Nature Medicine publishes research that addresses the needs and goals of contemporary medicine. Original research ranges from new concepts in human biology and disease pathogenesis to robust preclinical bases for new therapeutic modalities and drug development to all phases of clinical work, as well as innovative technologies aimed at improving human health.Current areas of interest also include, but are not limited to:-Gene and cell therapies-Clinical genomics-Regenerative medicine-High-definition medicine-Effects of the environment in human health-Artificial intelligence in health care-Smart wearable devices-Early disease diagnosis-Microbiome-AgingNature Medicine also publishes Reviews, Perspectives and other content commissioned from leading scientists in their fields to provide expert and contextualized views of the latest research driving the progress of medicine. The News section is editorially independent and provides topical and timely reporting of upcoming trends affecting medicine, researchers and the general audience.
《自然医学》发表了针对当代医学需求和目标的研究。原创性研究范围从人类生物学和疾病发病机制的新概念到新治疗模式和药物开发的强大临床前基础，再到临床工作的各个阶段，以及旨在改善人类健康的创新技术。目前感兴趣的领域还包括但不限于：-基因和细胞疗法-临床基因组学-再生医学-高清晰度医学-环境对人类健康的影响-医疗保健中的人工智能-智能可穿戴设备-早期疾病诊断-微生物组-老龄化自然医学还出版评论、观点和其他内容，委托各自领域的领先科学家提供推动医学进步的最新研究的专家和背景化观点。新闻部分是编辑独立的，并提供专题和及时的报告即将到来的趋势影响医学，研究人员和普通观众。
Clinical-grade computational pathology using weakly supervised deep learning on whole slide images
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0508-1
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers
来源期刊：Nature medicineDOI：10.1038/s41591-019-0367-9
Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10
来源期刊：Nature MedicineDOI：10.1038/s41591-018-0327-9
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0422-6
Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0458-7
Combined BRAF and MEK inhibition with PD-1 blockade immunotherapy in BRAF-mutant melanoma
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0476-5
Clinical lessons learned from the first leg of the CAR T cell journey
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0564-6
Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0474-7
Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0400-z
Methionine is a metabolic dependency of tumor-initiating cells
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0423-5
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0559-3
Small-molecule targeting of brachyury transcription factor addiction in chordoma
来源期刊：Nature medicineDOI：10.1038/s41591-018-0312-3
Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0403-9
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
来源期刊：Nature medicineDOI：10.1038/s41591-019-0393-7
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0694-x
Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0567-3
Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0550-z
Developmental origins and emerging therapeutic opportunities for childhood cancer
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0383-9
Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination
来源期刊：Nature medicineDOI：10.1038/s41591-019-0650-9
Genetic predisposition, modifiable risk factor profile and long-term dementia risk in the general population
来源期刊：Nature medicineDOI：10.1038/s41591-019-0547-7
Autism risk in offspring can be assessed through quantification of male sperm mosaicism
来源期刊：Nature medicineDOI：10.1038/s41591-019-0711-0
Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease
来源期刊：Nature medicineDOI：10.1038/s41591-019-0627-8
Activating mutations in CSF-1R and additional receptor tyrosine kinases in histiocytic neoplasms
来源期刊：Nature medicineDOI：10.1038/s41591-019-0653-6
Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0635-8
Benefit Corporation: a path to affordable gene therapies?
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0676-z
Time to revisit oligodendrocytes in multiple sclerosis
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0388-4
Publisher Correction: Non-invasive prenatal sequencing for multiple Mendelian monogenic disorders using circulating cell-free fetal DNA
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0391-9
Toward a broader response to cardiometabolic disease
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0642-9
Divergent effects of lipids on stroke
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0413-7
Antisense therapies pose a regulatory conundrum
来源期刊：Nature MedicineDOI：10.1038/D41591-019-00014-9
High-accuracy liquid biopsies
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0690-1
Reply to ‘Simpson’s paradox in proof-of-concept studies’
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0625-x
First CRISPR editing trial results assuage safety concerns.
来源期刊：Nature medicineDOI：10.1038/d41591-019-00019-4
Regulating microbiome manipulation
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0451-1
Unexpected clues emerge about why diets fail
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0632-y
Expanded non-invasive prenatal diagnostics
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0386-6
Author Correction: Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0572-6
Author Correction: Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0698-6
Detecting opioid overdoses with smartphones
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0362-1
Author Correction: Reporting guidelines for clinical trials evaluating artificial intelligence interventions are needed
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0662-5
Finding diversity in the microbiome
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0494-3
Evidence mounts for a role for immune cells in the brain
来源期刊：Nature MedicineDOI：10.1038/D41591-019-00007-8
Prevention with a polypill
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0658-1
Gene editing fixes cystic fibrosis gene in mice before birth.
来源期刊：Nature medicineDOI：10.1038/D41591-019-00012-X
The processed food trap
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0489-0
Spreading the search
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0384-8
Nosocomial transmission of antibiotic resistance
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0589-x
Publisher Correction: Homeward bound
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0571-7
Turning up the heat on neglected diseases
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0514-3
Finding the edge of the seat
来源期刊：Nature MedicineDOI：10.1038/s41591-019-0557-5
