmacology, pharmacokinetics, orpharmacodynamics). Clinical papers that include population pharmacokinetic-pharmacodynamic relationships are welcome. The journal actively invites and promotes up-and-coming areas of pharmacometric research, such as real-world evidence, quality of life analyses, and artificial intelligence. The Journal of Pharmacokinetics and Pharmacodynamics is an official journal of the International Society of Pharmacometrics.
Pharmacokinetics与Pharmacodynamics期刊从广义上讲，《药代动力学和药效学杂志》涵盖了药物计量学领域。该杂志致力于阐明药物动力学、药效学和药物计量学在药物开发、临床护理和药物作用理解中的重要性。该杂志发表了与药物计量学相关的各种主题，包括但不限于临床、实验和理论论文，研究药物处置动力学和药物在人体、动物、体外或计算机模拟中的作用;建模和模拟方法，包括优化设计;精准医疗;系统药理学;数学药理学（包括计算生物学、生物工程学和与药理学、药代动力学或药效学相关的生物物理学）。欢迎发表包含群体药代动力学-药效学关系的临床论文。该杂志积极邀请和促进药物计量学研究的新兴领域，如现实世界证据、生活质量分析和人工智能。《药代动力学和药效学杂志》是国际药物计量学学会的官方杂志。
Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09626-7
Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09627-6
Challenge model of TNFα turnover at varying LPS and drug provocations
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09622-x
Development and evaluation of a generic population pharmacokinetic model for standard half-life factor VIII for use in dose individualization
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09634-7
Estimating parameters of nonlinear dynamic systems in pharmacology using chaos synchronization and grid search
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09629-4
Operating characteristics of stepwise covariate selection in pharmacometric modeling
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09635-6
A translational platform PBPK model for antibody disposition in the brain
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09641-8
Orphan drug development: the increasing role of clinical pharmacology
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09646-3
Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09642-7
Population pharmacokinetic reanalysis of a Diazepam PBPK model: a comparison of Stan and GNU MCSim
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09630-x
Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09637-4
Pitfalls of using numerical predictive checks for population physiologically-based pharmacokinetic model evaluation
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09636-5
Cabozantinib exposure–response analyses of efficacy and safety in patients with advanced hepatocellular carcinoma
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09659-y
Development of visual predictive checks accounting for multimodal parameter distributions in mixture models
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09632-9
Concentration–response modeling of ECG data from early-phase clinical studies to assess QT prolongation risk of contezolid (MRX-I), an oxazolidinone antibacterial agent
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09650-7
Mathematical modeling of the glucagon challenge test
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09655-2
Population pharmacokinetics and pharmacodynamics of piperacillin in critically ill patients during the early phase of sepsis
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09633-8
Tumor necrosis factor-mediated disposition of infliximab in ulcerative colitis patients
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09652-5
Bioequivalence for highly variable drugs: regulatory agreements, disagreements, and harmonization
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09623-w
Reproducible pharmacokinetics
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09621-y
A physiologically-motivated model of cystic fibrosis liquid and solute transport dynamics across primary human nasal epithelia
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09649-0
Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09666-z
Correction to: Routine clinical care data for population pharmacokinetic modeling: the case for Fanhdi/Alphanate in hemophilia A patients
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09647-2
Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09640-9
Journal editor’s final report
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09665-0
Automated proper lumping for simplification of linear physiologically based pharmacokinetic systems
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09644-5
Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09653-4
Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09638-3
FDA’s Office of Orphan Products Development: providing incentives to promote the development of products for rare diseases
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09645-4
Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09657-0
Population pharmacokinetic analysis of danvatirsen supporting flat dosing switch
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09619-6
Bayesian approach to investigate a two-state mixed model of COPD exacerbations
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09643-6
Editorial to the themed issue on application of pharmacometrics to the development of drugs for rare diseases
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09656-1
Panos Macheras: a pioneering scientist in pharmaceutical science
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09628-5
Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09663-2
Structural identifiability and sensitivity
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09624-9
Computational framework for predictive PBPK-PD-Tox simulations of opioids and antidotes
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09648-1
A quantitative systems pharmacology model of colonic motility with applications in drug development
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09651-6
Preface to Special Issue for Panos Macheras
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09631-w
Cardiac risk assessment based on early Phase I data and PK-QTc analysis is concordant with the outcome of thorough QTc trials: an assessment based on eleven drug candidates
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09662-3
Impact of Phase 1 study design on estimation of QT interval prolongation risk using exposure–response analysis
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09661-4
Correction to: Bayesian approach to investigate a two-state mixed model of COPD exacerbations
来源期刊：Journal of Pharmacokinetics and PharmacodynamicsDOI：10.1007/s10928-019-09664-1
