The mission of Toxicological Sciences, the official journal of the Society of Toxicology, is to publish a broad spectrum of impactful research in the field of toxicology.The primary focus of Toxicological Sciences is on original research articles. The journal also provides expert insight via contemporary and systematic reviews, as well as forum articles and editorial content that addresses important topics in the field.The scope of Toxicological Sciences is focused on a broad spectrum of impactful toxicological research that will advance the multidisciplinary field of toxicology ranging from basic research to model development and application, and decision making. Submissions will include diverse technologies and approaches including, but not limited to: bioinformatics and computational biology, biochemistry, exposure science, histopathology, mass spectrometry, molecular biology, population-based sciences, tissue and cell-based systems, and whole-animal studies. Integrative approaches that combine realistic exposure scenarios with impactful analyses that move the field forward are encouraged.
《毒理学使命》是美国毒理学学会的官方期刊，其宗旨是发表毒理学领域的广泛而有影响力的研究。《毒理学科学》的主要重点是原创性研究文章。《毒理学科学》杂志还通过当代和系统综述、论坛文章和社论内容提供专家见解，讨论该领域的重要主题。《毒理学科学》的范围集中于广泛的影响毒理学研究，这些研究将推动毒理学多学科领域的发展，从基础研究到模型开发和应用，以及决策制定。提交材料将包括各种技术和方法，包括但不限于：生物信息学和计算生物学、生物化学、暴露科学、组织病理学、质谱分析、分子生物学、基于群体的科学、基于组织和细胞的系统以及全动物研究。鼓励采用综合方法，将现实的暴露情景与推动该领域向前发展的有影响力的分析相结合。
Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy309
Comparative Analysis of Zebrafish and Planarian Model Systems for Developmental Neurotoxicity Screens Using an 87-Compound Library
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy180
Automated Morphological Feature Assessment for Zebrafish Embryo Developmental Toxicity Screens
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy250
Multi-Behavioral Endpoint Testing of an 87-Chemical Compound Library in Freshwater Planarians
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy145
Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy242
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy253
Dichloroacetate Ameliorates Cardiac Dysfunction Caused by Ischemic Insults Through AMPK Signal Pathway—Not Only Shifts Metabolism
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy272
Chemical Activation of the Constitutive Androstane Receptor Leads to Activation of Oxidant-Induced Nrf2
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy231
Identifying Attributes That Influence In Vitro-to-In Vivo Concordance by Comparing In Vitro Tox21 Bioactivity Versus In Vivo DrugMatrix Transcriptomic Responses Across 130 Chemicals
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy220
Transient Receptor Potential Ion Channels Mediate Adherens Junctions Dysfunction in a Toluene Diisocyanate-Induced Murine Asthma Model
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy285
Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy238
Prediction of Acute Oral Systemic Toxicity Using a Multifingerprint Similarity Approach
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy255
miR-149 Negative Regulation of mafA Is Involved in the Arsenite-Induced Dysfunction of Insulin Synthesis and Secretion in Pancreatic Beta Cells
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy150
Inhalation of ZnO Nanoparticles: Splice Junction Expression and Alternative Splicing in Mice
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy288
Repeatability and Reproducibility of the RTgill-W1 Cell Line Assay for Predicting Fish Acute Toxicity
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz057
Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy264
Targeting Smox Is Neuroprotective and Ameliorates Brain Inflammation in Cerebral Ischemia/Reperfusion Rats
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy300
Deciphering Adverse Outcome Pathway Network Linked to Bisphenol F Using Text Mining and Systems Toxicology Approaches
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz214
Dose Effects of Ammonium Perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP Mice
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz015
Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy245
Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy239
A Performance Evaluation of Liver and Skeletal Muscle-Specific miRNAs in Rat Plasma to Detect Drug-Induced Injury
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy282
Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz097
Nicotine Promotes Human Papillomavirus (HPV)-Immortalized Cervical Epithelial Cells (H8) Proliferation by Activating RPS27a-Mdm2-P53 Pathway In Vitro
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy246
Association Between Meconium Acetaminophen and Childhood Neurocognitive Development in GESTE, a Canadian Cohort Study
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy222
Effects of Organophosphate Ester Flame Retardants on Endochondral Ossification in Ex Vivo Murine Limb Bud Cultures
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy301
Sex-Dependent Effects of 2,2′,3,5′,6-Pentachlorobiphenyl on Dendritic Arborization of Primary Mouse Neurons
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy277
A Novel Open Access Web Portal for Integrating Mechanistic and Toxicogenomic Study Results
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz101
Associations Between Immune Phenotype and Inflammation in Murine Models of Irritant Contact Dermatitis
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy289
Bromate-induced Changes in p21 DNA Methylation and Histone Acetylation in Renal Cells
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz016
Prenatal Exposure to Bisphenol A Analogues on Female Reproductive Functions in Mice
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz014
Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz070
Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy228
Refining In Vitro Toxicity Models: Comparing Baseline Characteristics of Lung Cell Types
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz001
Recovery From a Myocardial Infarction Is Impaired in Male C57bl/6\u2009N Mice Acutely Exposed to the Bisphenols and Phthalates That Escape From Medical Devices Used in Cardiac Surgery
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy276
Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy244
Effects of Acute Deltamethrin Exposure in Adult and Developing Sprague Dawley Rats on Acoustic Startle Response in Relation to Deltamethrin Brain and Plasma Concentrations
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy275
Physiologically Based Kinetic Modeling-Facilitated Reverse Dosimetry to Predict In Vivo Red Blood Cell Acetylcholinesterase Inhibition Following Exposure to Chlorpyrifos in the Caucasian and Chinese Population
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz134
Arsenic May Act as a Pro-Metastatic Carcinogen Through Promoting Tumor Cell-Induced Platelet Aggregation
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy247
Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy233
Allyl Sulfide Counteracts 1-Bromopropane-Induced Neurotoxicity by Inhibiting Neuroinflammation and Oxidative Stress
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy240
Sequence Variations in pxr (nr1i2) From Zebrafish (Danio rerio) Strains Affect Nuclear Receptor Function
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy269
Oxygen and Arsenite Synergize Phosphine Toxicity by Distinct Mechanisms
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy248
Exposure to 1,2-Dichloropropane Upregulates the Expression of Activation-Induced Cytidine Deaminase (AID) in Human Cholangiocytes Co-Cultured With Macrophages
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy280
The Critical Role of X Chromosome-Linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-Phenanthroline Complex in Normal and Cancer Liver Cells
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy307
A CRISPR/Cas9 Whole-Genome Screen Identifies Genes Required for Aryl Hydrocarbon Receptor-Dependent Induction of Functional CYP1A1
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz111
All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate Toxicity
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfy283
Benzophenone-3 Passes Through the Blood-Brain Barrier, Increases the Level of Extracellular Glutamate, and Induces Apoptotic Processes in the Hippocampus and Frontal Cortex of Rats
来源期刊：Toxicological SciencesDOI：10.1093/TOXSCI/KFZ160
Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz007
Corrigendum to “Dose-Related Severity Sequence, and Risk-Based Integration, of Chemically Induced Health Effects”
来源期刊：Toxicological SciencesDOI：10.1093/toxsci/kfz105
